1. Trastuzumab — Mechanism of Action and Use in Clinical Practice.
- Author
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Hudis, Clifford A.
- Subjects
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BREAST cancer treatment , *TRASTUZUMAB , *MONOCLONAL antibodies , *DRUG therapy , *GROWTH factors , *CELL proliferation , *CELL growth , *CLINICAL medicine , *CLINICAL trial registries , *PREVENTION , *THERAPEUTICS - Abstract
This article presents a review of the breast cancer medication trastuzumab, its mechanism of action and clinical value. In general, patients with breast-cancer cells that overexpress human epidermal growth factor receptor type 2 (HER2) have decreased overall survival and may have differential responses to treatment. Trastuzumab works by binding to the domain of HER2 and inhibiting the proliferation and survival of HER2-dependent tumors. Many studies of the drug are outlined. The most pivotal of all showed that the activity of trastuzumab in combination with chemotherapy was more effective than chemotherapy alone.
- Published
- 2007
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