Search

A recent study conducted at Boston Children's Hospital explored the effects of botulinum neurotoxin serotype A (BoNT/A) on ocular angiogenesis, a process that can lead to vision loss in certain eye conditions. The researchers found that BoNT/A inhibited the growth of abnormal blood vessels in the eye by modulating glial cell activation and the release of growth factors. The study also highlighted the role of neuronal and glial suppressor of cytokine signaling 3 (SOCS3) in this process. The findings suggest that BoNT/A could be a potential therapeutic intervention for pathological angiogenesis in retinopathies. [Extracted from the article]

Researchers at Boston Children's Hospital have conducted a study on the cellular and molecular mechanisms involved in pathological ocular angiogenesis, or the formation of abnormal blood vessels in the eye. They found that the absence of a protein called suppressor of cytokine signaling 3 (SOCS3) in myeloid cells led to an accumulation of microglia and macrophages during the neovascularization process. The researchers also identified a gene called secreted phosphoprotein 1 (Spp1) that was highly expressed in these microglia and macrophages. Activation of SOCS3 or blocking Spp1 resulted in a significant reduction in pathological neovascularization. This study highlights the role of the SOCS3/STAT3/Spp1 axis in regulating pathological retinal angiogenesis. [Extracted from the article]

A recent study conducted at Brigham and Women's Hospital in Boston, Massachusetts has identified a novel gene, FAM222A, that plays a key role in endothelial biology and angiogenesis. The study found that FAM222A is regulated by BRD4, a protein involved in transcriptional responses induced by pathogenic stimuli. The researchers used RNA-Seq data to analyze the effects of BET inhibition on endothelial cells and found that silencing FAM222A decreased cellular proliferation, migration, and angiogenesis, while overexpression had the opposite effects. These findings suggest that FAM222A could be a potential target for therapeutic interventions in cardiovascular diseases. [Extracted from the article]

A recent study conducted at Boston Children's Hospital explored the role of photoreceptors in regulating abnormal blood vessel growth in retinal diseases. The study found that the depletion of c-Fos, a protein expressed in rod photoreceptors, inhibited pathological neovascularization and reduced blood vessel leakage in a mouse model. The researchers also demonstrated the therapeutic potential of using gene therapy to target c-Fos, which effectively mitigated abnormal blood vessel growth and improved retinal function. This study provides a novel perspective for the treatment of retinal diseases and highlights the significance of photoreceptor c-Fos in retinopathy of prematurity. [Extracted from the article]

Researchers at South China University of Technology have developed a high-power ultrafast fiber laser system that generates ultrashort pulses with a repetition rate of 1.2 GHz. The system has two switchable modes: a 1064-nm fundamental laser mode with a maximum output power of 66.6 W, and a 1125-nm Raman laser mode with a maximum output power of 17.23 W. The researchers also investigated a method to switch between the two modes by manipulating the duty cycle of the modulation signal. This bi-mode ultrafast fiber laser system has potential applications in micromachining, bioimaging, and spectroscopy. [Extracted from the article]

Keywords: Cardiovascular Diseases and Conditions; Cybersecurity; Health and Medicine; Hematology; Inflammation; Vascular Diseases and Conditions EN Cardiovascular Diseases and Conditions Cybersecurity Health and Medicine Hematology Inflammation Vascular Diseases and Conditions 790 790 1 08/14/23 20230817 NES 230817 2023 AUG 14 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- Investigators discuss new findings in vascular diseases and conditions. Cardiovascular Diseases and Conditions, Cybersecurity, Health and Medicine, Hematology, Inflammation, Vascular Diseases and Conditions. [Extracted from the article]