1. Autoimmunity and beta cell regeneration in mouse and human type 1 diabetes: the peace is not enough.
- Author
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Ablamunits V, Sherry NA, Kushner JA, and Herold KC
- Subjects
- Animals, Autoimmunity, Diabetes Mellitus, Experimental pathology, Diabetes Mellitus, Experimental physiopathology, Diabetes Mellitus, Type 1 pathology, Glucose Transporter Type 2 analysis, Humans, Insulin analysis, Insulin-Secreting Cells immunology, Insulin-Secreting Cells physiology, Islets of Langerhans immunology, Islets of Langerhans pathology, Islets of Langerhans physiopathology, Male, Mice, Mice, Inbred NOD, Regeneration, Diabetes Mellitus, Experimental immunology, Diabetes Mellitus, Type 1 immunology, Insulin-Secreting Cells pathology
- Abstract
Accumulating data from animal models of type 1 diabetes and some findings from clinical studies suggest that autoimmune destruction of islet beta cells is associated with enhanced beta cell regeneration. Successful immune therapies, aimed at preservation of islet cell mass, result in a remarkable reduction of beta cell regeneration. Treated or not, as long as the task of treatment is limited by "making peace" with autoimmunity, the process of beta cell loss continues. Additional therapeutic modalities capable of stimulating beta cell regeneration in the absence of active autoimmune destruction are urgently needed.
- Published
- 2007
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