1. GSNOR regulates cardiomyocyte differentiation and maturation through protein S-nitrosylation
- Author
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Richard T. Premont, Nicholas M. Venetos, Jonathan S. Stamler, and Zachary W. Grimmett
- Subjects
chemistry.chemical_classification ,Enzyme ,chemistry ,Protein S-nitrosylation ,Cardiomyocyte differentiation ,Reductase ,Progenitor cell ,Induced pluripotent stem cell ,Developmental biology ,Article ,Cell biology - Abstract
S-nitrosoglutathione reductase (GSNOR) is a denitrosylase enzyme responsible for reverting protein S-nitrosylation (SNO). In this issue, Salerno et al. [1] provide evidence that GSNOR deficiency - and thus elevated protein S-nitrosylation - accelerates cardiomyocyte differentiation and maturation of induced pluripotent stem cells (iPSCs). GSNOR inhibition (GSNOR-/- iPSCs) expedites the epithelial-mesenchymal transition (EMT) and promotes cardiomyocyte progenitor cell proliferation, differentiation, and migration. These findings are consistent with emerging roles for protein S-nitrosylation in developmental biology (including cardiomyocyte development), aging/longevity, and cancer.
- Published
- 2021
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