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A new report discusses research findings on cell therapy for cancer treatment. The study focuses on targeting the membrane-proximal C2-set domain of CD33 to improve CAR T cell therapy. The researchers found that decreasing the distance between T cells and leukemia cells' membranes increased the efficacy of CD33 chimeric antigen receptor (CAR) T cells. The study demonstrated improved efficacy with CAR T cells binding CD33 close to the cell membrane, suggesting the potential for further investigation and possible clinical application. The research was conducted at the Fred Hutchinson Cancer Research Center in Seattle, Washington. [Extracted from the article]

A recent systematic review and meta-analysis conducted by researchers from Bahir Dar University aimed to assess the prevalence and determinants of stunting-anemia and wasting-anemia comorbidities and micronutrient deficiencies in children under 5 in the least-developed countries (LDCs). The study found that a significant proportion of children in LDCs experienced these comorbidities and deficiencies, with vitamin A deficiency affecting 16.32% of children and iodine deficiency affecting 43.41% of children. The study highlights the urgent need to address the factors driving these burdens. The research was published in Nutrition Reviews and was funded by Australia National University. [Extracted from the article]

A recent study conducted by the Australian National University explores the relationship between work hours and mental health among older Australian workers aged 50-70 years. The study found that there is a tipping point of 39-40 work hours per week, beyond which mental health and vitality decline. However, this threshold varies depending on overall health and occupation, with blue- and pink-collar jobs having lower limits compared to white-collar jobs. The research emphasizes that age is not the primary factor limiting work hours for older adults, but rather their health and the nature of their jobs. [Extracted from the article]

A recent report from the University of Sydney discusses the use of histone methylation mark analyses to distinguish chimeric antigen receptor-modified T cell (CART) therapy products manufactured from different sources. The researchers found that histone mark analyses were able to identify genes associated with T cell differentiation and CART cell expansion that were not identified by RNA sequencing. Additionally, histone mark analyses were able to distinguish CART products that were associated with higher CART cell counts in patient blood after infusion. This study highlights the potential of histone mark analyses to improve outcomes in CART immunotherapy. [Extracted from the article]

Canberra, Australia, Australia and New Zealand, Health and Medicine, Mental Health Diseases and Conditions Keywords: Canberra; Australia; Australia and New Zealand; Health and Medicine; Mental Health Diseases and Conditions EN Canberra Australia Australia and New Zealand Health and Medicine Mental Health Diseases and Conditions 592 592 1 09/04/23 20230908 NES 230908 2023 SEP 4 (NewsRx) -- By a News Reporter-Staff News Editor at Mental Health Weekly Digest -- Investigators discuss new findings in Mental Health Diseases and Conditions. [Extracted from the article]