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A study conducted by researchers at Hamamatsu University School of Medicine in Japan has investigated the gender-specific distribution of drugs and their metabolites in mice kidney tissues. The study used atmospheric pressure matrix-assisted laser desorption ionization-mass spectrometry imaging (AP-MALDI-MSI) to analyze the distribution of imipramine, chloroquine, and their metabolites in male and female kidneys. The results showed differential distributions of the drugs and metabolites between male and female kidneys, providing valuable insights for personalized medicine and reducing toxicity. This research contributes to the understanding of gender-specific drug distributions in different organs. [Extracted from the article]

A new report from Hamamatsu University in Shizuoka, Japan, presents fresh data on hemofiltration in dialysis patients. The study aimed to analyze the adsorbed proteins in two different types of dialysis membranes, polymethyl methacrylate (PMMA) and polyethersulfone (PES), in patients undergoing predilution online hemodiafiltration (OL-HDF). The researchers found that the PMMA membrane exhibited higher adsorption of certain proteins, such as beta 2 microglobulin and interleukin-6, compared to the PES membrane. These findings suggest that PMMA-based OL-HDF therapy may be useful in controlling inflammatory status in patients with end-stage kidney disease. [Extracted from the article]

A recent study conducted at Hamamatsu University School of Medicine in Japan has explored the use of mass spectrometry imaging (MSI) combined with dimensionality reduction methods to examine the distribution and impact of the tricyclic antidepressant imipramine on endogenous metabolites in the brains of mice. The researchers found that the sparse autoencoder (SAE) method was particularly effective in identifying phosphorylcholine (ChoP) as a potential marker distinguishing between control and treated mice brains. They also observed a significant decrease in ChoP accumulation in various regions of the treated mice brains. This novel approach to data analysis shows promise for future research in this field. [Extracted from the article]

A new report from Hamamatsu University School of Medicine in Japan discusses the interaction between nerve tissue proteins and the role of microsomal glutathione S-transferase 3 (MGST3) in promoting this interaction. The study found that MGST3 upregulates the interaction between alpha-synuclein (a-syn) and ubiquitin-like 3 (UBL3), leading to increased extracellular transport of a-syn. These findings provide insights into the potential therapeutic use of UBL3 modulation for synucleinopathy-associated neurodegenerative diseases. The research was funded by the Japan Society For The Promotion of Science Grant-in-aid For Scientific Research and the Japan Agency For Medical Research And Development. [Extracted from the article]

A systematic review conducted by researchers at Hamamatsu University School of Medicine explores the potential of lipid profiling through mass spectrometry (MS) as a prognostic tool for cancer patients. The review summarizes 38 studies from the past decade that utilized lipidomics to predict the prognosis of cancer patients. The most commonly analyzed cancers were colorectal, prostate, and breast cancers, and liquid chromatography-tandem MS was the most frequently used analytical platform. The review identified 38 lipid markers that showed potential as prognostic factors, but further research is needed to validate and establish these markers as reliable tools in clinical practice. [Extracted from the article]

Keywords for this news article include: Hamamatsu, Japan, Asia, Nerve Tissue Proteins, Proteins, Synucleins, alpha-Synuclein, Hamamatsu University. Keywords: Hamamatsu; Japan; Asia; Nerve Tissue Proteins; Proteins; Synucleins; alpha-Synuclein EN Hamamatsu Japan Asia Nerve Tissue Proteins Proteins Synucleins alpha-Synuclein 540 540 1 10/30/23 20231103 NES 231103 2023 NOV 3 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Data detailed on Proteins - Nerve Tissue Proteins have been presented. [Extracted from the article]

Shizuoka, Japan, Asia, Acetaminophen Therapy, Acetanilides, Amino Acids, Anilides, Cysteine, Drugs and Therapies, Health and Medicine, Kidney, Nephrology, Neutral Amino Acids, Pharmaceuticals, Pharmacokinetics, Pharmacology, Sulfhydryl Compounds, Sulfur Amino Acids Keywords for this news article include: Shizuoka, Japan, Asia, Acetaminophen Therapy, Acetanilides, Amino Acids, Anilides, Cysteine, Drugs and Therapies, Health and Medicine, Kidney, Nephrology, Neutral Amino Acids, Pharmaceuticals, Pharmacokinetics, Pharmacology, Sulfhydryl Compounds, Sulfur Amino Acids, Hamamatsu University. Keywords: Shizuoka; Japan; Asia; Acetaminophen Therapy; Acetanilides; Amino Acids; Anilides; Cysteine; Drugs and Therapies; Health and Medicine; Kidney; Nephrology; Neutral Amino Acids; Pharmaceuticals; Pharmacokinetics; Pharmacology; Sulfhydryl Compounds; Sulfur Amino Acids EN Shizuoka Japan Asia Acetaminophen Therapy Acetanilides Amino Acids Anilides Cysteine Drugs and Therapies Health and Medicine Kidney Nephrology Neutral Amino Acids Pharmaceuticals Pharmacokinetics Pharmacology Sulfhydryl Compounds Sulfur Amino Acids 1766 1766 1 07/17/23 20230721 NES 230721 2023 JUL 21 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Week -- Investigators discuss new findings in Drugs and Therapies - Acetaminophen Therapy. [Extracted from the article]

Cytochrome P450 3A Inhibitors, Drugs and Therapies, Epidermal Growth Factor Receptor, Epidermal Growth Factors, Gastrointestinal Hormone Receptors, Gastrointestinal Hormones, Growth Factor Receptors, Intercellular Signaling Peptides and Proteins, Kinase Inhibitors, Membrane Proteins, Nerve Tissue Proteins, Osimertinib Therapy, Pharmaceuticals, Phosphotransferases, Protein Kinases, Proteins, Receptor Protein-Tyrosine Kinases, Synucleins, alpha-Synuclein Keywords: Cytochrome P450 3A Inhibitors; Drugs and Therapies; Epidermal Growth Factor Receptor; Epidermal Growth Factors; Gastrointestinal Hormone Receptors; Gastrointestinal Hormones; Growth Factor Receptors; Intercellular Signaling Peptides and Proteins; Kinase Inhibitors; Membrane Proteins; Nerve Tissue Proteins; Osimertinib Therapy; Pharmaceuticals; Phosphotransferases; Protein Kinases; Proteins; Receptor Protein-Tyrosine Kinases; Synucleins; alpha-Synuclein EN Cytochrome P450 3A Inhibitors Drugs and Therapies Epidermal Growth Factor Receptor Epidermal Growth Factors Gastrointestinal Hormone Receptors Gastrointestinal Hormones Growth Factor Receptors Intercellular Signaling Peptides and Proteins Kinase Inhibitors Membrane Proteins Nerve Tissue Proteins Osimertinib Therapy Pharmaceuticals Phosphotransferases Protein Kinases Proteins Receptor Protein-Tyrosine Kinases Synucleins alpha-Synuclein 2067 2067 1 06/26/23 20230627 NES 230627 2023 JUN 30 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on kinase inhibitors. [Extracted from the article]

Keywords for this news article include: Hamamatsu University School of Medicine, Shizuoka, Japan, Asia, Biology, Putamen, Cerebrum, Neostriatum, Basal Ganglia, Life Sciences, Telencephalon, Brain Research, Prosencephalon, Nucleus Accumbens, Health and Medicine, Central Nervous System. Keywords: Basal Ganglia; Biology; Brain Research; Central Nervous System; Cerebrum; Health and Medicine; Life Sciences; Neostriatum; Nucleus Accumbens; Prosencephalon; Putamen; Telencephalon EN Basal Ganglia Biology Brain Research Central Nervous System Cerebrum Health and Medicine Life Sciences Neostriatum Nucleus Accumbens Prosencephalon Putamen Telencephalon 6299 6299 1 03/23/23 20230303 NES 230303 2023 MAR 3 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on biology is now available. Basal Ganglia, Biology, Brain Research, Central Nervous System, Cerebrum, Health and Medicine, Life Sciences, Neostriatum, Nucleus Accumbens, Prosencephalon, Putamen, Telencephalon. [Extracted from the article]

Cancer New study results on cancer have been published. A variety of sEV proteins thataffects cancer properties has been found to interact with UBL3.An increasing number of studies has implied that UBL3expression affects cancer cell growth and cancer prognosis. [Extracted from the article]