1. Global REACH 2018
- Author
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Rómulo Figueroa-Mujíca, David B. MacLeod, Benjamin S. Stacey, Travis D. Gibbons, Gustavo Vizcardo-Galindo, Francisco C. Villafuerte, Daniela Bermudez, Michael M. Tymko, Damian M. Bailey, Philip N. Ainslie, Chris Gasho, Connor A. Howe, Ryan L. Hoiland, Joshua C. Tremblay, Kyra E. Pyke, and Geoff B. Coombs
- Subjects
Male ,Brachial Artery ,Endothelium, Vascular/physiopathology ,Polycythemia/blood/etiology/physiopathology ,Blood viscosity ,Hyperviscosity ,Blood volume ,Vasodilation ,030204 cardiovascular system & hematology ,Hemoglobins ,0302 clinical medicine ,Risk Factors ,blood flow ,purl.org/pe-repo/ocde/ford#3.02.04 [https] ,Brachial artery ,pathophysiology ,Vasodilation/physiology ,Altitude ,clinical trial ,Blood Viscosity ,vasodilatation ,Doppler ultrasonography ,risk factor ,hemodilution ,Cardiology ,vascular endothelium ,Adult ,medicine.medical_specialty ,diagnostic imaging ,Blood Viscosity/physiology ,Polycythemia ,03 medical and health sciences ,blood ,Internal medicine ,medicine.artery ,Internal Medicine ,medicine ,Shear stress ,Humans ,human ,Regional Blood Flow/physiology ,hypoxia ,business.industry ,Hemoglobins/metabolism ,Ultrasonography, Doppler ,Blood flow ,hemoglobin ,multicenter study ,Regional Blood Flow ,Brachial Artery/diagnostic imaging/physiopathology ,physiology ,Endothelium, Vascular ,Hemoglobin ,business ,metabolism ,030217 neurology & neurosurgery - Abstract
Excessive erythrocytosis (EE; hemoglobin concentration [Hb] ≥21 g/dL in adult males) is associated with increased cardiovascular risk in highlander Andeans. We sought to quantify shear stress and assess endothelial function via flow-mediated dilation (FMD) in male Andeans with and without EE. We hypothesized that FMD would be impaired in Andeans with EE after accounting for shear stress and that FMD would improve after isovolemic hemodilution. Brachial artery shear stress and FMD were assessed in 23 male Andeans without EE (age: 40±15 years [mean±SD]; HbP P =0.013) in Andeans with EE compared to those without. FMD was inversely correlated with blood viscosity ( r 2 =0.303; Pr 2 =0.230; P =0.001). Isovolemic hemodilution decreased blood viscosity by 30±10% and Hb by 14±5% (both P P =0.022). Hyperviscosity, high Hb, or both, actively contribute to acutely reversible impairments in FMD in EE, suggesting that this plays a pathogenic role in the increased cardiovascular risk.
- Published
- 2019
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