1. Proximal reflux: biochemical mediators, markers, therapeutic targets, and clinical correlations.
- Author
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Klimara MJ, Randall DR, Allen J, Figueredo E, and Johnston N
- Subjects
- Biomarkers metabolism, Humans, Respiratory Aspiration of Gastric Contents diagnosis, Respiratory Aspiration of Gastric Contents metabolism, Respiratory Aspiration of Gastric Contents physiopathology, Respiratory Aspiration of Gastric Contents therapy
- Abstract
Airway reflux is implicated in the pathophysiology of a wide range of adult and pediatric upper and lower airway diseases. However, the diagnosis of proximal reflux-associated disease remains challenging due to evolving clinical criteria and institutional and regional variances in diagnostic practices. Evidence suggests that nonacidic contents of reflux may serve as both pathologic mediators of and biomarkers for reflux in the upper airway. Furthermore, they offer potential pharmaceutical and surgical intervention targets and are the focus of novel clinical diagnostic tools currently under investigation., (© 2020 New York Academy of Sciences.)
- Published
- 2020
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