1. Subcortical grey matter structures in multiple sclerosis
- Author
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Naiara Aguirre, Cristina Forn, Álvaro Javier Cruz-Gómez, César Ávila, and Carla Sanchis-Segura
- Subjects
cognition ,Adult ,Male ,Pathology ,medicine.medical_specialty ,Multiple Sclerosis ,Thalamus ,Neuropsychological Tests ,Grey matter ,050105 experimental psychology ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Atrophy ,thalamus ,Basal ganglia ,Humans ,Medicine ,Cognitive Dysfunction ,0501 psychology and cognitive sciences ,Gray Matter ,functional connectivity (FC) ,medicine.diagnostic_test ,business.industry ,General Neuroscience ,Multiple sclerosis ,05 social sciences ,Brain ,Magnetic resonance imaging ,Cognition ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,multiple sclerosis (MS) ,medicine.anatomical_structure ,grey matter (GM) ,basal ganglia ,Female ,Orbitofrontal cortex ,business ,030217 neurology & neurosurgery - Abstract
The present study aimed to investigate altered grey matter (GM) and functional connectivity (FC) in deep subcortical areas, like the thalamus and basal ganglia, and their relationship with cognitive impairment in multiple sclerosis (MS). Thirty-six patients were neuropsychologically assessed, classified as cognitive preserved (CP) and cognitive impairment (CI), and were compared with 18 healthy controls (HC). GM atrophy and FC were observed in 10 predefined functional areas of the thalamus and in six of basal ganglia. GM atrophy was prominent in the basal ganglia in CI patients compared to CP MS patients. Increased FC was observed between the right caudate and the bilateral orbitofrontal cortex in CI vs. CP patients. The discriminant and correlation analyses revealed that the enhanced FC observed between the right caudate and the orbitofrontal cortex was closely associated with cognitive impairment in MS patients. In conclusion, reduced GM volume and enhanced fronto-basal ganglia connectivity are related to cognition in MS patients.
- Published
- 2018
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