1. NEUROPROTECTIVE EFFECT AND REACTIVE OXYGEN SPECIES SCAVENGING CAPACITY OF MANGOSTEEN PERICARP EXTRACT IN CULTURED NEURONS.
- Author
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Guzmán-Beltrán, Silvia, Orozco-Ibarra, Marisol, González-Cuahutencos, Octavio, Victoria-Mares, Sonia, Merchand-Reyes, Giovanna, Medina-Campos, Omar N., and Pedraza-Chaverri, José
- Subjects
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MANGOSTEEN , *TRADITIONAL medicine , *PLANT extracts , *NEUROTOXICOLOGY , *NEURONS , *SUPEROXIDES - Abstract
The pericarp of mangosteen (Garcinia mangostana L.) (GML) has been used in traditional medicine for the treatment of different illnesses. The potential protective effect of GML pericarp extract and of a commercial mangosteen juice against 3-nitropropionic acid (3-NP)-induced neurotoxicity and reactive oxygen species (ROS) production in cultured cerebellar granule neurons (CGNs) as well their in vitro ROS and reactive nitrogen species (RNS) scavenging capacity were studied in the present paper. The extract and the juice were able to ameliorate 3-NP induced cytotoxicity that was closely associated to the decrease in 3-NP induced ROS production in CGNs. The extract and the juice scavenged in a concentration-dependent way superoxide anion, hydroxyl radical, hypochlorous acid, and peroxynitrite. The extract also scavenged singlet oxygen. It is concluded that the antioxidant properties of both GML pericarp extract and mangosteen juice are involved in the neuroprotective effect against 3-NP in CGNs. [ABSTRACT FROM AUTHOR]
- Published
- 2008