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Possible mechanisms of unilateral ischemic insults in CA1 region of hippocampus and anterior dorsal nuclei of thalamus after bilateral occlusion of common carotid arteries in rats with different types of behavior are discussed.

Permanent bilateral occlusion of common carotid arteries in rats with different behaviour types led to non-uniform structural alterations in the hippocampus. In the majority of animals, morphological changes were diffuse (i.e. having no clear localisation in a definite region of the brain structure) and symmetrical (i.e. having no evident prevalence in one of the brain hemispheres). In 6.6% of survived animals, apart from diffuse structural changes, local and asymmetrical sites of lesions occurred in the hippocampus and mostly in the dorso-lateral thalamic nuclei of the right brain hemisphere. These local zones of strongly pronounced pathology corresponded to ischemic insults which were described earlier by other authors under transient cerebral ischemia. It is supposed that the occurrence of unilateral ischemic insults in a definite region of hippocampus and thalamus after bilateral occlusion of common carotid arteries is due to individual features of the anatomy of the vascular brain system which are found more frequently in rats with passive type of behaviour and in rats of the middle group than in rats with active type of behaviour.

Antioxidant preparation "Aekol" containing vitamins A, E, and K3, was shown to possess antidepressant properties and to exert a prophylactic effect on behavioural (psychoemotional) disturbances induced by a chronic stress in rats: a depressive condition associated with an enhanced anxiety, elimination of individual differences in behaviour, weakening of the relationships among behavioural parameters recorded in the same animal in three different tests.