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Peptides have fantastic functions like defensins that make up the natural defense in different species from vertebrates to bacteria. Another fantastic example are prions that cause transmissible diseases devoid of nucleic acid. So, because of their high specificity, peptides can be used for different therapeutic goals. In this work we describe in vitro action of a peptide named L18R this sequence is part of a group of four distinct sequences that were previously tested and showed activity against fungi and tumors, which motivated us to investigate this activity against murine B16F10 melanoma. Thus, has been demonstrated that L18R had activity against tumor, for interfering in cell viability, migration and in cell cycle. To conclude, the present work suggests a functional molecule against tumor.