1. Tumor-infiltrating lymphocytes predict cutaneous melanoma survival
- Author
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Nicoletta Russo, A. Caggiati, Paola Michelozzi, Giorgio Annessi, Thomas J. Mannooranparampil, Cristina Fortes, Alba Zappalà, Simona Mastroeni, Claudia Marino, and Francesca Passarelli
- Subjects
Adult ,Male ,Oncology ,Cancer Research ,medicine.medical_specialty ,Skin Neoplasms ,Dermatology ,Lower risk ,Cohort Studies ,Breslow Thickness ,Young Adult ,Lymphocytes, Tumor-Infiltrating ,Internal medicine ,medicine ,Humans ,Melanoma ,Survival rate ,Aged ,Proportional Hazards Models ,Aged, 80 and over ,Sentinel Lymph Node Biopsy ,Tumor-infiltrating lymphocytes ,business.industry ,Proportional hazards model ,Hazard ratio ,Middle Aged ,Prognosis ,medicine.disease ,Survival Rate ,Lymphatic Metastasis ,Multivariate Analysis ,Cutaneous melanoma ,Female ,Lymph Nodes ,business - Abstract
Understanding differences in survival across distinct subgroups of melanoma patients may help with the choice of types of therapy. Tumor-infiltrating lymphocytes (TILs) are considered a manifestation of the host immune response to tumor, but the role of TILs in melanoma mortality is controversial. The aim of this study was to investigate independent prognostic factors for melanoma mortality. We carried out a 10-year cohort study on 4133 melanoma patients from the same geographic area (Lazio) with primary cutaneous melanoma diagnosed between January 1998 and December 2008. The probability of survival was estimated using Kaplan-Meier methods and prognostic factors were evaluated by multivariate analysis (Cox proportional hazards model). The 10-year survival rate for melanoma decreased with increasing Breslow thickness (Pfor trend
- Published
- 2015
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