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A research study conducted at Harbin Medical University in China investigated the efficacy of alanyl-glutamine combined with ulinastatin for severe acute pancreatitis (SAP) with lung injury and its impact on inflammation and immune function. The study involved 90 patients with SAP and lung injury who were divided into control and study groups. The results showed that the combination treatment led to a shorter time of clinical symptom improvement, decreased lung injury scores, increased oxygen levels, decreased inflammatory markers, and improved immune function. The researchers concluded that alanyl-glutamine combined with ulinastatin can enhance the efficacy of treatment for SAP with lung injury and improve patients' immune function. [Extracted from the article]

A recent study conducted by researchers from Konkuk University in Seoul, South Korea, explored the preventive effect of ulinastatin, a urinary trypsin inhibitor, on postoperative cognitive dysfunction (POCD) in rats under general anesthesia. The study used a Y-maze test to evaluate cognitive function and examined neuronal damage, inflammation levels, and microglial activation. The results showed that administering ulinastatin before general anesthesia prevented cognitive decline and neuronal damage, with a significant reduction in microglial activation. The study suggests that ulinastatin may have a protective effect on cognitive function during anesthesia. [Extracted from the article]

A recent study conducted in Baoji, China, explored the effects of Xingnaojing Injection combined with ulinastatin and continuous renal replacement therapy (CRRT) on septic patients with acute kidney injury (AKI). The study involved 104 septic patients with AKI who were randomly assigned to either an observation group or a control group. The results showed that the observation group, which received Xingnaojing Injection in addition to ulinastatin and CRRT, had significantly higher efficacy rates compared to the control group. The study concluded that this combination therapy effectively improved immune function and hemodynamics in septic patients with AKI. [Extracted from the article]

Researchers from the Department of Anesthesia in Shaanxi, People's Republic of China, conducted a study to investigate the effect of early resuscitation using a combination of lactated Ringer's solution and ulinastatin on the survival rate of patients with sepsis. The study included 82 patients with septic shock and found that the combination treatment significantly improved the patients' condition by reducing inflammation, enhancing renal function, and increasing the short-term survival rate. The findings provide valuable information for exploring new therapeutic approaches to sepsis. The research was published in the Tropical Journal of Pharmaceutical Research. [Extracted from the article]

A study conducted at the First Affiliated Hospital explored the therapeutic role of ulinastatin (UTI) in treating colitis, an inflammatory bowel disease. The researchers induced colitis in mice and treated a subgroup with UTI. They found that UTI significantly alleviated inflammation and intestinal barrier damage in the mice. The study also revealed a correlation between UTI treatment and the JAK-STAT signaling pathway, as well as the maintenance of a stable intestinal flora and the production of bile acids and short-chain fatty acids. The findings suggest that UTI may be effective in treating colitis and could be used as a potential treatment for patients with ulcerative colitis. [Extracted from the article]

A study conducted in Jiangsu, People's Republic of China, explored the effects of an intravenous infusion of lidocaine combined with ulinastatin on perioperative analgesia and recovery for pancreatic cancer patients undergoing laparoscopic surgery. The group receiving ulinastatin had lower postoperative extubation time, time of stay in the recovery room after anesthesia, gastrointestinal function recovery time, and hospital stay compared to the control group. Additionally, the group receiving ulinastatin experienced decreased pain scores and lower levels of pro-inflammatory cytokines. The study concluded that ulinastatin improves perioperative analgesia and postoperative recovery for pancreatic cancer patients without additional side effects during laparoscopic-assisted surgery. [Extracted from the article]

A recent study conducted at the Third Affiliated Hospital investigated the protective effect of ulinastatin on the intestinal mucosal barrier in mice with sepsis. The researchers focused on the TLR4/MyD88/NF-kB signaling pathway and found that ulinastatin may protect the intestinal mucosal barrier against sepsis through this pathway. The study involved a mouse model of sepsis and measured levels of TNF-a, IL-6, and IL-1b, as well as the expression of TLR4, MyD88, and NF-kB mRNA. The findings suggest that ulinastatin's protective effect on the intestinal mucosal barrier may be mediated through the TLR4/MyD88/NF-kB pathway. [Extracted from the article]

A new study from the Department of Anesthesiology in Hebei, China, explores the effect of combining sevoflurane and ulinastatin on the proliferation and migration of lung adenocarcinoma cells. The researchers found that the combination treatment significantly inhibited cell proliferation and migration in a dose-dependent manner. They also observed a decrease in the expression of proteins associated with proliferation and migration. The study suggests that sevoflurane combined with ulinastatin may have potential as a treatment for lung adenocarcinoma. [Extracted from the article]

Therefore, reasonable use of delayed graft function after renal transplantation to promote renal function recovery is of great significance for the prognosis of these patients." Keywords: Beijing; People's Republic of China; Asia; Biomarkers; Delayed Graft Function; Diagnostics and Screening; Gastroenterology; Health and Medicine; Kidney; Kidney Function; Nephrology; Renal Function; Risk and Prevention EN Beijing People's Republic of China Asia Biomarkers Delayed Graft Function Diagnostics and Screening Gastroenterology Health and Medicine Kidney Kidney Function Nephrology Renal Function Risk and Prevention 5515 5515 1 10/16/23 20231020 NES 231020 2023 OCT 20 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Week -- A new study on Delayed Graft Function is now available. [Extracted from the article]

In some embodiments, the ulinastatin polypeptide has a specific activity of about or at least about 1000-3000 U/mg, or about or at least about 1000, 1100, 1200, 1300, 1400, 1500, 1600, 1700, 1800, 1900, 2000, 2100, 2200, 2300, 2400, 2500, 2600, 2700, 2800, 2900, or 3000 U/mg, wherein one unit (U) is an amount of the ulinastatin polypeptide that inhibits the activity of 2 mg trypsin by 50%. The isolated, mature ulinastatin polypeptide of claim 1, wherein the ulinastatin polypeptide has a specific activity of at least about 1000 U/mg, wherein one unit (U) is an amount of the ulinastatin polypeptide that inhibits the activity of 2 mg trypsin by 50%. Some compositions comprise a mixture of (a) the isolated, mature ulinastatin polypeptide described herein, and (b) a second, mature ulinastatin polypeptide that comprises an N-linked glycan at residue N45 and does not comprise an O-linked glycan at residue T17, wherein (a) and (b) have at least one ulinastatin activity. [Extracted from the article]

Keywords for this news article include: Beijing, People's Republic of China, Asia, Acute Kidney Injury, Cardiac Surgery, Cardiology, Cardiopulmonary Bypass, Gastroenterology, Health and Medicine, Hospitals, Kidney, Kidney Diseases and Conditions, Kidney Function, Nephrology, Renal Function, Fuwai Hospital. Keywords: Beijing; People's Republic of China; Asia; Acute Kidney Injury; Cardiac Surgery; Cardiology; Cardiopulmonary Bypass; Gastroenterology; Health and Medicine; Hospitals; Kidney; Kidney Diseases and Conditions; Kidney Function; Nephrology; Renal Function EN Beijing People's Republic of China Asia Acute Kidney Injury Cardiac Surgery Cardiology Cardiopulmonary Bypass Gastroenterology Health and Medicine Hospitals Kidney Kidney Diseases and Conditions Kidney Function Nephrology Renal Function 293 293 1 08/07/23 20230807 NES 230807 2023 AUG 7 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- Current study results on Kidney Diseases and Conditions - Acute Kidney Injury have been published. [Extracted from the article]

Keywords: Antiretrovirals; Aortic Dissection; Artificial Intelligence; Cardiology; Cardiovascular Diseases and Conditions; Drugs and Therapies; Emerging Technologies; Health and Medicine; Machine Learning; Pharmaceuticals; Pharmacotherapy; Therapy; Ulinastatin Therapy EN Antiretrovirals Aortic Dissection Artificial Intelligence Cardiology Cardiovascular Diseases and Conditions Drugs and Therapies Emerging Technologies Health and Medicine Machine Learning Pharmaceuticals Pharmacotherapy Therapy Ulinastatin Therapy 142 142 1 07/10/23 20230710 NES 230710 2023 JUL 10 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- Current study results on artificial intelligence have been published. According to news originating from Nanjing, People's Republic of China, by NewsRx correspondents, research stated, "The systemic benefits of anti-inflammatory pharmacotherapy vary across cardiovascular diseases in clinical practice.". [Extracted from the article]

Hebei, People's Republic of China, Asia, Antiretrovirals, Drugs and Therapies, Health and Medicine, Infectious Disease, Lung Diseases and Conditions, Pediatrics, Pharmaceuticals, Pneumonia, Pulmonology, Respiratory Tract Diseases and Conditions, Respiratory Tract Infections, Ulinastatin Therapy Keywords: Hebei; People's Republic of China; Asia; Antiretrovirals; Drugs and Therapies; Health and Medicine; Infectious Disease; Lung Diseases and Conditions; Pediatrics; Pharmaceuticals; Pneumonia; Pulmonology; Respiratory Tract Diseases and Conditions; Respiratory Tract Infections; Ulinastatin Therapy EN Hebei People's Republic of China Asia Antiretrovirals Drugs and Therapies Health and Medicine Infectious Disease Lung Diseases and Conditions Pediatrics Pharmaceuticals Pneumonia Pulmonology Respiratory Tract Diseases and Conditions Respiratory Tract Infections Ulinastatin Therapy 110 110 1 05/02/23 20230505 NES 230505 2023 MAY 6 (NewsRx) -- By a News Reporter-Staff News Editor at Pediatrics Week -- New research on Lung Diseases and Conditions - Pneumonia is the subject of a report. Keywords for this news article include: Asia, Antiretrovirals, Pharmaceuticals, Hebei, Pneumonia, Pediatrics, Pulmonology, Infectious Disease, Drugs and Therapies, Health and Medicine, Ulinastatin Therapy, People's Republic of China, Lung Diseases and Conditions, Respiratory Tract Infections, Respiratory Tract Diseases and Conditions. [Extracted from the article]

Ulinastatin (UTI) mainly inhibits proteolytic activity and significantly reduces the release of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) from macrophages." Tianjin, People's Republic of China, Asia, Amino Acids, Arginine, Basic Amino Acids, Diamino Amino Acids, Essential Amino Acids, Health and Medicine, Intercellular Signaling Peptides and Proteins, Membrane Proteins, Obstetrics, Preeclampsia, Pregnancy Complications, Tumor Necrosis Factors, Women's Health Keywords: Tianjin; People's Republic of China; Asia; Amino Acids; Arginine; Basic Amino Acids; Diamino Amino Acids; Essential Amino Acids; Health and Medicine; Intercellular Signaling Peptides and Proteins; Membrane Proteins; Obstetrics; Preeclampsia; Pregnancy Complications; Tumor Necrosis Factors; Women's Health EN Tianjin People's Republic of China Asia Amino Acids Arginine Basic Amino Acids Diamino Amino Acids Essential Amino Acids Health and Medicine Intercellular Signaling Peptides and Proteins Membrane Proteins Obstetrics Preeclampsia Pregnancy Complications Tumor Necrosis Factors Women's Health 369 369 1 03/27/23 20230331 NES 230331 2023 MAR 30 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Fresh data on Membrane Proteins - Tumor Necrosis Factors are presented in a new report. [Extracted from the article]

Antiretrovirals, Biological Factors, Biological Tumor Markers, Blood Coagulation Factors, Blood Transfusion, Bradykinin, Cardiology, Cardiovascular Diseases and Conditions, Cardiovascular Diseases and Conditions - Reperfusion Injury, Cardiovascular Physiological Phenomena, Cardiovascular Surgical Procedures, Cell Biology, Chemicals, Drugs and Therapies, Enzymes and Coenzymes, Health and Medicine, Hematology, Hemodynamics, Inflammation, Intercellular Signaling Peptides and Proteins, Ischemia, Ischemia-Reperfusion Injury, Kallikrein-Kinin System, Kallikreins, Kinins, Medical Devices, Nitric Oxide, Peptide Hydrolases, Pharmaceuticals, Reperfusion, Reperfusion Injury, Risk and Prevention, Serine Endopeptidases, Surgery, Synthase, Transfusion Medicine, Ulinastatin Therapy, Vascular Diseases and Conditions, Tissue Kallikreins. [Extracted from the article]

Cell proliferation, migration, invasion, and apoptosis were determined by cell counting kit-8 (CCK-8), colony formation, wound-healing, Transwell assay, and flow cytometry analysis, respectively. Keywords: Shanghai; People's Republic of China; Asia; Antiretrovirals; Apoptosis; Cancer; Cell Proliferation; Cellular Physiology; Drugs and Therapies; Health and Medicine; Oncology; Pharmaceuticals; Prostate Cancer; Prostatic Neoplasms; Ulinastatin Therapy EN Shanghai People's Republic of China Asia Antiretrovirals Apoptosis Cancer Cell Proliferation Cellular Physiology Drugs and Therapies Health and Medicine Oncology Pharmaceuticals Prostate Cancer Prostatic Neoplasms Ulinastatin Therapy Investigators publish new report on Oncology - Prostate Cancer. [Extracted from the article]