Dextromethorphan inhibits microglial activation and thus neurotoxicity. Inflammation mediated neurodegeneration involves activation of the brain's resident immune cells, the microglia, which produce pro-inflammatory and neurotoxic factors including cytokines, reactive oxygen intermediates, nitric oxide, and eicosanoids that impact on neurons to induce neurodegeneration. Hence, identification of compounds that prevent microglial activation may be highly desirable in the search for therapeutic agents for inflammation mediated neurodegenerative diseases. In this study, researchers report that dextromethorphan (DM), an ingredient widely used in anti-tussive remedies, reduced the inflammation mediated degeneration of dopaminergic neurons through inhibition of microglial activation. The neuroprotective effect of DM was attributed to inhibition of LPS stimulated microglial activation because DM significantly inhibited the LPS induced production of tumor necrosis factor-alpha, nitric oxide, and superoxide free radicals. Researcher Y.X. Liu and coauthors published their study in the 'Journal of Pharmacology and Experimental Therapeutics.'