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This scoping literature review will explore the efficacy and safety of ivermectin and doxycycline when used as monotherapy and as combination for treating confirmed cases of COVID-19.

With an improvement in the realisation of the importance of collecting patient-reported outcomes (PROs), sponsors of randomized controlled trials (RCTs) around the world have started incorporating questions related to Quality of Life (QoL) and other PRO measures routinely. Some regulators also have actively started looking for changes in QoL after an intervention, in addition to the routinely collected disease-related measures. We are interested to measure the extent to which QoL information is collected in RCTs from India, and for analysing the same, we have planned this systematic literature review.

Hydroxychloroquine (HCQ) has recently gained significant interest across the world for its possible role as an antiviral drug against the SARS-CoV2 in the fight against COVID-19. HCQ is a derivative of the antimalarial drug chloroquine, and is used for a wide variety of indications including rheumatoid arthritis, lupus erythematosus, and malaria, apart from being used off-label (either alone or in combination with various drugs) to treat various conditions such as dermatomyositis, porpyria cutanea tarda, Sjögren's syndrome, Q fever, and sarcoidosis. Given the varied nature of conditions being treated using HCQ, the question as to whether HCQ has a broad-spectrum antiviral property requires to be answered using a systematic literature review. This scoping review is being done to fulfil the knowledge gap in this area, and to evaluate the published literature describing the antiviral activity of hydroxychloroquine.

Poor medication adherence is associated with poor treatment outcomes. Attempts have been made to improve medication adherence through multiple means. The objectives of this scoping systematic literature review is to explore the existing literature for evidence on the impact of rewards, and gamification on improving medication adherence across multiple disease conditions.

Many studies that evaluate the patterns of chemotherapy and immunotherapy of breast cancer are available in literature, which source the information from randomized control trials (RCTs) and observational studies. However, the real-world evaluation of the treatment patterns in the form of registry analysis, and the treatment outcomes, needs to be summarized. In this review our aim is to evaluate the different types of treatment patters of breast cancer and their effects on patient outcomes in the analysis of breast cancer registries.