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A recent study conducted by researchers from Ohio State University explores the use of photodynamic therapy (PDT) as a potential treatment option for two rare genetic skin diseases, Darier disease and Hailey-Hailey disease. These diseases have a negative impact on patients' quality of life and pose challenges for dermatologists. The study found that PDT can induce disease remission for several months or years, but further research is needed to address unanswered questions regarding cost, tolerability, efficacy, safety in patients with darker skin, and treatment recommendations. The research has been peer-reviewed and published in the Archives of Dermatological Research. [Extracted from the article]

A recent study conducted by researchers at the University of Michigan aims to better understand vulvar acantholytic dyskeratoses, a group of skin diseases that rarely affect the vulva and perineum. The study analyzed 16 cases of vulvar acantholytic dyskeratoses diagnosed between 1990 and 2023. The patients, aged 36 to 79, presented with asymptomatic or pruritic lesions on the vulva, predominantly the labia majora. The study found that histological features were not reliable in distinguishing between sporadic and syndromic acantholytic dyskeratoses. Treatment options varied, with sporadic lesions being cured by local excision and patients with Hailey-Hailey disease showing variable responsiveness to corticosteroids. The study also highlighted the importance of considering differential diagnoses such as pemphigus vulgaris and pemphigus vegetans. [Extracted from the article]

The article offers information on recent research from the First Hospital of Jilin University regarding the treatment of Hailey-Hailey disease using biologics and small molecule inhibitors. Topics discussed include the chronic nature and psychological impact of Hailey-Hailey disease; the evaluation of various biologics and inhibitors like dupilumab and adalimumab; and the need for further large-scale trials to confirm the efficacy of these treatments.

A recent study conducted by Tehran University of Medical Sciences in Iran focused on Hailey-Hailey disease (HHD), a rare inherited blistering skin disorder. The study aimed to understand the demographic characteristics and treatment strategies for managing HHD. The research found that there is currently no standard treatment for HHD, but topical steroids and antimicrobial agents are commonly used. The study concluded that HHD poses a significant challenge for dermatologists and often presents a diagnostic challenge. For more information, the full article can be accessed through the provided link. [Extracted from the article]

A recent study conducted at Obafemi Awolowo University in Nigeria focused on Hailey-Hailey disease (HHD), a rare autosomal-dominant blistering disorder characterized by macerated velvety, fissured, hypertrophic plaques in the intertriginous areas. The researchers noted that HHD is often misdiagnosed due to its resemblance to other dermatoses in these areas and its rarity. The study presented a case report of two unrelated Nigerians with HHD who were successfully diagnosed and managed at the university's dermatology clinic. This research provides valuable insights into the diagnosis and management of this rare hereditary disease. [Extracted from the article]

A recent study conducted by the Karolinska Institute in Stockholm, Sweden, has found a potential association between Hailey-Hailey disease, a rare hereditary skin disease, and diabetes. The study involved a population-based cohort study, pedigree analysis, and clinical cohort study. The results showed that males with Hailey-Hailey disease had a 70% increased risk of type 2 diabetes, while no excess risk was observed among women. The study suggests that Hailey-Hailey disease may act as a synergistic risk factor for diabetes and provides evidence of a potential link between the disease and diabetes pathophysiology. [Extracted from the article]

Keywords: Maywood; State:Illinois; United States; North and Central America; Acute Generalized Exanthematous Pustulosis; Antibiotics; Antiinfectives; Benign Familial Pemphigus; Clindamycin Therapy; Dermatological Agents; Drugs and Therapies; Genetic Diseases and Conditions; Hailey-Hailey Disease; Health and Medicine; Lincomycin Derivatives; Pharmaceuticals; Psoriasis; Skin Diseases and Conditions; Skin and Connective Tissue Diseases and Conditions; Topical Acne Agents EN Maywood State:Illinois United States North and Central America Acute Generalized Exanthematous Pustulosis Antibiotics Antiinfectives Benign Familial Pemphigus Clindamycin Therapy Dermatological Agents Drugs and Therapies Genetic Diseases and Conditions Hailey-Hailey Disease Health and Medicine Lincomycin Derivatives Pharmaceuticals Psoriasis Skin Diseases and Conditions Skin and Connective Tissue Diseases and Conditions Topical Acne Agents 1138 1138 1 08/14/23 20230818 NES 230818 2023 AUG 18 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Research findings on Skin Diseases and Conditions - Acute Generalized Exanthematous Pustulosis are discussed in a new report. According to the news reporters, the research concluded: "Early diagnosis of AGEP is essential to initiate prompt and aggressive systemic therapy, prompt medication cessation, close monitoring for end-organ damage, and improve overall morbidity and mortality.". [Extracted from the article]

Benign Familial Pemphigus, Carbon Dioxide, Chemicals, Genetic Diseases and Conditions, Hailey-Hailey Disease, Health and Medicine, Risk and Prevention, Skin Diseases and Conditions Keywords: Benign Familial Pemphigus; Carbon Dioxide; Chemicals; Genetic Diseases and Conditions; Hailey-Hailey Disease; Health and Medicine; Risk and Prevention; Skin Diseases and Conditions EN Benign Familial Pemphigus Carbon Dioxide Chemicals Genetic Diseases and Conditions Hailey-Hailey Disease Health and Medicine Risk and Prevention Skin Diseases and Conditions 705 705 1 05/08/23 20230512 NES 230512 2023 MAY 12 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators publish new report on benign familial pemphigus. [Extracted from the article]

It is caused by a mutation in the gene that codes for a specific protein involved in the transportation of calcium and manganese ions from the cell cytoplasm and into a sac-like organelle called the Golgi apparatus. Keywords: Benign Familial Pemphigus; Genetic Diseases and Conditions; Hailey-Hailey Disease; Health and Medicine; Heavy Metals; Manganese; Skin Diseases and Conditions; Tohoku University EN Benign Familial Pemphigus Genetic Diseases and Conditions Hailey-Hailey Disease Health and Medicine Heavy Metals Manganese Skin Diseases and Conditions Tohoku University 242 242 1 04/10/23 20230414 NES 230414 2023 APR 14 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Hailey-Hailey disease is a rare, inherited condition characterized by patches of blisters appearing mainly in the skin folds of the arm pits, groin and under the breasts. Calcium ions are vital for cell signalling processes and are important for proteins to function properly, so maintaining the right calcium ion balance inside cells is necessary for their day-to-day activities. [Extracted from the article]

Keywords: Tokyo; Japan; Asia; Benign Familial Pemphigus; Genetic Diseases and Conditions; Genetics; Hailey-Hailey Disease; Health and Medicine; Pediatrics; Skin Diseases and Conditions EN Tokyo Japan Asia Benign Familial Pemphigus Genetic Diseases and Conditions Genetics Hailey-Hailey Disease Health and Medicine Pediatrics Skin Diseases and Conditions 256 256 1 04/03/23 20230407 NES 230407 2023 APR 8 (NewsRx) -- By a News Reporter-Staff News Editor at Pediatrics Week -- New research on Skin Diseases and Conditions - Benign Familial Pemphigus is the subject of a report. Tokyo, Japan, Asia, Benign Familial Pemphigus, Genetic Diseases and Conditions, Genetics, Hailey-Hailey Disease, Health and Medicine, Pediatrics, Skin Diseases and Conditions Keywords for this news article include: Asia, Tokyo, Japan, Pediatrics, Health and Medicine, Hailey-Hailey Disease, Benign Familial Pemphigus, Skin Diseases and Conditions, Genetic Diseases and Conditions. [Extracted from the article]