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Researchers at Wuhan Asia Heart Hospital conducted a study to determine if patients with atrial fibrillation (AF) and patent foramen ovale (PFO) were at an increased risk of stroke. The study found that the presence of PFO did not increase the risk of stroke in AF patients who underwent left atrial appendage closure (LAAC). The research concluded that AF patients with PFO are not at a higher risk for ischemic stroke or transient ischemic attack (TIA) before LAAC, and that major leakage (>5 mm) was associated with a higher risk of stroke events in these patients. [Extracted from the article]

The article discusses the impact of percutaneous atrial septal occluder (ASO) devices on left atrial (LA) function in patients with cryptogenic stroke (CS) undergoing closure of patent foramen ovale (PFO). The study found that PFO device closure negatively affects LA function, leading to increased atrial volumes, worsening left ventricular diastolic function, and decreased reservoir and conduit function. While some normalization is observed at 18 months follow-up, baseline parameters are not fully reached. This research highlights the importance of monitoring long-term effects of PFO closure on LA function in patients with CS. [Extracted from the article]

Researchers at Federico II University Hospital have published a study on the possible association between patent foramen ovale (PFO) and strokes. The study describes a case of a 52-year-old man with PFO who experienced deep vein thrombosis and subsequent ischemic strokes despite treatment. The research suggests that the presence of PFO may be linked to cerebral ischemic events and highlights the association with deep vein thrombosis. [Extracted from the article]

Researchers at the Department of Cardiovascular Diseases conducted a retrospective analysis of 62 patients who underwent percutaneous closure of patent foramen ovale (PFO) or atrial septal defect (ASD) at Mayo Clinic, Arizona. They found that 12.9% of patients developed fever following the procedure, with a higher incidence of self-limited atrial fibrillation in these cases. The fever was benign and self-limiting, with no evidence of infection found, but further investigation is needed to determine its true incidence, mechanism, and prognosis. [Extracted from the article]

This document provides information about a clinical trial study on stroke prevention. The study aims to improve adherence to best practice recommendations for secondary stroke prevention in patients with ischemic stroke or TIA. The intervention arm of the study will receive an educational and implementation Neurocardiology tool, while the comparator arm will not receive any intervention until the follow-up period is completed. The study is not yet recruiting and is expected to enroll 2400 participants, with a completion date of December 2025. The study is being conducted in Canada and is sponsored by the Lawson Health Research Institute. [Extracted from the article]

A new report from the University of Cagliari discusses research findings on patent foramen ovale (PFO), a congenital heart anomaly characterized by a persistent opening between the atrial septum. While PFO is often asymptomatic, it can lead to various clinical presentations, including cryptogenic stroke and other embolic events. The report emphasizes the importance of a multidisciplinary approach involving ophthalmologists, cardiologists, neurologists, and imaging specialists in the diagnosis and treatment of PFO-related ocular complications. The researchers call for further studies and clinical trials to provide insights into preventive measures and optimal therapeutic strategies for managing PFO-related ocular complications. [Extracted from the article]

A study conducted at the Karolinska Institute in Stockholm, Sweden, examined the feasibility of same-day discharge (SDD) after percutaneous closure of persistent foramen ovale (PFO) using intracardiac echocardiography and the Gore Septal Occluder. The study included 262 patients who underwent PFO closure, with 94% of them being discharged on the same day. The overall closure rate at follow-up was 98.5%, and the rates of complications and readmissions were low. The researchers concluded that SDD after transcatheter PFO closure with the Gore Septal Occluder is a safe and cost-effective option. [Extracted from the article]

This article discusses the quantification of patent foramen ovale (PFO) shunt severity using transesophageal echocardiogram (TEE) and transcranial Doppler (TCD) in routine clinical practice. The study found that formal, evidence-based ratings of PFO shunt severity were present in less than 1 out of every 6 TEE reports, and informal size estimates correlated poorly with TCD quantification of shunt severity. The researchers suggest that including formal PFO shunt size quantification in all clinical stroke patient TEE reports would aid in patient management. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]

This article discusses the clinical implications and procedural complications in patients with patent foramen ovale (PFO) concomitant with atrial septal aneurysm (ASA). ASA is defined as the excursion of the atrial septum exceeding a certain measurement, and previous studies have shown that 20-40% of PFO cases are accompanied by ASA. The presence of ASA is associated with various conditions such as left atrial dysfunction, cryptogenic stroke, migraine, and arterial embolism, making the closure of PFO in patients with concomitant ASA necessary but challenging. The article reviews the clinical implications, complications, and provides practical guidance for the closure procedure of concomitant PFO and ASA. [Extracted from the article]

The US Patent and Trademark Office has published a patent application for a closure system designed to close holes or ducts in heart tissue. The system, invented by Harutoshi UCHIDA, includes a catheter and a closure device consisting of a resin-containing extension part. The patent application also outlines a manufacturing method that involves using a learning model to design the closure device based on the shape and position of the hole or duct. The closure device may include additional features such as a heart rate sensor or a power generating element. This system aims to address issues associated with existing closure devices and provide an effective solution for closing various types of holes or ducts in the heart. [Extracted from the article]

A new report from the Tzaneio General Hospital of Piraeus presents fresh data on patent foramen ovale (PFO), a condition where a hole in the heart's septum fails to close after birth. The study compares left atrial strain values between patients with ischemic stroke and healthy individuals. The research found that stroke patients had significantly lower left atrial strain values compared to healthy individuals, and within the stroke group, individuals with PFO had higher left atrial strain values compared to those without PFO. This study highlights the importance of left atrial functionality in understanding the pathophysiology of embolic strokes. [Extracted from the article]

A recent study from the University of Bern in Switzerland highlights the importance of addressing patent foramen ovale (PFO), a condition where a hole in the heart's septum fails to close after birth. The researchers argue that PFO poses a serious threat to health and can lead to various complications, including death, stroke, and embolism. They suggest that PFO closure should be used for primary prevention, as it is a simple and effective intervention. Additionally, the study suggests that closing PFOs can also have collateral benefits, such as improving quality of life for patients with conditions like migraine or exercise dyspnea. [Extracted from the article]

A study conducted by researchers at Zhejiang Chinese Medical University in Hangzhou, China, investigated the genetic variants associated with patent foramen ovale (PFO), a condition linked to cardiovascular disorders. The study utilized whole-exome sequencing to analyze mutant genes in 25 PFO patients and identified pathogenic mutations in LDLR, SDHC, and NKX2-5 genes. The findings suggest that these genes play a role in PFO development and provide potential therapeutic targets for future research. The study enhances our understanding of the genetic basis of PFO and its association with cardiovascular disorders. [Extracted from the article]

A recent study conducted at University Hospital in Krakow, Poland explored the relationship between the anatomy of the atrial septum and the risk of ischemic neurological events in patients with a patent foramen ovale (PFO). The study found that factors such as female sex, hypercholesterolemia, the width of the PFO canal, and the size of the right-to-left shunt were significantly associated with stroke and/or transient ischemic attack (TIA). The researchers concluded that the dimensions of the PFO canal and the magnitude of the right-to-left shunt, along with specific demographic and clinical factors, are linked to ischemic neurological incidents in PFO patients. [Extracted from the article]

A recent report from Central South University discusses the findings of a case study on white matter lesions (WMLs) in the brain. WMLs are structural changes that can be caused by demyelination in the central nervous system. The study focused on a 25-year-old male patient who presented with recurrent headaches and was found to have widespread WMLs. Genetic testing revealed a mutation in the SERPINC1 gene, which resulted in antithrombin deficiency and may have contributed to the presence of the WMLs. The patient underwent surgery and reported relief from headaches, although the lesions remained unchanged on MRI. This case study suggests that hereditary antithrombin deficiency could be a potential cause of asymptomatic WMLs. [Extracted from the article]

This document provides information about a clinical trial in China, NCT06347276, which is currently recruiting participants. The trial aims to investigate the occurrence of de novo cerebral microembolization in patients undergoing transcatheter closure of patent foramen ovale (PFO) or atrial septal defect (ASD). The study also aims to evaluate the relationship between de novo cerebral microembolization and in situ thrombus within PFO. The trial is observational in nature and will use diffusion-weighted magnetic resonance imaging to assess cerebral microembolization. The study is open to individuals aged 18 to 65 years of all sexes, and the contact information for the primary investigator is provided for those interested in participating. [Extracted from the article]

A study conducted in Istanbul, Turkey, examined the relationship between patent foramen ovale (PFO) and cryptogenic stroke (CS). The researchers used transesophageal echocardiography (TEE) and contrast transesophageal echocardiography (c-TEE) to evaluate the characteristics of PFO associated with CS and identify high-risk factors for PFO. The study found that the length of the PFO tunnel, low-angle PFO, right-to-left shunt (RLS) grade III during Valsalva, and the presence of atrial septal aneurysm (ASA) were associated with a greater risk of CS. The researchers concluded that TEE combined with c-TEE could be useful in identifying PFO patients at high risk of CS and screening for transcatheter closure of PFO. [Extracted from the article]

A recent study conducted at the University Hospital Center in Portugal examined the safety of same-day discharge (SDD) following percutaneous closure of patent foramen ovale (PFO), a condition associated with stroke and paradoxical embolism. The study included 122 patients who underwent successful elective percutaneous closure without complications, with 40% of them being discharged on the same day. The researchers found that SDD after PFO closure was a safe and successful patient management method. They suggest that in the future, PFO closure may become an ambulatory procedure in selected cases. [Extracted from the article]

A recent report from the Department of Cardiovascular Surgery explores the relationship between patent foramen ovale (PFO) and neurological diseases such as stroke, migraine, obstructive sleep apnea syndrome (OSAS), and decompression sickness (DCS). The researchers suggest that closing PFO could effectively prevent and treat these neurological diseases. The report focuses on the pathogenesis, epidemiology, and clinical characteristics of these diseases, and discusses the potential complexity and future development of PFO closure as a treatment. The aim of the research is to provide guidance for the diagnosis and treatment of neurological diseases related to PFO. [Extracted from the article]

A recent study conducted by Central South University in Hunan, China investigated the association between patent foramen ovale (PFO) and unexplained syncope in pediatric patients. The study included 1001 pediatric patients aged 4 to 17 years who were hospitalized for symptoms such as syncope, palpitation, headache, dizziness, and chest pain. The researchers found that PFO was not significantly associated with an increased risk of syncope in pediatric patients. However, they suggest that further research with a larger sample size is needed to explore this association. [Extracted from the article]

A clinical trial is being conducted in Russia to assess the effectiveness and safety of endovascular closure of patent foramen ovale (PFO) in patients over 18 years old. The trial will involve participants from 29 medical centers in Russia and will focus on the relationship between PFO and cryptogenic stroke, a type of stroke with an unknown cause. The trial will evaluate the success rate of the procedure and the occurrence of any adverse events. The study is expected to be completed by March 2025 and is considered safe for patients. [Extracted from the article]

For more information on this research see: Clinical Outcomes and Quality of Life after Patent Foramen Ovale (PFO) Closure in Patients with Stroke/Transient Ischemic Attack of Undetermined Cause and Other PFO-Associated Clinical Conditions: A Single-Center Experience. Keywords: Cardio Device; Cardiovascular Diseases and Conditions; Central Nervous System Diseases and Conditions; Cerebrovascular Diseases and Conditions; Foramen Ovale; Headache and Migraine; Health and Medicine; Heart Disorders and Diseases; Heart Septum; Magnetic Resonance Imaging; Medical Devices; Nervous System Diseases and Conditions; Neurology; Patent Foramen Ovale; Primary Headache Diseases and Conditions; Quality of Life; Stroke; Transient Ischemic Attack EN Cardio Device Cardiovascular Diseases and Conditions Central Nervous System Diseases and Conditions Cerebrovascular Diseases and Conditions Foramen Ovale Headache and Migraine Health and Medicine Heart Disorders and Diseases Heart Septum Magnetic Resonance Imaging Medical Devices Nervous System Diseases and Conditions Neurology Patent Foramen Ovale Primary Headache Diseases and Conditions Quality of Life Stroke Transient Ischemic Attack 918 918 1 10/09/23 20231013 NES 231013 2023 OCT 9 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Devices & Surgical Technology Week -- A new study on patent foramen ovale is now available. Cardio Device, Cardiovascular Diseases and Conditions, Central Nervous System Diseases and Conditions, Cerebrovascular Diseases and Conditions, Foramen Ovale, Headache and Migraine, Health and Medicine, Heart Disorders and Diseases, Heart Septum, Magnetic Resonance Imaging, Medical Devices, Nervous System Diseases and Conditions, Neurology, Patent Foramen Ovale, Primary Headache Diseases and Conditions, Quality of Life, Stroke, Transient Ischemic Attack. [Extracted from the article]

Keywords: Rovigo; Italy; Europe; Aneurysm; Cardiovascular Diseases and Conditions; Cerebrovascular Diseases and Conditions; Foramen Ovale; Health and Medicine; Heart Disorders and Diseases; Heart Septum; Patent Foramen Ovale; Risk and Prevention; Stroke EN Rovigo Italy Europe Aneurysm Cardiovascular Diseases and Conditions Cerebrovascular Diseases and Conditions Foramen Ovale Health and Medicine Heart Disorders and Diseases Heart Septum Patent Foramen Ovale Risk and Prevention Stroke 428 428 1 10/09/23 20231009 NES 231009 2023 OCT 9 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- Data detailed on Heart Disorders and Diseases - Patent Foramen Ovale have been presented. Rovigo, Italy, Europe, Aneurysm, Cardiovascular Diseases and Conditions, Cerebrovascular Diseases and Conditions, Health and Medicine, Heart Disorders and Diseases, Heart Septum, Patent Foramen Ovale, Foramen Ovale, Risk and Prevention, Stroke. [Extracted from the article]

The patient was treated with open surgical embolectomy for a pulmonary artery thrombus and PFO thrombus with simultaneous closure of the PFO. Keywords: Angiology; Arteries; Blood Vessels; Cardiovascular Diseases and Conditions; Cardiovascular System; Embolism and Thrombosis; Foramen Ovale; Health and Medicine; Heart Disorders and Diseases; Heart Septum; Hematology; Inferior Vena Cava; Patent Foramen Ovale; Pulmonary Artery; Thromboembolism; Thrombosis; Vascular Diseases and Conditions; Vena Cava; Venae Cavae; Venous Thromboembolism EN Angiology Arteries Blood Vessels Cardiovascular Diseases and Conditions Cardiovascular System Embolism and Thrombosis Foramen Ovale Health and Medicine Heart Disorders and Diseases Heart Septum Hematology Inferior Vena Cava Patent Foramen Ovale Pulmonary Artery Thromboembolism Thrombosis Vascular Diseases and Conditions Vena Cava Venae Cavae Venous Thromboembolism 632 632 1 09/25/23 20230929 NES 230929 2023 SEP 25 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- Investigators discuss new findings in patent foramen ovale. [Extracted from the article]

The PFO-AF study (registered with ClinicalTrials.gov under the number NCT04926142) will investigate the incidence of AF occurring within 2 months after percutaneous closure of PFO in patients with prior stroke. According to news originating from Besancon, France, by NewsRx correspondents, research stated, "After closure of patent foramen ovale (PFO) due to stroke, atrial fibrillation (AF) occurs in up to one in five patients. Keywords: Atrial Fibrillation; Cardiac Arrhythmias; Cardio Device; Cerebrovascular Diseases and Conditions; Foramen Ovale; Health and Medicine; Heart Disease; Heart Disorders and Diseases; Heart Septum; Medical Devices; Patent Foramen Ovale; Stroke EN Atrial Fibrillation Cardiac Arrhythmias Cardio Device Cerebrovascular Diseases and Conditions Foramen Ovale Health and Medicine Heart Disease Heart Disorders and Diseases Heart Septum Medical Devices Patent Foramen Ovale Stroke 207 207 1 09/25/23 20230925 NES 230925 2023 SEP 25 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- Researchers detail new data in patent foramen ovale. [Extracted from the article]

Keywords: Cerebrovascular Diseases and Conditions; Foramen Ovale; Health and Medicine; Heart Disorders and Diseases; Heart Septum; Patent Foramen Ovale; Stroke EN Cerebrovascular Diseases and Conditions Foramen Ovale Health and Medicine Heart Disorders and Diseases Heart Septum Patent Foramen Ovale Stroke 581 581 1 03/27/23 20230327 NES 230327 2023 MAR 27 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- Investigators discuss new findings in patent foramen ovale. Cerebrovascular Diseases and Conditions, Foramen Ovale, Health and Medicine, Heart Disorders and Diseases, Heart Septum, Patent Foramen Ovale, Stroke. [Extracted from the article]