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A study conducted by the University of Toronto explores the effectiveness and safety of a new stimulation paradigm called Differential Target Multiplexed Spinal Cord Stimulation (DTM SCS) for chronic pain management. The study aims to evaluate the impact of DTM SCS on patients with Persistent Spinal Pain Syndrome Type II through a 12-month multicentre cohort study. The primary effectiveness endpoint is overall pain intensity, with various secondary outcome measures being assessed. The research findings will be disseminated through peer-reviewed publications and presentations to clinical audiences. [Extracted from the article]

The patent issued for systems and methods for orthopedic implants by Carlsmed Inc. describes patient-specific orthopedic implants and efficient methods for their production. The orthopedic implants aim to replace missing anatomy, correct deformities, and restore compromised anatomical relationships. The process involves creating user accounts, obtaining patient data, generating anatomical models, designing implants, receiving feedback from healthcare providers, and manufacturing the patient-specific orthopedic implants. The use of software throughout the design process is highlighted, emphasizing the importance of patient consent and healthcare provider approval in the creation of these implants. [Extracted from the article]

A patent has been issued for a medical implant designed by Spinal Simplicity LLC to address spinal stenosis, a condition that causes pain and numbness in the back and legs. The implant aims to stabilize the spine by clamping onto nearby bony tissue or soft tissue, reducing the need for extensive bone or soft tissue removal during surgery. The implant features a single actuation mechanism to simplify the surgical procedure and decrease the complexity of the implant. This innovation may offer a less invasive and more efficient solution for patients undergoing spinal procedures. [Extracted from the article]

A report from Tufts Medical Center in Boston, Massachusetts, discusses the impact of pedicle screw-associated violation of the adjacent unfused facet joint on clinical outcomes and fusion rates in patients undergoing single-level lumbar fusion surgery. The study found that patients with this violation experienced less improvement in back pain, back pain-associated disability, and had a lower fusion rate at 1-year post-surgery compared to those without the violation. This research sheds light on the importance of considering such factors in surgical outcomes for back pain patients. [Extracted from the article]

A patent has been issued to Globus Medical Inc. for devices and methods aimed at correcting vertebral misalignment, particularly conditions like spondylolisthesis. The invention involves vertebral implants that can be used to move dislocated vertebral bodies into proper alignment and maintain stability post-surgery. These devices offer potential solutions for various spinal conditions beyond spondylolisthesis, such as fractures, deformities, degenerative lesions, and post-tumor resection reconstruction. [Extracted from the article]

Spinal Simplicity LLC has been issued a patent for an implant removal tool designed to facilitate the removal of expandable spinal implants. The tool aims to simplify the process of removing implanted surgical devices, particularly in cases where the device needs to be replaced or removed due to failure. This invention provides a combined instrument for preparing and removing the implant, reducing the number of tools required for the surgical procedure and ensuring safe and complete removal from the patient. [Extracted from the article]

The article discusses a clinical trial, NCT06670443, conducted by Cairo University, focusing on the impact of electrical stimulation on respiratory and leg muscles in COPD patients. The trial involves applying neuromuscular stimulation electrode patches over the intercostal respiratory muscles and leg muscles. The study aims to assess various outcomes, including pulmonary function, leg restless syndrome, dyspnea, sleep quality, and quality of life. The trial is currently recruiting participants in Egypt, with specific eligibility criteria for inclusion and exclusion. [Extracted from the article]

A recent study conducted by Cleveland Clinic researchers found that a 12-week therapeutic virtual yoga program can be an effective treatment option for chronic low back pain. Participants in the program reported reduced back pain intensity, improved back-related function, better sleep quality, and decreased use of pain medications. The study, published in JAMA Network Open, highlights the potential benefits of virtual yoga classes as a safe and feasible alternative for managing chronic low back pain. [Extracted from the article]

A study conducted at Singapore General Hospital compared the outcomes of two different minimally invasive surgical techniques for treating degenerative lumbar spinal stenosis. The study found that while the lateral lumbar interbody fusion technique showed superior radiological outcomes, there was no significant difference in clinical outcomes compared to the transforaminal lumbar interbody fusion technique at the two-year follow-up. This suggests that both approaches are reasonable for treating degenerative lumbar spinal stenosis. The study involved 53 patients and was published in the Global Spine Journal. [Extracted from the article]

A recent study conducted at Hamamatsu University in Shizuoka, Japan, focused on the effectiveness of condoliase therapy for lumbar disc herniation (LDH) over a two-year period. The research found that condoliase therapy was effective in 78% of patients with LDH, resulting in improved clinical outcomes and patient satisfaction. The study also observed recovery and maintenance of disc degeneration post-treatment, with no recurrent disc herniation reported. This research provides valuable insights into the long-term outcomes of chemonucleolysis with condoliase for LDH patients. [Extracted from the article]

The article discusses a clinical trial, NCT06651775, focusing on the effectiveness of High Intensity Laser Therapy (HILT) in patients with chronic lumbar radiculopathy due to disc herniation. The study aims to compare the effects of HILT with conventional electrotherapy modalities on pain, disability, and functionality. Participants will undergo 15 sessions of treatment and complete questionnaires before and after treatment. The trial is ongoing and aims to provide insights into the management of chronic low back and leg pain. [Extracted from the article]

A patent application by inventor Min Xiaoyi from Shanghai, China, focuses on a nerve stimulation apparatus, system, and control method for treating chronic pain through spinal cord electrical stimulation. The technology aims to adjust stimulation pulses based on the evoked compound action potential (ECAP) to achieve optimal clinical effects. The system involves a pulse generator, ECAP sensor, and controller to iteratively adjust pulse amplitudes within a comfort range. This innovation offers a potential solution for enhancing the treatment of chronic pain through closed-loop spinal cord electrical stimulation systems. [Extracted from the article]

A patent has been issued for a walking cane designed to provide quick and easy adjustability while offering support and stability to users, particularly the elderly and those with medical conditions. The cane features an expandable and collapsible design with spring-actuated expansion and an internal latch mechanism to lock it at a desired height. The invention aims to address the limitations of standard walking canes by providing a more versatile and user-friendly mobility device. [Extracted from the article]

A study conducted at the Barrow Neurological Institute in Phoenix, Arizona, focused on evaluating the outcomes of lateral lumbar interbody fusion (LLIF) in patients over 75 years old with degenerative spine disease. The research found that patients experienced significant improvements in clinical and radiographic outcomes after the procedure, with most patients showing bony fusion one year postoperatively. The study concluded that LLIF is a safe and effective surgical technique for older patients with degenerative lumbar spine disease. [Extracted from the article]

A clinical trial comparing whole-body electromyostimulation (WB-EMS) to medical therapeutic training (MTT) for non-specific chronic low back pain in middle-aged to older individuals found that strength and stability-oriented training programs can significantly improve low back pain. WB-EMS, a time-effective and joint-friendly technology, was shown to be an effective alternative to conventional back training. The trial aims to assess the effects of WB-EMS versus MTT on pain intensity, disability, trunk strength, lean body mass, and body fat in individuals with chronic low back pain. [Extracted from the article]

The article discusses a randomized clinical trial, NCT06641102, evaluating a digital pain reprocessing therapy for chronic back pain (CBP). The study aims to compare the effectiveness of this new digital treatment with traditional treatments for CBP. The trial will enroll 180 participants who will be randomized into different groups to assess changes in pain intensity. The research team plans to evaluate whether digital therapy is a better option for individuals with CBP who have experienced side effects from other treatments or found previous treatments ineffective. [Extracted from the article]

Researchers Butler and Wolters have submitted a patent application for an "Adjustable Spine Distraction Implant" aimed at addressing spinal stenosis, a condition that narrows the spinal canal and causes pain. The implant is designed to alleviate discomfort associated with the spinal column by relieving pressure on blood vessels and nerves. This innovative implant offers a minimally invasive solution for individuals suffering from spinal stenosis, facet arthropathy, and similar conditions, providing a method for increasing the volume and cross-sectional area of the spinal canal to reduce pain. [Extracted from the article]

A new study conducted at Korea University Anam Hospital in Seoul, South Korea, has investigated the impact of the vacuum phenomenon (VP) on surgical outcomes in patients with lumbar spinal stenosis. The study compared two surgical techniques: minimally invasive oblique lateral interbody fusion (MIS OLIF) and endoscopic decompression. The research found that the presence of the VP may indicate segmental instability and can affect the persistence of radiculopathy. Fusion surgery was found to offer better long-term relief in patients with the VP, while decompression alone was a viable option in non-VP cases. These findings suggest that the VP may be a useful factor in guiding surgical decision-making. [Extracted from the article]

Researchers at ESIC Medical College in Bihar, India have conducted a study on leg pain caused by degenerative lumbar canal stenosis (LCS). The study aimed to validate the radiologic grading of central and foraminal stenosis and correlate it with the outcome after surgical decompression. The researchers found that decompression surgery for degenerative LCS resulted in significant improvement in the Oswestry Disability Index (ODI) and Visual Analog Scale (VAS) for back and leg pain, regardless of the severity of stenosis. The study suggests that preoperative VAS for leg pain can be an indicator of postoperative outcomes. [Extracted from the article]

A recent report from the Institute of Clinical Sciences discusses research findings on compartment syndrome, specifically chronic exertional compartment syndrome (CECS) of the forearm. The study aimed to identify patient characteristics associated with CECS and measure intramuscular pressure (IMP) values in patients with exercise-induced forearm pain. The study found that CECS patients had a higher proportion of males and a history of CECS in the lower legs. The most common occupations and physical activities among CECS patients were office work, craftsperson, strength training, and cycling. The study suggests that the current IMP cutoff value for diagnosing CECS may be too high for the forearm compartments. [Extracted from the article]

A new report from the Faculty of Health Sciences explores the relationship between leg pain and psychosocial factors in patients with chronic venous disease (CVD). The study found that leg pain, central sensitization, and kinesiophobia (fear of movement) are commonly experienced by patients with CVD. Central sensitization was found to have a negative impact on leg pain, kinesiophobia, and body awareness. The researchers suggest that a comprehensive evaluation of these factors is necessary and that rehabilitation strategies should be developed to address them in patients with CVD. [Extracted from the article]

This document provides information about a clinical trial, NCT06615505, conducted by VIVEX Biologics, Inc. in Australia. The trial aims to evaluate the safety and effectiveness of VIA Disc NP, a supplement for degenerated intervertebral discs, in treating chronic low-back pain. The study is a randomized, double-blind, sham-controlled, multi-center trial involving participants with symptomatic lumbar intervertebral disc degeneration. The trial is currently recruiting participants and aims to enroll 110 individuals. The eligibility criteria include being between the ages of 22 and 85, having a diagnosis of early to moderate degenerative disc disease, and experiencing chronic low-back pain for at least 6 months. The trial will assess the proportion of participants who experience a minimally clinically important difference in back pain and the occurrence of treatment-related adverse events. Contact information for the primary investigator is provided. [Extracted from the article]

A patent application has been published online for an interspinous spacer used in spinal surgery. The spacer is designed to alleviate pain associated with spinal stenosis by being implanted between adjacent spinous processes in the spine. It includes various components such as an arm actuator, actuator screw, pins, arms, and a locking ring. The invention allows for different deployment positions of the spacer based on the rotation of the actuator screw. The patent application also mentions a kit that includes the spacer, a spacer insertion instrument, and a driver tool. This information may be valuable for researchers studying spinal surgery and medical device development. [Extracted from the article]

A new report from the Amala Institute of Medical Sciences in Kerala, India, discusses an extremely rare tumor called leiomyoma of the renal capsule. The report presents the case of a 57-year-old female who experienced low backache and right leg pain, and was diagnosed with leiomyoma of the renal capsule. The tumor was unusually large and initially mimicked renal cell carcinoma, but histopathology confirmed it to be leiomyoma. The report suggests that diagnosis is typically made through histopathological examination of surgically removed specimens. [Extracted from the article]

A systematic review conducted by researchers at Sint Maartenskliniek in the Netherlands aimed to identify prognostic factors for the outcome of fusion surgery in patients with chronic low back pain (CLBP). The review analyzed eleven studies and found that only female gender and smoking were consistently associated with the outcome of fusion surgery for CLBP. The researchers noted that most of the included studies had low to moderate methodological quality, which may have contributed to the relatively weak associations identified. Further research is needed to better understand prognostic factors for CLBP surgery outcomes. [Extracted from the article]

A study conducted by investigators from Medtronic in Minneapolis, Minnesota, evaluated the effectiveness of a low-energy differential target multiplexed (DTM) spinal cord stimulation (SCS) derivative in reducing chronic back and/or leg pain. The study included 57 subjects who experienced a 50.4% mean reduction in overall pain from baseline at the 3-month follow-up, which was sustained through 12 months. The use of DTM endurance SCS therapy demonstrated that energy-reducing stimulation patterns can provide clinical benefit and improve quality of life for patients with chronic pain. The research was supported by Medtronic and has been peer-reviewed. [Extracted from the article]

This document provides information about a clinical trial conducted by Columbia University, which aims to investigate the safety and effectiveness of the Discogen device in treating discogenic back and radicular leg pain. The trial will involve 40 participants who will be randomly assigned to receive either the Discogen treatment or a sham treatment. Both treatment arms may include medications such as NSAIDs or muscle relaxants. The trial will assess the effectiveness of the treatment by measuring changes in pain levels and disability index over a period of 60 days. Interested individuals can contact the primary investigator for more information. [Extracted from the article]

This document provides information about a clinical trial, NCT06611332, that aims to evaluate the effectiveness and safety of electroacupuncture as a treatment for lumbar disc herniation with radiculopathy (LDHR). LDHR is a condition characterized by the displacement of the intervertebral disc, causing pain and other symptoms. The trial will involve 170 participants and will compare the effects of electroacupuncture to sham electroacupuncture. The study is currently not recruiting participants and is expected to be completed by October 2025. Participants must meet certain eligibility criteria, including having confirmed intervertebral disc protrusion, radicular pain in the lower extremities, and a certain level of pain intensity. [Extracted from the article]

A recent study conducted by the Sapienza University of Rome explored the efficacy of combining percutaneous laser disc decompression (PLDD) with an oral food supplement for the treatment of lumbar disc herniation. The study divided patients into two groups, with one group receiving PLDD alone and the other group receiving PLDD followed by the dietary supplement for two months after surgery. The results showed that the group receiving the dietary supplement reported significantly better pain relief and improved sensory fiber function compared to the group that only received PLDD. This suggests that the oral food supplement could be a safe and effective treatment option for patients with painful radiculopathy. [Extracted from the article]

A recent study conducted by researchers at the University of California examined the long-term outcomes of surgery for grade 1 spondylolisthesis in obese and non-obese patients. The study found that both obese and non-obese patients experienced similar rates of satisfaction and achieved minimal clinically important differences (MCID) for back pain, disability, and quality of life at the 5-year follow-up. However, obese patients were less likely to achieve MCID for leg pain. The study concluded that both obese and non-obese patients benefit from surgery for grade 1 spondylolisthesis, with similar reoperation rates and outcomes at the 5-year mark. [Extracted from the article]

A new report from Singapore General Hospital compares the clinical outcomes of obese patients undergoing minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) and open TLIF. The study found that obese patients who underwent MIS-TLIF had a shorter length of stay and improved functional disability at two years compared to those who underwent open TLIF. However, patient satisfaction and return to work were comparable between the two groups. The research provides insights into the perioperative benefits of minimally invasive surgery in obese patients. [Extracted from the article]

This document provides information about an ongoing clinical trial (NCT06585033) investigating the use of spinal cord stimulation for the treatment of chronic postoperative pain. The trial aims to enroll 50 participants between the ages of 18 and 70 who have experienced persistent pain for at least 6 months after spinal surgery and have not responded to conservative treatments. Participants will undergo a two-week trial with active test stimulation to assess pain relief before being enrolled in the study. The trial will evaluate the efficacy and safety of spinal cord stimulation in reducing pain and improving quality of life in these patients. The study is expected to be completed by August 31, 2026. [Extracted from the article]

NuVasive Specialized Orthopedics Inc. has been issued a patent for systems and methods for vertebral adjustment. The patent describes a non-invasive adjustable system for changing the curvature of the spine. This system can be used to treat conditions such as degenerative disc disease, back pain, and stenosis. The patent provides detailed information about the design and operation of the adjustable implant, as well as its potential applications in various orthopedic deformities. The patent was filed in January 2023 and published online in September 2024. [Extracted from the article]

A new report discusses the use of trans-sacral epiduroscopic laser decompression (SELD) as a treatment for herniated nucleus pulposus (HNP), a common cause of chronic back pain. The report presents the findings of a retrospective study on 411 patients who underwent SELD for lumbar disc herniation. The study found that SELD was a safe and effective procedure, with significant improvements in pain scores and functional outcomes. The researchers concluded that SELD is a viable treatment option for symptomatic lumbar disc herniation. [Extracted from the article]

This document provides information about a clinical study in Pakistan that aims to compare the effectiveness of two interventions for low back pain associated with foot hyperpronation. The study will compare anti-pronation taping with conventional therapy and short foot exercises with conventional therapy. The study is not yet recruiting participants, but it plans to enroll 40 individuals aged 25 to 45 who have foot hyperpronation and low back pain. The study will measure outcomes such as range of motion, pain levels, foot posture, and disability index. For more information, interested individuals can contact Kinza Anwar. [Extracted from the article]

Researchers from the Department of Acupuncture and Moxibustion Medicine in Seoul, South Korea, have published a case report on the efficacy of integrated Korean medicine treatment for comminuted fractures. The patient in the study received various treatments, including motion-style acupuncture treatment, electroacupuncture, herbal medicine, moxibustion, and cupping therapy, for 112 days. The patient experienced improvements in pain scores, mobility, and radiological scans showed fracture healing. The study suggests that motion-style acupuncture treatment has potential in high-energy polytrauma care, particularly for fractures. [Extracted from the article]

A recent study conducted by researchers at the Affiliated Hospital of Zunyi Medical University in China aimed to analyze the knowledge structure and thematic trends of non-surgical treatments for intervertebral disc degeneration (IDD) using bibliometric analysis. The study found that publications on non-surgical treatment for IDD have been increasing annually, with China and the United States being the dominant contributors. The research identified mesenchymal stem cells, exosomes, medication, and tissue engineering as the current research hotspots in this field. The study provides a comprehensive overview and highlights important future directions for the field of non-surgical treatment for IDD. [Extracted from the article]

A recent study conducted by the Department of Neurosurgery proposes a new technique called the "insert and revolve" technique for inserting large cages during unilateral biportal endoscopic assisted fusion surgery. The study included 104 patients who underwent this procedure and were followed up for at least 12 months postoperatively. The results showed significant improvement in pain scores, disability index, and spinal alignment. The researchers concluded that the "insert and revolve technique" is effective in restoring disc height and spinal alignment with favorable fusion rates. [Extracted from the article]

A recent study conducted by researchers at the University of Uyo in Nigeria has focused on Malnutrition-Related Diabetes Mellitus (MRDM), a rare type of diabetes associated with long-term malnutrition. The study examined the case of a 19-year-old destitute male who presented with symptoms such as abdominal pains, leg swelling, and paresthesia. The patient had been diagnosed with diabetes a year prior but had resorted to herbal remedies due to financial constraints. The researchers concluded that regular screening for MRDM in vulnerable groups is crucial for early detection and treatment. [Extracted from the article]

A patent application has been submitted for an interspinous spacer, a medical device used in spinal surgery. The spacer is designed to alleviate pain caused by spinal stenosis, a condition where the spinal canal narrows and puts pressure on the spinal cord and nerves. It works by opening the spinal canal, maintaining the distance between vertebral body segments, and reducing nerve impingement. The spacer includes an actuator screw, a wedge, and two rotating arms. The patent application also describes different configurations and features of the spacer, as well as a kit that includes the spacer, a spacer insertion instrument, and a driver tool. [Extracted from the article]

The article details a case of a young athlete with both chronic exertional compartment syndrome (CECS) and popliteal artery entrapment syndrome (PAES), highlighting the diagnostic challenges and the need for comprehensive imaging. Topics include the overlapping symptoms of CECS and PAES, the role of dynamic imaging in diagnosis, and the importance of considering multiple diagnoses.

The article discusses a case of refractory chronic leg ulcer treated with percutaneous transluminal angioplasty. Topics include the effectiveness of angioplasty in resolving ultra focal ischemia of the anterior tibial artery, the identification of this artery's stenosis as a primary cause of the leg ulcer, and the overall success of the procedure in achieving wound healing after four months.

The article examines the impact of mind-body cueing in Pilates on managing chronic non-specific low back pain (CNSLBP). It reports that both Pilates interventions showed significant improvements in pain and disability, but Pilates with mind-body cueing offered additional benefits by reducing fear of movement. Topics include the effectiveness of Pilates for CNSLBP, the specific advantages of mind-body cueing, and recommendations for integrating this approach into therapy.

A study conducted by Carolina Neurosurgery and Spine Associates compared the outcomes of two different treatments for lumbar fusion surgery. The study compared the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) with a novel allograft called OSTEOAMP. The results showed that both treatments had similar rates of fusion and improvements in patient-reported outcome measures. The novel allograft was found to be a clinically viable alternative to rhBMP-2, with a comparable safety profile. Further research is needed to explore additional indications and outcomes of the allogeneic graft. [Extracted from the article]

A study published in The Journal of Bone & Joint Surgery has found that Modic changes, which are subchondral changes of the vertebral endplate detected on magnetic resonance imaging, are associated with differences in microbial diversity and metabolites in the lumbar cartilaginous endplates (LCEPs). The researchers suggest that changes in the microbiota may disrupt unsaturated fatty acid metabolism within the LCEP microenvironment, potentially influencing the onset and progression of Modic changes. The study compared the microbiota and metabolic features of LCEPs from spinal fusion patients with and without Modic changes and identified potential biomarkers for Modic changes. The findings may have implications for the diagnosis and treatment of Modic changes. [Extracted from the article]

The article reports on a study comparing minimally invasive transforaminal lumbar interbody fusion (MIS TLIF) to modified open TLIF in treating degenerative lumbosacral spine diseases. Topics discussed include perioperative outcomes like blood loss and radiation dose, post-operative complications such as radiculitis and fixation material malposition, and long-term patient satisfaction and fusion rates.