1. Pharmacokinetics of Sucralose and Acesulfame-Potassium in Breast Milk Following Ingestion of Diet Soda
- Author
-
David A. Fields, Kristina I. Rother, Peter Walter, Allison C. Sylvetsky, and H. Martin Garraffo
- Subjects
Adult ,0301 basic medicine ,Non-Nutritive Sweeteners ,Sucrose ,Sucralose ,Thiazines ,Acesulfame potassium ,Carbonated Beverages ,Breast milk ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,Pharmacokinetics ,Animals ,Humans ,Medicine ,Ingestion ,Obesity ,Food science ,Meal ,030109 nutrition & dietetics ,Milk, Human ,business.industry ,digestive, oral, and skin physiology ,Gastroenterology ,food and beverages ,Chronic ingestion ,medicine.disease ,Diet ,Milk ,030104 developmental biology ,chemistry ,Area Under Curve ,Pediatrics, Perinatology and Child Health ,Potassium ,Female ,business - Abstract
Objective: The aim of this study was to determine sucralose and acesulfame-potassium (ace-K) pharmacokinetics in breast milk following maternal ingestion of a diet soda. Methods: Thirty-four exclusively breast-feeding women (14 normal-weight, 20 obese) consumed 12 ounces of Diet Rite Cola, sweetened with 68-mg sucralose and 41-mg ace-K, before a standardized breakfast meal. Habitual non-nutritional sweeteners intake was assessed via a diet questionnaire. Breast milk was collected from the same breast before beverage ingestion and hourly for 6 hours. Results: Owing to one mother having extremely high concentrations, peak sucralose and acesulfame-potassium concentrations following ingestion of diet soda ranged from 4.0 to 7387.9 ng/mL (median peak 8.1 ng/mL) and 299.0 to 4764.2 ng/mL (median peak 945.3 ng/mL), respectively. Conclusions: Ace-K and sucralose transfer into breast milk following ingestion of a diet soda. Future research should measure concentrations after repeated exposure and determine whether chronic ingestion of sucralose and acesulfame-potassium via the breast milk has clinically relevant health consequences.
- Published
- 2018