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1. [The effect of leu-enkephalin and its synthetic analog on the behavior of rats with different sensitivities to ethanol].

Author

Liashev IuD, Sever'ianova LA, and Bobyntsev II

Subjects
Animals, Behavior, Animal physiology, Disease Susceptibility physiopathology, Dose-Response Relationship, Drug, Male, Pain physiopathology, Rats, Sleep drug effects, Sleep physiology, Stress, Physiological physiopathology, Alcohol Drinking physiopathology, Behavior, Animal drug effects, Enkephalin, Leucine analogs & derivatives, Enkephalin, Leucine pharmacology
Abstract

Leu-enkephalin and its analogue N 171 increased the pain thresholds and reduced the affective aggression in unrestrained male rats. The N 171 manifested a greater analgesic and antiaggresiogenic effect, particularly in i.p. administration. Preliminary administration of peptides manifested a more obvious effect in alcohol-preferring rats under painful stress.

Published
1991

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