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Researchers from the Department of Nephrology have conducted a study on intronic variants of the PKHD1 gene, which is associated with Autosomal Recessive Polycystic Kidney Disease (ARPKD). By analyzing these variants at the mRNA level using minigene-based splice assays, they identified 11 variants that induce splicing alterations, leading to various consequences such as exon skipping, intron retention, and protein truncation. The research highlights the importance of mRNA-level assessment for genetic diagnostics in related disorders, emphasizing the significance of understanding genetic mechanisms in disease pathology. [Extracted from the article]

The patent application by inventor Ravindra Kumar focuses on ActRII antagonists for treating renal diseases like Alport syndrome, focal segmental glomerulosclerosis, polycystic kidney disease, and chronic kidney disease. These ActRII antagonists inhibit TGF-beta family ligands and downstream signaling components to address complications of renal diseases. The methods outlined in the patent application involve administering ActRIIA or ActRIIB variant polypeptides to patients in need, potentially in combination with other therapies like angiotensin receptor blockers or ACE inhibitors. The goal is to reduce the severity, occurrence, and duration of albuminuria stages in patients with renal diseases. [Extracted from the article]

Researchers at the Department of Medical Genetics and Prenatal Diagnosis in Chengdu, China, conducted a study on the genetic variation in two families with autosomal recessive polycystic kidney disease (ARPKD). They identified compound heterozygous mutations in the PKHD1 gene in both families, leading to perinatal stage ARPKD. The study highlights the importance of early genetic counseling and prenatal diagnosis for families affected by ARPKD. For more information, the full article can be accessed for free at https://doi.org/10.3969/j.issn.1671-2390.2024.10.002. [Extracted from the article]

The article from Women's Health Weekly discusses research on oligohydramnios, a condition characterized by low levels of amniotic fluid during pregnancy. The study highlights the challenges in diagnosing and predicting outcomes for fetuses with echogenic kidneys and oligohydramnios. It emphasizes the importance of accurate diagnosis, molecular testing, and postnatal renal pathology for effective counseling and management. The research was conducted by the Division of Medical Genetics and funded by Mahidol University, with findings published in BMC Pregnancy and Childbirth. [Extracted from the article]

A recent report from Johns Hopkins University explores diseases related to dysfunction of primary cilia, such as polycystic kidney diseases and multisystem ciliopathies. These disorders can lead to kidney dysfunction, hepatic fibrosis, retinal dystrophy, obesity, and other manifestations. Over 190 genes associated with primary cilia have been identified as disease-causing, highlighting the complexity of these conditions. The research aims to provide a comprehensive review of the clinical characteristics of primary cilia disorders. [Extracted from the article]

According to a preprint abstract, researchers investigated the role of the Hedgehog (Hh) pathway in Autosomal Recessive Polycystic Kidney Disease (ARPKD). They found elevated levels of the Hh transcriptional effector Gli3 in a mouse model of ARPKD and in a human cellular ARPKD model. However, reducing Gli3 levels did not affect cyst formation in the mouse model or cyst size in the human cellular model. These findings suggest that elevated Gli3 does not modulate cyst progression in ARPKD, highlighting the complexity of the Hh pathway in Polycystic Kidney Disease. [Extracted from the article]

A clinical trial has been launched at Sohag University Hospital to study congenital hepatic fibrosis and autosomal recessive polycystic kidney disease in children. Polycystic kidney disease is a hereditary disorder characterized by the formation of fluid-filled cysts in the kidneys, which can lead to renal impairment. The trial aims to investigate the incidence of congenital hepatic fibrosis in patients with autosomal recessive polycystic kidney disease and explore its clinical manifestations, diagnosis, management, and complications. The trial is currently recruiting pediatric patients aged 0-18 years in Egypt. [Extracted from the article]

Researchers at Tokyo Women's Medical University have published a case report on polycystic kidney disease (PKD). The study focused on a child with very early-onset PKD and a history of large, echogenic kidneys in utero. Genetic analysis revealed compound heterozygous variants in the PKD1 gene, which were likely pathogenic. Pathological examination of the patient's kidney showed pronounced elongation of the primary cilia, suggesting that the hypomorphic PKD1 variants expressed in this patient were pathogenic. This research provides valuable insights into the pathology of PKD. [Extracted from the article]

This article discusses the use of patient-derived human organoids to study the physiological functions of the human stomach. The researchers found that region-specific gastric organoids can self-assemble into complex multi-regional structures called assembloids, which exhibit functional responses to drugs targeting the ATPase H+/K+ pump. These assembloids preserve the regional identity of the stomach and allow for the emergence of parietal cells, which produce gastric acid. The researchers also generated assembloids from patients with a genetic condition associated with antral foveolar hyperplasia and hyperplastic polyposis, providing a model to study these phenomena. Overall, this research offers a promising tool for studying gastric epithelial interactions and disease mechanisms. [Extracted from the article]

The article discusses a clinical trial, NCT06499948, that is investigating the use of Dapagliflozin, Spironolactone, and their combination in adult patients with Alport syndrome (AS). AS is a kidney disorder caused by genetic variants, and there is currently no specific treatment for it. The trial aims to evaluate if these drugs, in combination with renin-angiotensin-system inhibitors, can slow the progression of chronic kidney disease. The primary outcome of the trial is the effect on albuminuria, a marker for kidney disease progression. The trial is currently recruiting participants and is expected to be completed by December 2025. [Extracted from the article]

A recent study conducted by Kuwait University explored the genetic landscape and clinical outcomes of autosomal recessive polycystic kidney disease (ARPKD) in Kuwait. The study recruited 60 individuals with suspected ARPKD from diverse ethnic backgrounds and collected comprehensive clinical data. The results showed that ARPKD exhibited diverse clinical features, including systematic hypertension, pulmonary hypoplasia, dysmorphic features, cardiac problems, cystic liver, Potter syndrome, developmental delay, and enlarged cystic kidneys. Mutations were identified in various genes, with the majority found in the PKHD1 gene. The study emphasizes the need for personalized approaches to improve ARPKD diagnosis and treatment. [Extracted from the article]

A study conducted by Nanjing Medical University in Shanghai, China, explores the role of polycystic kidney and hepatic disease 1-like 1 (PKHD1L1) in lung adenocarcinoma (LUAD). The study found that PKHD1L1 is downregulated in LUAD and predicts poor outcomes for patients. Upregulation of PKHD1L1 inhibits the proliferative, invasive, and migrative capabilities of LUAD cells and increases the apoptotic rate. The study also suggests that PKHD1L1 may bind to chromobox protein homolog 7 (CBX7) and positively regulate its expression. The research concludes that PKHD1L1 can hinder LUAD progression by regulating CBX7-mediated Hippo signaling. [Extracted from the article]

A recent study conducted at Children's of Alabama in Birmingham has found that infants with severe congenital kidney disease can survive with the use of extracorporeal membrane oxygenation (ECMO) and kidney support therapy. Previously, ECMO was not used in this population due to the belief that it was not viable. However, the study found that out of 31 neonates with congenital kidney failure, five were placed on ECMO and four survived. The study suggests that meticulous ECMO, respiratory, nutritional, and kidney support therapies can lead to favorable long-term outcomes for these patients. Further research is needed to optimize outcomes in this population. [Extracted from the article]

A recent report from Johns Hopkins University School of Medicine discusses new research on liver diseases and conditions, specifically focusing on autosomal recessive polycystic kidney disease (ARPKD). The study highlights the need for new therapies to treat this genetic disorder, which can cause newborn morbidity and mortality. The researchers found that a CFTR modulator called VX-809 inhibits proliferation and limits bile duct malformation in a mouse model of ARPKD, suggesting a potential therapeutic pathway for treating the disease. [Extracted from the article]

A recent study conducted by researchers at Shahid Beheshti University of Medical Sciences has provided new insights into liver diseases and conditions, specifically focusing on polycystic liver disease (PLD). PLD is a rare condition that is observed in three genetic diseases and typically does not impair liver function. The diagnosis of PLD is primarily based on imaging, and genetic testing is only necessary in complex cases. The study highlights the underlying genetic causes and mechanisms of PLD, as well as current treatment options and potential future research directions. This information can be valuable for researchers and clinicians interested in PLD. [Extracted from the article]

A recent report from Great Ormond Street Hospital for Children NHS Foundation Trust in London discusses the research on renal ciliopathies, a group of genetic disorders that affect the function of the primary cilium in the kidney and other organs. The dysfunction of primary cilia leads to various clinical manifestations, including renal failure, cyst formation, and hypertension. The report summarizes the current understanding of the pathophysiological and pathological features of renal ciliopathies in childhood, including different types of kidney diseases. The genetic basis of these disorders has been well-established, with mutations in specific genes being responsible for the majority of cases. The report emphasizes the importance of clinicopathological correlation and genetic testing in understanding the mechanisms of these disorders. [Extracted from the article]

A recent study conducted by researchers at the University of Zagreb in Croatia focused on pediatric cystic kidney disease (CyKD), a condition characterized by renal cysts. The study analyzed data from a 12-year period and found that the most common form of CyKD was multicystic dysplastic kidney disease. The study also identified common symptoms such as abdominal distension, abdominal pain, and oliguria, as well as long-term complications including recurrent urinary tract infections, hypertension, chronic kidney disease (CKD), and end-stage renal disease (ESRD). This study provides valuable insights into the diagnosis and management of CyKD in children. [Extracted from the article]

According to a preprint abstract from biorxiv.org, a study was conducted on mice to investigate the role of the protein PKHD1L1 in hearing function. The study found that PKHD1L1 is required for the maintenance of the stereocilia bundle in sensory hair cells of the cochlea, which is essential for hearing. PKHD1L1-deficient mice displayed disruptions to bundle coherence and developed high-frequency hearing loss that progressed with age. Additionally, these mice were more susceptible to permanent hearing loss from noise exposure compared to wild-type mice. This research suggests that PKHD1L1 plays a crucial role in the development and maintenance of sensory hair bundles, which are necessary for hearing function and resilience to acoustic trauma and aging. [Extracted from the article]

A patent has been issued for a method of assessing the risk for genetic conditions using target-enriched multiplexed parallel analysis. The method involves preparing a sequencing library from a sample containing maternal and fetal DNA, hybridizing the library to a pool of single-stranded TArget Capture Sequences (TACS), isolating the enriched library, amplifying and sequencing it, and performing statistical analysis to determine maternal carrier status. The method also includes obtaining a paternal DNA sample and determining paternal carrier status, and ultimately assessing fetal risk of inheriting a genetic condition based on maternal and paternal carrier status. This method allows for the detection of genetic aberrations in small amounts of a sample and can simultaneously assess both fetal risk of inherited genetic conditions and genetic abnormalities. The patent describes a method for determining the status of a genetic condition or the fetal risk of inheriting a genetic condition. The method involves preparing a sequencing library from a sample containing maternal and fetal DNA, hybridizing the library to a pool of single-stranded TArget Capture Sequences (TACS), isolating the sequences that bind to the TACS to obtain an enriched library, and performing statistical analysis on the enriched library sequences to determine carrier status and fetal risk. The method can be used to detect various genetic abnormalities, including chromosomal aneuploidies and structural abnormalities. The patent provides detailed information on the specific techniques and conditions used in the method. [Extracted from the article]

A patent application has been submitted for the approval of an oral somatostatin receptor ligand (SRL) called oral octreotide for the treatment of various diseases, including polycystic disease, hypotension, intractable diarrhea, neuroendocrine tumors, and carcinoid syndrome. The invention also includes combination therapy with other therapeutic agents such as angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and statins. The oral administration of octreotide offers advantages over injectable forms, including avoiding painful injections and reducing breakthrough symptoms. The patent application provides detailed information on the background, summary, and claims of the invention. [Extracted from the article]

A report from Mayo Clinic in Rochester, Minnesota provides new information on liver diseases and conditions, specifically focusing on the genetic spectrum of polycystic kidney and liver diseases and the resulting phenotypes. Polycystic kidney diseases are inherited disorders characterized by cyst development in the kidney, with defects in primary cilia function playing a central role. Autosomal dominant polycystic kidney disease (ADPKD) is the most common form and accounts for a significant percentage of kidney failure cases. The report highlights the major genes associated with ADPKD and autosomal dominant polycystic liver disease, as well as the genetic complexity and overlap between these diseases. The researchers recommend using a next-generation sequencing panel for clinical testing due to the phenotypic and genic overlap. The research has been peer-reviewed and published in Advances In Kidney Disease and Health. [Extracted from the article]

A recent study examined the effectiveness of isolated kidney transplantation (KT) in children with autosomal recessive polycystic kidney disease (ARPKD) who did not have severe hepatic disease. The study found that isolated KT resulted in excellent short-term graft and patient survival, with no adverse events observed. However, long-term follow-up and larger studies are needed to further assess the efficacy of isolated KT in this subset of children with ARPKD. The study provides valuable insights for clinicians and researchers working in the field of pediatric transplantation. [Extracted from the article]

A recent study conducted at Children's National Hospital in Washington, D.C. explored the regulation of MYC expression in autosomal recessive polycystic kidney disease (ARPKD). The researchers found that MYC is overexpressed in the kidneys of ARPKD patients and in cystic kidneys of cpk mutant mice. They also discovered that the fibrocystin/polyductin (FPC) protein plays a role in regulating MYC expression. The study suggests that differences in FPC regulation of MYC expression may contribute to the phenotypic disparities between human patients with PKHD1 pathogenic variants and Pkhd1-mutant mice. [Extracted from the article]

Cellular Structures, Cytoplasm, Cytoplasmic Structures, Health and Medicine, Intracellular Space, Kidney, Mitochondria, Nephrology, Organelles, Science, Subcellular Fractions Keywords: Cellular Structures; Cytoplasm; Cytoplasmic Structures; Health and Medicine; Intracellular Space; Kidney; Mitochondria; Nephrology; Organelles; Science; Subcellular Fractions EN Cellular Structures Cytoplasm Cytoplasmic Structures Health and Medicine Intracellular Space Kidney Mitochondria Nephrology Organelles Science Subcellular Fractions 1090 1090 1 11/06/23 20231106 NES 231106 2023 NOV 6 (NewsRx) -- By a News Reporter-Staff News Editor at Gastroenterology Week -- A new study on science is now available. [Extracted from the article]

Keywords: Odense; Denmark; Europe; Genomics and Genetics EN Odense Denmark Europe Genomics and Genetics 580 580 1 10/30/23 20231103 NES 231103 2023 NOV 3 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators publish new report on Genomics and Genetics. The news reporters obtained a quote from the research from Odense University Hospital, "In more rare cases, sequence variants in DZIP1L are seen, encoding the basal body protein DAZ interacting protein 1-like protein (DZIP1L). [Extracted from the article]

Keywords: Congenital Diseases and Conditions; Congenital Hepatic Fibrosis; Genetics; Health and Medicine; Inflammation EN Congenital Diseases and Conditions Congenital Hepatic Fibrosis Genetics Health and Medicine Inflammation 928 928 1 10/09/23 20231010 NES 231010 2023 OCT 9 (NewsRx) -- By a News Reporter-Staff News Editor at Gastroenterology Week -- Investigators discuss new findings in congenital hepatic fibrosis. Congenital Diseases and Conditions, Congenital Hepatic Fibrosis, Genetics, Health and Medicine, Inflammation. [Extracted from the article]

Keywords: Congenital Diseases and Conditions; Congenital Hepatic Fibrosis; Health and Medicine EN Congenital Diseases and Conditions Congenital Hepatic Fibrosis Health and Medicine 90 90 1 10/03/23 20231002 NES 231002 2023 OCT 2 (NewsRx) -- By a News Reporter-Staff News Editor at Gastroenterology Week -- Fresh data on congenital hepatic fibrosis are presented in a new report. Congenital Diseases and Conditions, Health and Medicine, Congenital Hepatic Fibrosis. [Extracted from the article]

Decreased nitric oxide (NO) bioavailability seen in patients with hypertension seems to be the principal mechanism of hypertension causing priapism. Keywords: Cardiovascular Diseases and Conditions; Chemicals; Drugs and Therapies; Genetics; Health and Medicine; Hypertension; Nitric Oxide EN Cardiovascular Diseases and Conditions Chemicals Drugs and Therapies Genetics Health and Medicine Hypertension Nitric Oxide 916 916 1 09/25/23 20230929 NES 230929 2023 SEP 25 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators discuss new findings in hypertension. [Extracted from the article]

Keywords: Washington; State:District of Columbia; United States; North and Central America; Digestive System Diseases and Conditions; Genetics; Health and Medicine; Kidney; Liver Diseases and Conditions; Nephrology; Risk and Prevention EN Washington State:District of Columbia United States North and Central America Digestive System Diseases and Conditions Genetics Health and Medicine Kidney Liver Diseases and Conditions Nephrology Risk and Prevention 372 372 1 09/19/23 20230919 NES 230919 2023 SEP 18 (NewsRx) -- By a News Reporter-Staff News Editor at Gastroenterology Week -- Current study results on Liver Diseases and Conditions have been published. Key messagesThe mouse expresses cystic liver disease, but no kidney phenotype. [Extracted from the article]

Participant has a known hematologic disease other than anemia secondary to renal disease,(e.g., history of sickle cell disease, sickle cell anemia, hemoglobin sickle cell disease, or hemoglobin sickle cell beta thalassemia). Keywords: Aminotransferase; Anemia; Blood; Blood Cells; Blood Pressure; Bone Marrow; Bone Research; Cell Research; Clinical Research; Clinical Trials and Studies; Diagnostics and Screening; Dialysis; Enzymes and Coenzymes; Fatigue; Health and Medicine; Heart Rate; Hematologic Diseases and Conditions; Hematologic Diseases and Conditions - Anemia; Hematology; Hemic and Lymphatic Diseases and Conditions; Hemodynamics; Hospitals; Pediatrics; Pharmacokinetics; Pharmacology; Plasma; Quality of Life EN Aminotransferase Anemia Blood Blood Cells Blood Pressure Bone Marrow Bone Research Cell Research Clinical Research Clinical Trials and Studies Diagnostics and Screening Dialysis Enzymes and Coenzymes Fatigue Health and Medicine Heart Rate Hematologic Diseases and Conditions Hematologic Diseases and Conditions - Anemia Hematology Hemic and Lymphatic Diseases and Conditions Hemodynamics Hospitals Pediatrics Pharmacokinetics Pharmacology Plasma Quality of Life 73 73 1 08/14/23 20230814 NES 230814 2023 AUG 17 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Staff editors report on the newly launched clinical trial, NCT05970172, which has the following summary description: "Roxadustat is a licensed medicine to treat anemia in adults with chronic kidney disease (CKD). Current treatment for anemia is to have injections of medicines called erythropoietin stimulating agents (also known as ESAs) to help the bone marrow make more red blood cells. [Extracted from the article]

Anemia, Autoimmune Diseases and Conditions, Autoimmune Hemolytic Anemia, Autoimmunity, Health and Medicine, Hematologic Diseases and Conditions, Hematology, Hemic and Lymphatic Diseases and Conditions, Hemolytic, Hemolytic Anemia, Immunology, Male Kidney Diseases and Conditions, Men's Health, Polycystic Kidney Disease Keywords: Anemia; Autoimmune Diseases and Conditions; Autoimmune Hemolytic Anemia; Autoimmunity; Health and Medicine; Hematologic Diseases and Conditions; Hematology; Hemic and Lymphatic Diseases and Conditions; Hemolytic; Hemolytic Anemia; Immunology; Male Kidney Diseases and Conditions; Men's Health; Polycystic Kidney Disease EN Anemia Autoimmune Diseases and Conditions Autoimmune Hemolytic Anemia Autoimmunity Health and Medicine Hematologic Diseases and Conditions Hematology Hemic and Lymphatic Diseases and Conditions Hemolytic Hemolytic Anemia Immunology Male Kidney Diseases and Conditions Men's Health Polycystic Kidney Disease 385 385 1 07/31/23 20230801 NES 230801 2023 AUG 3 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- A new study on polycystic kidney disease is now available. [Extracted from the article]

Keywords: 11-Hydroxycorticosteroids; Adrenal Cortex Hormones; Aldosterone; Angiotensin Receptors; Angiotensins; Autacoids; Biological Factors; Chronic Kidney Disease; Drugs and Therapies; Enzymes and Coenzymes; G-Protein-Coupled Receptors; Genetics; Health and Medicine; Hyperkalemia; Kidney Diseases and Conditions; Membrane Proteins; Metabolic Diseases and Conditions; Nephrology; Nephropathy; Neuropeptide Receptors; Neuropeptides; Nutritional and Metabolic Diseases and Conditions; Oligopeptides; Patent Application; Peptide Hormones; Peptide Proteins; Peptide Receptors; Peptides; Pharmaceuticals; Proteins; Renin; Risk and Prevention; Type 1 Receptor; Type 2 Receptor; Water-Electrolyte Imbalance EN 11-Hydroxycorticosteroids Adrenal Cortex Hormones Aldosterone Angiotensin Receptors Angiotensins Autacoids Biological Factors Chronic Kidney Disease Drugs and Therapies Enzymes and Coenzymes G-Protein-Coupled Receptors Genetics Health and Medicine Hyperkalemia Kidney Diseases and Conditions Membrane Proteins Metabolic Diseases and Conditions Nephrology Nephropathy Neuropeptide Receptors Neuropeptides Nutritional and Metabolic Diseases and Conditions Oligopeptides Patent Application Peptide Hormones Peptide Proteins Peptide Receptors Peptides Pharmaceuticals Proteins Renin Risk and Prevention Type 1 Receptor Type 2 Receptor Water-Electrolyte Imbalance 1492 1492 1 07/24/23 20230724 NES 230724 2023 JUL 24 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- A patent application by the inventors BASCANDS, Jean-Loup (Sainte Clotilde - la Reunion, FR); KLEIN, Julie (Toulouse Cedex 4, FR); SCHANSTRA, Joost (Toulouse Cedex 4, FR); SCHILTZ, Odile (Toulouse Cedex 4, FR), filed on June 10, 2021, was made available online on July 6, 2023, according to news reporting originating from Washington, D.C., by NewsRx correspondents. [Extracted from the article]

Keywords: Birmingham; State:Alabama; United States; North and Central America; Enzymes and Coenzymes; Epithelial Cells; Health and Medicine; Kidney; Ligases; Nephrology; Peptides and Proteins; Proteins; Proteome EN Birmingham State:Alabama United States North and Central America Enzymes and Coenzymes Epithelial Cells Health and Medicine Kidney Ligases Nephrology Peptides and Proteins Proteins Proteome 5106 5106 1 07/17/23 20230721 NES 230721 2023 JUL 21 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- New research on Peptides and Proteins - Proteome is the subject of a report. For more information on this research see: Cystin Is Required for Maintaining Fibrocystin (Fpc) Levels and Safeguarding Proteome Integrity In Mouse Renal Epithelial Cells a Mechanistic Connection Between the Kidney Defects In Cpk Mice and Human Arpkd. [Extracted from the article]

Keywords: Genetics; Life Sciences EN Genetics Life Sciences 1691 1691 1 07/17/23 20230721 NES 230721 2023 JUL 21 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators publish new report on genetics. According to news reporting originating from Nanjing, People's Republic of China, by NewsRx correspondents, research stated, "Variants of the polycystic kidney and hepatic disease 1 (PKHD1) gene are associated with autosomal recessive polycystic kidney disease (ARPKD). [Extracted from the article]

Keywords: Diagnostics and Screening; Digestive System Diseases and Conditions; Health and Medicine; Liver Diseases and Conditions EN Diagnostics and Screening Digestive System Diseases and Conditions Health and Medicine Liver Diseases and Conditions 697 697 1 07/17/23 20230721 NES 230721 2023 JUL 21 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- A new study on liver diseases and conditions is now available. Our news editors obtained a quote from the research from Ulsan University Hospital: "It is classified into three types: isolated autosomal dominant PLD, PLD with autosomal dominant polycystic kidney disease, and PLD with autosomal recessive polycystic kidney disease. Diagnostics and Screening, Digestive System Diseases and Conditions, Health and Medicine, Liver Diseases and Conditions. [Extracted from the article]

News editors obtained the following quote from the background information supplied by the inventors: "The use in clinical trials of injectable octreotide or lanreotide-which are sonatostatin receptor ligands (SRLs)-for the treatment of various diseases e.g. polycystic liver disease and polycystic kidney disease is described in the literature. Another method of treatment comprises administration to the subject of a therapeutically effective amount of an oral somatostatin receptor ligand (SRL) e.g. oral octreotide in combination with a therapeutically effective amount of an Src kinase inhibitor (also termed a tyrosine kinase inhibitor) e.g. bosutinib, administered orally; bosutinib is marketed under the trade name Bosulif(R). Another method of treatment comprises administration to the subject of a therapeutically effective amount of an oral somatostatin receptor ligand (SRL) e.g. oral octreotide in combination with a therapeutically effective amount of a drug which treats diarrhea e.g. loperamide, cholestyramine, atropine or an opioid (e.g. codeine, diphenoxylate or difenoxin). [Extracted from the article]

Our news correspondents report that additional information may be obtained by contacting Huarong Li, Chidrens Hosp, Capital Institute of Pediatrics, Dept. of Nephrology, Beijing, People's Republic of China. Keywords: Beijing; People's Republic of China; Asia; Diabetes Research; Genetics EN Beijing People's Republic of China Asia Diabetes Research Genetics 154 154 1 05/15/23 20230515 NES 230515 2023 MAY 15 (NewsRx) -- By a News Reporter-Staff News Editor at Diabetes Week -- Data detailed on Diabetes Research have been presented. [Extracted from the article]

Keywords: Bern; Switzerland; Europe; Genomics and Genetics; Diagnostics and Screening; Health and Medicine; Kidney; Nephrology EN Bern Switzerland Europe Genomics and Genetics Diagnostics and Screening Health and Medicine Kidney Nephrology 1244 1244 1 04/17/23 20230421 NES 230421 2023 APR 21 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- New research on Genomics and Genetics is the subject of a report. Keywords for this news article include: Bern, Switzerland, Europe, Genomics and Genetics, Diagnostics and Screening, Health and Medicine, Kidney, Nephrology, Bern University Hospital. [Extracted from the article]

For more information on this research see: Shift from severe hypotension to salt-dependent hypertension in a child with autosomal recessive polycystic kidney disease after bilateral nephrectomies: a case report. Keywords: Vilnius; Lithuania; Europe; Anions; Blood Pressure; Cardiovascular Diseases and Conditions; Chemicals; Chlorides; Drugs and Therapies; Health and Medicine; Hydrochloric Acid; Hypertension; Hypotension; Nasal Lubricants and Irrigations; Nephrectomy; Pediatrics; Pharmaceuticals; Respiratory Agents; Sodium Chloride; Sodium Compounds; Surgery EN Vilnius Lithuania Europe Anions Blood Pressure Cardiovascular Diseases and Conditions Chemicals Chlorides Drugs and Therapies Health and Medicine Hydrochloric Acid Hypertension Hypotension Nasal Lubricants and Irrigations Nephrectomy Pediatrics Pharmaceuticals Respiratory Agents Sodium Chloride Sodium Compounds Surgery 659 659 1 04/17/23 20230421 NES 230421 2023 APR 22 (NewsRx) -- By a News Reporter-Staff News Editor at Pediatrics Week -- New research on Cardiovascular Diseases and Conditions - Hypotension is the subject of a report. [Extracted from the article]

In one embodiment, the 5' ribozyme of the synthetic intron is one or more selected from the group consisting of: a member of the HDV family of ribozymes, a member of the HDV family of ribozymes, and VS-S ribozyme recognition sequence. In one embodiment, said small RNA sequence comprises one or more selected from the group consisting of: microRNA (miRNA), Piwi-interacting RNA (piRNA), small interfering RNA (siRNA), small nucleolar RNA (snoRNAs), small tRNA-derived RNA (tsRNA), small rDNA-derived RNA (srRNA) and small nuclear RNA (snRNA). In one embodiment, said small RNA sequence comprises one or more selected from the group consisting of: microRNA (miRNA), Piwi-interacting RNA (piRNA), small interfering RNA (siRNA), small nucleolar RNA (snoRNAs), small tRNA-derived RNA (tsRNA), small rDNA-derived RNA (srRNA) and small nuclear RNA (snRNA). The method of any of claims 11-16, wherein the method further comprises administering to the cell or tissue one or more additional nucleic acid molecules encoding one or more additional RNA molecules, each additional RNA molecule comprising a coding region encoding a domain of the protein of interest; a 5' ribozyme; and a 3' ribozyme. [Extracted from the article]

ADPKD patients with a very early onset of the disease (VEOADPKD) develop hypertension similarly to patients with ARPKD. Cardiology, Cardiovascular, Cardiovascular Diseases and Conditions, Cardiovascular Research, Drugs and Therapies, Genetics, Health and Medicine, Hypertension, Pediatrics, Risk and Prevention Keywords: Cardiology; Cardiovascular; Cardiovascular Diseases and Conditions; Cardiovascular Research; Drugs and Therapies; Genetics; Health and Medicine; Hypertension; Pediatrics; Risk and Prevention EN Cardiology Cardiovascular Cardiovascular Diseases and Conditions Cardiovascular Research Drugs and Therapies Genetics Health and Medicine Hypertension Pediatrics Risk and Prevention 619 619 1 03/27/23 20230327 NES 230327 2023 MAR 27 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- New study results on hypertension have been published. [Extracted from the article]

Nutritional and Metabolic Diseases and Conditions - Malnutrition New research on Nutritional and Metabolic Diseases andConditions - Malnutrition is the subject of a report. Themedian age of the ARPKD patients at diagnosis was lower than themedian age of ADPKD patients (10.5 months [range: 0-15 years]vs. In total, 11 (52.4%) ARPKD patientshad malnutrition; 7 (33.3%) patients had growth retardation atpresentation; and 4 (19%) patients had both malnutrition andgrowth retardation. [Extracted from the article]