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A new study conducted by researchers at the University of Saskatchewan explores the underlying mechanisms of neurodegeneration in multiple sclerosis (MS). The study focuses on the dysfunction of the RNA binding protein hnRNP A1, which leads to altered neuronal RNA splicing and contributes to neurodegeneration in MS. Through RNA sequencing and experimental autoimmune encephalomyelitis models, the researchers identified differential expression and aberrant splicing of hnRNP A1 target RNAs involved in neuronal function and RNA homeostasis. These findings suggest that hnRNP A1 dysfunction plays a role in the progression of MS and could potentially be targeted for therapeutic interventions. [Extracted from the article]

A recent study conducted by researchers at the University of Regina explores the effects of different exercise approaches on walking and central nervous system (CNS) function in individuals with multiple sclerosis (MS). The study compares the effects of "task-oriented exercise" to "generalized resistance and aerobic exercise" and a "stretching control" on walking speed and related neural changes. The researchers hypothesize that task-oriented exercise will have a greater impact on walking speed and CNS function. The study is a single-blinded, three-arm randomized controlled trial conducted in Saskatchewan, Canada, and the exercise interventions are delivered over a 12-week period. The findings of this study will contribute to the development of specialized exercise programming for individuals with MS and support the use of exercise as a form of treatment. [Extracted from the article]