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A study conducted by researchers at Damascus University aimed to investigate the prevalence and frequency of three germ-line founder mutations in the BRCA1/2 genes among early-onset breast cancer patients in Syria. The study found that these mutations were not common among Syrian female patients with early-onset breast cancer and were not associated with familial breast cancer. The researchers recommend further studies and the implementation of nationwide mutation screening tests for BRCA1/BRCA2 in the Syrian population. The study provides insights into the genetic factors contributing to breast cancer in Syria and highlights the importance of genetic counseling and risk assessment in the development of effective screening strategies. [Extracted from the article]