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The article discusses a systematic review of treatment strategies for erosive genital lichen planus (EGLP), a severe form of lichen planus that causes painful erosions in the genital area. The review emphasizes the importance of patient-centered care and highlights various treatment options such as topical corticosteroids, systemic medications, and surgical interventions. While current therapies are available, some cases of EGLP are refractory to treatment, leading to chronic symptoms and reduced quality of life. The research suggests that a tailored, multidimensional approach is necessary for managing EGLP, with a focus on developing new therapies to improve outcomes and enhance patient care. [Extracted from the article]

Researchers at Bogomolets National Medical University have reported new data on oral lichen planus, a condition with potential risks of malignancy. The study aimed to identify a genetic predisposition to oral lichen planus by analyzing blood groups in patients. The research found correlations between specific blood groups and the development of erosive and hyperkeratotic forms of lichen planus, suggesting a potential link between genetic factors and the disease. [Extracted from the article]

Researchers at the Medical University of Plovdiv conducted a study on oral lichen planus (OLP), a mucocutaneous disease that causes lesions in the mouth. They found that photobiomodulation therapy with a diode laser significantly reduced pain levels and clinical scores of OLP lesions. The therapy also led to a decrease in pro-inflammatory cytokine levels and histological improvements in 60% of patients. This research highlights the effectiveness of photobiomodulation therapy in treating OLP at clinical, molecular, and histomorphological levels. [Extracted from the article]

A recent study from Central Michigan University examined the impact of Lichen Planopilaris (LPP) and its variants, such as frontal fibrosing alopecia (FFA), on individuals' quality of life and mental health. The research found that these conditions can lead to significant psychological distress, impaired quality of life, and higher levels of anxiety and depression. The study emphasizes the importance of early diagnosis and treatment for patients with LPP and FFA to mitigate the negative impact on their mental well-being. For more information, readers can refer to the article "Quality-of-life Assessment and the Impact of Early Diagnosis and Treatment In Lichen Planopilaris: a Systematic Review" published in Clinical and Experimental Dermatology. [Extracted from the article]

A report from University College London (UCL) investigates the impact of oral lichen planus (OLP) on the prognosis of oral epithelial dysplasia (OED). The study found that patients with OLP had a twofold increased risk of developing new primary OED events compared to those without OLP. However, there was no significant difference in progression to malignancy or mortality between the two groups. Further research is needed to understand the effects of OLP on progression to oral squamous cell carcinoma (OSCC) and mortality. [Extracted from the article]

Researchers from Shanghai Jiao Tong University conducted a study on oral lichen planus (OLP) patients to analyze the bacterial communities in their oral mucosa and saliva. The study found differences in the composition, genera associated with OLP severity, and co-occurrence patterns of bacterial communities between OLP patients and healthy controls. The research, supported by the National Natural Science Foundation of China, concluded that the microbial diversity was similar between OLP patients and healthy controls, but the topological properties of the microbial networks differed. This peer-reviewed study provides valuable insights into the oral health of OLP patients. [Extracted from the article]

A recent study conducted by researchers at Queen Mary University of London focused on erosive lichen planus (ELP) and its impact on different ethnicities. The study found that ELP takes longer to diagnose, requires prolonged tertiary care, and is more resistant to treatment compared to milder forms of lichen planus. Patients with ELP have increased medical and oral health needs, are at greater risk of scarring, and may require systemic immunosuppression. The research highlights the importance of educating primary caregivers on ELP's presentation and understanding the mechanisms driving the disease for improved diagnostics and treatment. [Extracted from the article]

A recent study conducted at Islamic Azad University focused on the role of circRNAs in oral cancer, specifically investigating circ-0008798 and circ-0035967 as potential biomarkers in oral lichen planus and oral squamous cell carcinoma. The research found significant upregulation of the MAP2K1 gene in oral cancer tissues, while circ-0008798 and circ-0035967 were down-regulated. The study suggests that these circRNAs could serve as promising biomarkers for the development and progression of oral cancer. For more information, readers can refer to the article "CIRC-0008798 and CIRC-0035967 as novel biomarkers in oral lichen planus and oral squamous cell carcinoma" in Acta Scientiarum. Health Sciences. [Extracted from the article]

A recent study conducted at the Affiliated Stomatological Hospital of Nanjing Medical University in China explored the expression of neutrophil extracellular trap-related proteins in patients with oral lichen planus (OLP) and their correlation with interleukin-17 (IL-17) and tumor necrosis factor a (TNF-a). The research found that OLP patients had elevated levels of NET-related proteins in lesion tissues and peripheral blood, with higher rates of NET formation in erosive-stage OLP compared to non-erosive OLP and healthy controls. The study suggests that IL-17 and TNF-a may play a role in mediating the formation of NETs in OLP patients, potentially contributing to the development of the condition. [Extracted from the article]

A recent study conducted at Sharad Pawar Dental College in Maharashtra, India, focuses on oral lichen planus (OLP), a chronic mucocutaneous immune-mediated disease classified as a Potentially Malignant Disorder (PMD). The research aims to evaluate and compare serum concentrations of Interleukin-1 beta (IL-1b) and Vitamin D in patients with OLP and healthy subjects. The study will be conducted from August 2024 to August 2026, with patients undergoing clinical examinations and providing written consent for sample collection and analysis. Statistical analysis will be performed to assess the significance of the findings. [Extracted from the article]

A recent study from the University of Aberdeen focused on disease severity scoring systems in mucosal lichen planus, a skin condition. The researchers identified 11 clinical severity scoring systems for oral lichen planus that have undergone validity or reliability testing, with the most reported systems being the Thongprasom score, the Oral Disease Severity Score (ODSS), and the REU scoring systems. The study highlighted the need for the development and validation of scoring systems for extraoral mucosal lichen planus. The research was supported by the University of Aberdeen Elphinstone Scholarship Scheme and has been peer-reviewed. [Extracted from the article]

A study conducted at Shanghai Jiao Tong University examined the presence of innate lymphoid cells (ILCs) in oral mucosa of individuals with oral lichen planus (OLP) and oral lichenoid lesions (OLL). The research found increased infiltration of ILCs, specifically ILC1 and ILC3, in OLP and OLL mucosa, while the ratio of ILC2/ILCs was reduced. These changes in ILC distribution may contribute to persistent inflammation in local tissues. The study was supported by various research grants and has been peer-reviewed. [Extracted from the article]

Researchers from Sichuan University in the People's Republic of China have developed an improved scoring system, called the RHU scoring system, for monitoring Oral Lichen Planus (OLP) in patients. This new system considers reticulation, hyperemia, and ulceration to provide a more accurate assessment of OLP severity. The research, funded by various organizations, concluded that the RHU scoring system could be widely used to monitor OLP patients effectively. The study, which has been peer-reviewed, was published in Oral Diseases and can be accessed online for further information. [Extracted from the article]

A recent study conducted at the University of Turin in Italy focused on assessing gingival lesions in 1319 patients with Lichen Planus, a chronic immune disease. The study found that while most patients had multiple oral sites affected, gingival lesions were the sole location in some cases. Only a small percentage of patients experienced total clinical signs remission, and gum lesions appeared to precede oral lesions. Patients with less frequent dental check-ups were more likely to receive specific therapy for Lichen Planus. [Extracted from the article]

A study published in Dermatology Reports discusses Lichen Planus Pigmentosus Inversus (LPPI), a rare variant of lichen planus characterized by dark-gray plaques in intertriginous zones. The study presented a case of a 52-year-old male with LPPI and highlighted the use of topical tacrolimus for treatment. The research found that topical corticosteroids and tacrolimus were the most commonly used therapeutic agents for LPPI. For more information, readers can access the full article through Dermatology Reports. [Extracted from the article]

A recent study conducted at Southern Medical University focused on oral lichen planus, a condition affecting the mucosal lining of the mouth. The research examined the role of mucosal-associated invariant T (MAIT) cells in both recent-onset and long-term cases of oral lichen planus. Findings indicated that MAIT cells in patients with oral lichen planus displayed activation and exhaustion, with differences observed between recent-onset and long-term cases. This study sheds light on the immunological background of oral lichen planus and highlights potential differences in MAIT cell function based on disease duration. [Extracted from the article]

Researchers at Tehran University of Medical Sciences conducted a systematic review and meta-analysis on the identification of common salivary microRNAs in oral lichen planus (OLP) and oral squamous cell carcinoma. The study aimed to find non-invasive diagnostic biomarkers for OLP, which is associated with an increased risk of malignant transformation. Salivary microRNAs showed promising results with high sensitivity and specificity for OLP diagnosis, highlighting their potential as valuable biomarkers in differentiating OLP patients from healthy controls and assessing the risk of malignant transformation. The findings were published in BMC Oral Health and can be accessed for further information. [Extracted from the article]

A recent study conducted by researchers at Carol Davila University of Medicine and Pharmacy in Bucharest, Romania, explores the topic of oral lichen planus (OLP), a complex condition with various clinical manifestations. The study focuses on familial cases of OLP, where the condition appears among members of the same family. The researchers found that genetic factors may play a role in the development of OLP, and they present the clinical characteristics and treatment response of eight cases from four different families. The study highlights the need for further research to better understand the specific manifestation patterns and treatment response of familial OLP cases, as well as the potential for malignant transformation. [Extracted from the article]

A recent study conducted by researchers at Sankalchand Patel University in Gujarat, India, explored the relationship between psychological stress and the severity of oral lichen planus (OLP), oral submucous fibrosis (OSMF), and leukoplakia. The study involved 280 patients aged 35-60, who were divided into four groups: leukoplakia, OSMF, OLP, and a control group. The researchers found that OLP patients had higher levels of serum cortisol, indicating higher levels of stress, anxiety, and depression compared to patients with OSMF and leukoplakia. The study highlights the role of stress and anxiety as predisposing factors in the occurrence and progression of OSMF and OLP. [Extracted from the article]

A recent study conducted by researchers from the University of Bari Aldo Moro in Italy explores the connection between autoimmune thyroid diseases and various autoimmune skin conditions, such as psoriasis, lichen planus, vitiligo, atopic dermatitis, and alopecia areata. The study reveals that these skin disorders are influenced by a combination of genetic predisposition, external factors, and immunological dysfunction. Common pathogenic mechanisms, including disrupted immune tolerance and oxidative stress, contribute to chronic inflammation. The research emphasizes the need for comprehensive diagnosis and treatment, as well as further investigation into specific immunological pathways and biomarkers. [Extracted from the article]

Researchers at the University of Wuerzburg have conducted a study on oral lichen planus, a chronic autoimmune disease that affects the oral mucosa and is considered a potentially malignant disorder. The study aimed to examine the presence of cancer stem cells (CSCs) bearing the marker CD147 in oral lichen planus compared to oral leukoplakia and healthy tissues. The researchers found that CD147 expression was significantly higher in the erosive lichen planus subgroup compared to the dysplastic leukoplakia subgroup, suggesting the presence of epithelial cells with CSC characteristics. However, CD147 expression was lower in oral leukoplakias, indicating a stronger association with inflammation rather than dysplastic progression. [Extracted from the article]

A recent report from Shanghai Jiao Tong University School of Medicine discusses the potential therapeutic efficacy of tinidazole mouth rinse for the treatment of oral lichen planus (OLP). The study involved a pilot study with 27 OLP patients who used thrice-daily tinidazole mouth rinse for one week. The results showed a significant decrease in visual analog scale (VAS) scores for both reticular and erosive OLP patients, as well as a decrease in the abundance of Fusobacterium nucleatum on the damaged mucosa surface. The researchers concluded that tinidazole mouth rinse could be a viable local therapeutic option for OLP, but further randomized controlled studies are needed to confirm these findings. [Extracted from the article]

A recent report from Mahidol University discusses the potential link between embedded earrings and erosive lichen planus, a rare skin condition. The researchers found that removing the earring from the earlobe successfully treated the oral lichen planus in their patient. This concurrent presentation of the two conditions has not been previously described in the literature. The researchers hypothesize that prolonged embedded earrings may be a possible factor in inducing erosive lichen planus. For more information, readers can refer to the article published in Clinical Case Reports. [Extracted from the article]

A recent study conducted by researchers at Sun Yat-sen University explores the role of pyroptosis, a type of cell death, in the development of oral lichen planus (OLP), a chronic inflammatory disease associated with an increased risk of carcinogenesis. The study found that pyroptosis occurs in the epithelial cells of OLP and leads to the secretion of inflammatory factors that activate T cells. This activation is mediated by the expression of optic atrophy 1 (OPA1), which promotes mitochondrial fusion and increases energy metabolism in T cells. These findings provide new insights into the mechanisms and potential therapeutic strategies for OLP. [Extracted from the article]

A recent study conducted by researchers at Hunan University of Chinese Medicine compared the scientometric characteristics of lichen planus (LP) publications in stomatology and dermatology journals. The study found that among the 5,633 papers on LP, 23.9% were published in stomatology journals and 44.9% were published in dermatology journals. The most-cited papers were predominantly published in stomatology journals, and the distinctive keywords in stomatology publications included malignant transformation, genetics, gene expression, and saliva, while dermatology publications focused on hyperkeratosis, hyperpigmentation, and drug research. The researchers hope that these findings will promote mutual understanding and cooperation between stomatology and dermatology in the study of LP. [Extracted from the article]

Researchers from the Hospital of Santa Maria in Lisbon, Portugal have released a new study on alopecia, specifically focusing on central centrifugal cicatricial alopecia (CCCA). This type of alopecia primarily affects middle-aged women of African descent and is characterized by lymphocytic scarring. The study explores the epidemiology, pathogenesis, clinical presentation, trichoscopy, histology, and management of CCCA, highlighting the similarities and differences between CCCA and lichen planopilaris. The researchers emphasize that despite its prevalence and impact, CCCA remains underdiagnosed and understudied. [Extracted from the article]

A recent study conducted at the University Hospital Zurich in Switzerland has examined the differences in gene expression and cellular composition across different subtypes of lichen planus (LP), an inflammatory skin disease. The study found unique inflammatory signatures for each subtype, with lichen planopilaris showing the most divergence. Oral and genital LP demonstrated similar profiles, while classical LP showed strong upregulation of interferon gene signatures. The findings highlight the need for tailored therapeutic approaches for each subtype of LP. The study was supported by the Swisslife Foundation and was published in the International Journal of Molecular Sciences. [Extracted from the article]

A new report from Sichuan University in China explores the potential association between Oral Lichen Planus (OLP) and Candida albicans infection. The study conducted a meta-analysis of individual case-control studies and found a significantly higher detection rate of Candida albicans in OLP patients compared to healthy controls. The research suggests a complex interplay between OLP and Candida albicans, highlighting the need for further research to understand the varying susceptibilities among different clinical types of OLP. This study provides insights for future research directions and clinical treatment strategies in this field. [Extracted from the article]

A new report from Beni Suef University in Egypt presents fresh data on Lichen Planus, a chronic inflammatory autoimmune disease that affects the skin, oral mucosa, and genital mucosa. The study aimed to investigate the role of Elafin, an epithelial host-defense protein, in the pathogenesis of Lichen Planus. The study found that the serum level of Elafin was significantly higher in Lichen Planus patients compared to healthy controls, suggesting that Elafin may be part of the inflammatory autoimmune process in Lichen Planus. This research has been peer-reviewed and provides valuable insights into the understanding of Lichen Planus. [Extracted from the article]

A recent study conducted by the University of Oviedo in Spain explored the potential association between vitamin D deficiency and oral lichen planus (OLP), a condition characterized by inflammation in the mouth. The study found that 45% of OLP patients had vitamin D deficiency, compared to 26.7% in the control group. Additionally, the study revealed that OLP patients who were taking vitamin D supplements had a higher prevalence of the condition. These findings suggest that further research should be conducted to investigate the potential benefits of vitamin D supplementation in managing OLP. [Extracted from the article]

A recent study conducted by researchers at the Medical College of Rzeszow University in Poland focused on pruritus, or itching, in patients with lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA). The study analyzed 61 patients with scarring alopecia and found that itching of the scalp was a common symptom, occurring in 73.8% of the patients. The severity of pruritus was found to be related to certain dermoscopic features such as perifollicular scaling, hair diameter diversity, and white halo. The researchers concluded that a better understanding of pruritic features could aid in the development of effective therapeutic strategies for LPP and FFA. [Extracted from the article]

The article reports on a systematic review and meta-analysis conducted by the University of Barcelona, examining the relationship between oral lichen planus (OLP) and cardiovascular disease (CVD) of atherosclerotic origin. Topics include the lack of evidence for a direct association between OLP and CVD, the observed association between OLP and cardiovascular risk factors, particularly dyslipidemia, and the need for further research to clarify these relationships.

A recent study conducted by researchers at the University of Granada in Spain examined the molecular mechanisms involved in the malignant transformation of oral lichen planus (OLP), a potentially malignant disorder. The study analyzed 110 primary-level studies with 7,065 OLP samples and found that OLP samples exhibited sustained cell proliferation signaling, anti-apoptotic pathways, genome instability, and tumor-promoting inflammation events. However, OLP samples also showed tumor growth suppressor mechanisms, suggesting that malignant transformation may be prevented by tumor suppressor genes. The study suggests that chronic inflammatory infiltrate may contribute to these molecular events. [Extracted from the article]

A recent study conducted at Nanjing University in China analyzed the clinical and pathological characteristics of oral lichen planus (OLP) in 105 Chinese patients. The study found that OLP was most likely to occur in the cheek, followed by the tongue, lips, gums, and palate. The majority of patients experienced moderate pain, and 39% had a systemic disease. Pathological analysis revealed liquefaction degeneration of basal cells and infiltration of lamina propria lymphocytes. The study suggests that further research is needed to understand the specific manifestations and underlying mechanisms of OLP in different patient populations. [Extracted from the article]

A recent report from Alanya Alaaddin Keykubat University discusses new research on oral lichen planus (OLP), a chronic oral mucosal disease of unknown cause. The study aimed to investigate the role of Biglycan (BGN) in Toll-like receptors (TLR)2/4-CD14 and TLR4-CD44 mediated signaling mechanisms in the pathogenesis of OLP. The findings showed that the gene expression of BGN, TLR2, TLR4, and CD14 was higher in OLP tissues compared to the control group, indicating activation of inflammation signaling and inhibition of autophagy in OLP. This study provides new insights into the mechanisms underlying OLP and highlights potential targets for future therapeutic interventions. [Extracted from the article]

A recent study conducted at Coimbra University Hospital in Portugal has provided new data on a dermatosis called Keratosis lichenoides chronica (KLC). KLC is a rare skin condition that was previously thought to be a variant of other inflammatory dermatoses but is now recognized as a distinct condition. The study described the clinical aspects of KLC, including the characteristic lichenoid hyperkeratotic papules and seborrheic-like dermatitis. The patient in the case study was treated with acitretin, topical steroids, and topical calcineurin inhibitors, resulting in partial improvement of the lesions. Further research is needed to understand the underlying mechanisms of KLC. [Extracted from the article]

A new report from the Department of Dermatology in Karnataka, India, discusses the use of patch testing with an Indian standard series of 20 allergens in 125 patients with chronic dermatitis and dermatoses. The study aimed to identify sensitizers and potential causes of chronic, recurring dermatitis and overlap of dermatoses. The patch testing revealed positive results in 81.6% of patients, with nickel, parthenium, cobalt, fragrance, paraphenylenediamine, paraben, and neomycin being the most common allergens. The researchers concluded that patch testing should be considered in patients with chronic and recurrent dermatitis to identify and eliminate culprit allergens for long-term remission. [Extracted from the article]

A report from researchers at the University of Sao Paulo discusses the occurrence of squamous cell carcinoma (SCC) in various oral mucosal diseases, including oral lichen planus, dyskeratosis congenita, tertiary syphilitic glossitis, chronic graft-versus-host disease, and oral discoid lupus erythematosus. The researchers suggest that these diseases are not "pre-malignant," but rather their long-lasting mucosal scars are prone to the development of SCC. They propose that SCC in these diseases can be considered a mucosal type of Marjolin ulcer. The report provides new insights into the understanding of these diseases and their potential for malignancy. [Extracted from the article]

A recent study conducted by researchers at Wroclaw Medical University in Poland aimed to assess the levels of salivary histamine in patients with oral lichen planus (OLP) lesions. The study included 76 patients with OLP, and the results showed that the histamine levels in the OLP group were higher compared to the control group, although the difference was not statistically significant. The study also evaluated other factors such as general diseases, medication, smoking habits, pain severity, oral hygiene, and duration of OLP. The researchers concluded that further research is needed to explore general factors in the development of OLP. [Extracted from the article]

A recent study conducted by the Medical University of Warsaw aimed to improve the diagnostic accuracy of oral lichen planus (OLP), a condition with nonspecific symptoms and histopathological features. The researchers developed a multivariate predictive model based on an Artificial Neural Network, integrating direct immunofluorescence (DIF) results and clinical data. The model achieved 85% accuracy in the testing sample and 71% accuracy in the validation sample. However, the researchers noted that larger datasets and more comprehensive variables are needed to further improve diagnostic accuracy for OLP, emphasizing the need for additional research and collaborative data collection efforts. [Extracted from the article]

A recent report from Southern Medical University discusses the role of mucosal-associated invariant T (MAIT) cells in oral lichen planus (OLP), an autoimmune inflammatory condition. The study examined the frequency, phenotype, and functions of MAIT cells in patients with non-erosive OLP, erosive OLP, and healthy adults. The findings revealed that MAIT cells in non-erosive OLP patients displayed an activated phenotype, while erosive OLP patients showed an activation and depletion phenotype. Additionally, MAIT cells in erosive OLP patients exhibited heightened cytokine production. The study also found that corticosteroid therapy influenced the expression of certain phenotypes and functions of MAIT cells in OLP patients. Overall, the research suggests that MAIT cells play a role in the pathogenesis of OLP and that corticosteroid therapy can affect their behavior. [Extracted from the article]

A report from Mayo Clinic in Rochester, Minnesota discusses the diagnosis and treatment of lichen planus (LP), a chronic inflammatory disease that affects approximately 0.5-1% of the population. LP can manifest in various ways, including on the skin, mucous membranes, and appendages. The research highlights the systemic associations of LP, such as autoimmune conditions and cardiovascular disorders, and emphasizes the importance of long-term follow-up and regular screening. The report also mentions recent advancements in targeted treatment options, including Janus kinase inhibitors and biologics. The study concludes by providing an overview of the current understanding of LP and its management. [Extracted from the article]

A report from researchers at Katihar Medical College in Bihar, India discusses the use of guselkumab, an interleukin 23p19 inhibitor, for the treatment of psoriasis. The US Food and Drug Administration has approved guselkumab for the management of moderate to severe psoriasis. The researchers conducted a review of scholarly articles and found that guselkumab has also been effective in treating other dermatologic conditions such as hidradenitis suppurativa, lichen planus, pityriasis rubra pilaris, pyoderma gangrenosum, and Stewart-Treves angiosarcoma. The researchers concluded that guselkumab has a wide range of applications beyond psoriasis and has an acceptable safety profile. [Extracted from the article]

A recent study conducted by researchers from Fayoum University explored the role of vitamin D in the management of oral lichen planus (OLP), an immune-mediated inflammatory disease affecting the skin and oral mucosa. The study found that vitamin D exhibits immune-modulatory, anti-inflammatory, and antimicrobial properties, as well as anti-proliferative, pro-differentiative, and anti-angiogenic effects. The researchers conducted a randomized clinical trial involving 40 OLP patients and found that the addition of vitamin D supplements to systemic steroids resulted in greater pain relief, resolution of clinical lesions, and reduction in the severity of lesions compared to systemic steroids alone. The study suggests that vitamin D may have a preventive and therapeutic role in the treatment of OLP, but further research is needed. [Extracted from the article]

A recent study conducted by the Iranian Center of Neurological Research has reported on the rare co-occurrence of myasthenia gravis (MG) and lichen planus (LP). The study found that there have been only 13 reported cases of this co-occurrence in the English literature between 1971 and 2024. The study highlights the need for close monitoring of patients with MG or LP for other autoimmune diseases. The researchers suggest that a common autoimmune mechanism may underlie the unclear pathophysiology of this co-occurrence. [Extracted from the article]

A meta-analysis conducted by researchers at Poznan University of Medical Sciences in Poland explored the potential association between human papillomavirus (HPV) and oral lichen planus (OLP), a chronic inflammatory disease. The analysis included 13 studies from eight countries and found that HPV infection was associated with a higher risk of developing OLP. The odds ratios ranged from 2.10 to 3.54, depending on the data used. This research provides valuable insights into the potential role of HPV in OLP and may contribute to future studies and treatments. [Extracted from the article]