1. Acute Upper Gastrointestinal Bleeding from Gastric Involvement of Chronic Lymphocytic Leukemia: A Case Report
- Author
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Gerald Langman, Alexander Daley, Marcus Mottershead, and Nwe Ni Than
- Subjects
CD20 ,Pathology ,medicine.medical_specialty ,Gastrointestinal bleeding ,biology ,medicine.diagnostic_test ,business.industry ,Chronic lymphocytic leukemia ,Stomach ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,immune system diseases ,hemic and lymphatic diseases ,030220 oncology & carcinogenesis ,Biopsy ,medicine ,biology.protein ,Immunohistochemistry ,Bone marrow ,CD5 ,business ,030215 immunology - Abstract
Gastrointestinal involvement of chronic lymphocytic leukaemia (CLL) is uncommon and acute GI bleeding as a result of CLL involvement is much rarer. We report a 77-year-old lady with known history of chronic lymphocytic leukaemia (CLL) presented to emergency department with haematemesis and melaena. Upper gastrointestinal endoscopy showed large necrotic looking area in the stomach with bleeding from necrotic area. Biopsies showed lymphoid infiltration and immunohistochemistry showed CD20+, CD5+, Cyclin D1- and CD23- which were similar findings to CLL from bone marrow biopsy.
- Published
- 2017