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A recent study conducted by researchers from the University of Virginia Cancer Center explored the role of natural killer (NK) cells and CD8 T cells in non-small cell lung cancer (NSCLC). The researchers found that NK cells and CD8 T cells were able to control the progression of NSCLC tumors, despite the loss of major histocompatibility complex class I (MHC-I) in the tumor cells. The study also revealed that the presence of interferon-gamma (IFNg) was associated with the co-association of NK and CD8 T cells in MHC-I-bearing tumors. The findings suggest that the activation of lymphocytes in NSCLC is coordinated and regulated. [Extracted from the article]

A recent report from the University of Virginia discusses the presence of tertiary lymphoid structures (TLS) in desmoplastic melanoma (DM) and their potential impact on immune activity. The researchers found that TLS in DM had higher densities of CD8+ T-cells and CD20+ B-cells, as well as increased lymphocyte proliferation, compared to non-desmoplastic melanomas (NDMM). Additionally, the study suggests that TLS in DM may have enhanced immune cell trafficking between the tumor and TLS. These findings highlight the potential differences in immune activity across different subsets of melanoma and provide insights into the immunological characteristics of DM. [Extracted from the article]