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3 results on '"Urinary Bladder Neoplasms/drug therapy"'

2. A Rare Case of Granulomatous Pneumonitis Due to Intravesical BCG for Bladder Cancer

Author

Vera Clérigo, Ana Castro, Teresa Mourato, and Conceição Gomes

Subjects
BCG Vaccine, Granuloma/chemically induced, Pneumonia/chemically induced, Urinary Bladder Neoplasms/drug therapy, Medicine, Medicine (General), R5-920
Abstract

Granulomatous pneumonitis is a rare complication of bacillus Calmette-Guerin immunotherapy following intravesical administration of bacillus Calmette-Guerin. The authors present an unusual case of a 67-year-old man who developed mild and non-specific symptoms, following intravesical bacillus Calmette-Guerin instillations. Examinations revealed features of miliary tuberculosis and granuloma suggestive of mycobacterial infection. Anti-tuberculosis treatment resulted in a remarkable improvement in his symptoms and gradually upgrading of radiological appearance. The symptoms were less severe than some others described but this case provides evidence that, even in some cases, specific treatment may be necessary. We highlight the importance of recognizing miliary Mycobacterium bovis as a probable complication of bacillus Calmette-Guerin immunotherapy. The clinical disease course can be mild, despite extensive bilateral miliary nodules on primary presentation.

Published
2019
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3. A Rare Case of Granulomatous Pneumonitis Due to Intravesical BCG for Bladder Cancer

Author

Ana C. Meira Castro, Vera Clérigo, Conceição Gomes, and Teresa Mourato

Subjects
medicine.medical_specialty, Miliary tuberculosis, medicine.medical_treatment, lcsh:Medicine, 03 medical and health sciences, 0302 clinical medicine, Medicine, Pneumonitis, lcsh:R5-920, Mycobacterium bovis, Bladder cancer, Urinary Bladder Neoplasms/drug therapy, biology, business.industry, Pneumonia/chemically induced, lcsh:R, General Medicine, Immunotherapy, medicine.disease, biology.organism_classification, Dermatology, Granuloma/chemically induced, 030228 respiratory system, 030220 oncology & carcinogenesis, Granuloma, BCG Vaccine, lcsh:Medicine (General), business, Complication, BCG vaccine
Abstract

Granulomatous pneumonitis is a rare complication of bacillus Calmette-Guerin immunotherapy following intravesical administration of bacillus Calmette-Guerin. The authors present an unusual case of a 67-year-old man who developed mild and non-specific symptoms, following intravesical bacillus Calmette-Guerin instillations. Examinations revealed features of miliary tuberculosis and granuloma suggestive of mycobacterial infection. Anti-tuberculosis treatment resulted in a remarkable improvement in his symptoms and gradually upgrading of radiological appearance. The symptoms were less severe than some others described but this case provides evidence that, even in some cases, specific treatment may be necessary. We highlight the importance of recognizing miliary Mycobacterium bovis as a probable complication of bacillus Calmette-Guerin immunotherapy. The clinical disease course can be mild, despite extensive bilateral miliary nodules on primary presentation.

Published
2019

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