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Your search keyword '"Chukicheva IIu"' showing total 3 results
Start Over Author "Chukicheva IIu" Publisher nauka
3 results on '"Chukicheva IIu"'

1. [Membrane protective properties of diastereomers of methylpheophorbide a 13(2)-n-n-octyl-N-(2-hydroxy-3-isobornyl-5-methylbenzyl)amide].

Author

Buravlev EV, Belykh DV, Chukicheva IIu, Tarabukina IS, Shevchenko OG, and Kutchin AV

Subjects
Animals, Chlorophyll chemical synthesis, Chlorophyll chemistry, Chlorophyll pharmacology, Chromatography, High Pressure Liquid, Cresols chemistry, Erythrocytes drug effects, Hydrogen Peroxide chemistry, Mice, Molecular Structure, Protective Agents chemical synthesis, Protective Agents pharmacology, Stereoisomerism, Camphanes chemistry, Chlorophyll analogs & derivatives, Membranes drug effects, Protective Agents chemistry
Abstract

Two diastereomers of methylpheophorbide a 13(2)-N-n-octyl-N-(2-hydroxy-3-isobornyl-5-methylbenzyl)amide were obtained from (+)- and (-)-enantiomers of 2-isobornyl-4-methylphenol. Evaluation of membrane protective and antioxidant activity of individual diastereomers on the model of H2O2-induced hemolysis of blood erythrocytes showed that the stereochemistry of isobornyl substituent in the synthesized conjugates has no effect on their biological activity.

Published
2013
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2. [Ionic conjugates of sulfate carboxymethyl cellulose with dialkylaminomethyl derivatives of 2-isobornyl-4-methylphenol: synthesis and study of anti-inflammatory and analgesic activity].

Author

Chukicheva IIu, Buravlev EV, Torlopov MA, Vikharev IuB, Anikina LV, and Grishko VV

Subjects
Animals, Formaldehyde toxicity, Mice, Solubility, Sulfates chemical synthesis, Sulfates chemistry, Sulfates pharmacology, Water chemistry, Carboxymethylcellulose Sodium analogs & derivatives, Carboxymethylcellulose Sodium chemical synthesis, Carboxymethylcellulose Sodium chemistry, Carboxymethylcellulose Sodium pharmacology, Inflammation chemically induced, Inflammation drug therapy, Pain drug therapy, Pain pathology, Pain Measurement drug effects
Abstract

Water-soluble sulfate polysalts of carboxymethyl cellulose and tertiary aminomethyl derivatives of 2-isobornyl-4-methylphenol was obtained. For the synthesized conjugates investigated in vivo anti-inflammatory activity in the test of acute formalin inflammation and analgesic activity in tests the "hot plate" and "vinegar cramps".

Published
2012
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3. [Synthesis of novel terpenophenol-chlorin conjugates and evaluation of their membranotropic and membrane protective properties].

Author

Belykh DV, Buravlev EV, Chukicheva IIu, Tarabukina IS, Shevchenko OG, Pliusnina SN, and Kuchin AV

Subjects
Animals, Chlorophyll analogs & derivatives, Chlorophyll chemistry, Mice, Erythrocyte Membrane chemistry, Hemolysis drug effects, Hydrocarbons, Chlorinated chemical synthesis, Hydrocarbons, Chlorinated chemistry, Hydrocarbons, Chlorinated pharmacology, Lipid Peroxidation drug effects, Phenols chemical synthesis, Phenols chemistry, Phenols pharmacology, Terpenes chemical synthesis, Terpenes chemistry, Terpenes pharmacology
Abstract

A series of terpenophenol-chlorin conjugates where terpenophenolic fragment has amide bond with macrocycle of methylpheophorbide a, formed by amidation of 13(2)-ester group were obtained by interaction of methylpheophorbide a and ortho-aminomethyl derivatives of 2-isobornyl-4-methylphenol. The substances investigated ability to interact with the cell membrane was shown in blood erythrocytes surface structure with scanning electron microscope. The conjugates studied were established to have antioxidant and membrane protective properties resulted from inhibiting H2O2-induced erythrocytes hemolysis and decrease of lipid peroxidation secondary product accumulation.

Published
2012
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