Search

The antiglobulin serum (AGS) against spotted fever immunoglobulin of guinea pigs was studied for its effect on the in vitro created immune complex rickettsiae + antibody in experiments using the procedure of laboratory cultivation of Rickettsiae prowazekii according to Weigl. The biological activity of the pathogen is shown to be restored under the action of AGS. This fact may be used for detecting the antigen + antibody complexes in case of the spotted fever and for studying their role in the relapsive forms of the disease.

The dynamic light-optic and electron microscopic examination of the organs of experimental animals with the influenza infection have revealed the most pronounced pathology in vessels of the lung and brain microcirculation. The early developing perivascular edema around capillaries which is induced by an increase in the transcellular transport without a disturbance of the dense contact integrity is observed in the brain tissue. Variations in the lung microvessels manifested in a rise of the pinocytosis activity of endothelial cells, in a change of the luminal surface profile and damage of the supermembrane layer. A reversible aggregation of plate and erythrocytes was observed in the lung and brain microvessel lumen at early periods. The revealed changes, including the main of them--microvessel permeability disturbance, are associated with the dynamics of the concentration of the influenza virus and its complexes with antibodies in the organs under study.