1. A new molecular classification to drive precision treatment strategies in primary Sjogren's syndrome
- Author
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Soret, Perrine, Le Dantec, Christelle, Desvaux, Emiko, Foulquier, Nathan, Chassagnol, Bastien, Hubert, Sandra, Jamin, Christophe, Barturen, Guillermo, Desachy, Guillaume, Devauchelle-Pensec, Valerie, Boudjeniba, Cheiema, Cornec, Divi, Saraux, Alain, Jousse-Joulin, Sandrine, Barbarroja, Nuria, Rodriguez-Pinto, Ignasi, De Langhe, Ellen, Beretta, Lorenzo, Chizzolini, Carlo, Kovacs, Laszlo, Witte, Torsten, Bettacchioli, Eleonore, Buttgereit, Anne, Makowska, Zuzanna, Lesche, Ralf, Orietta Borghi, Maria, Martin, Javier, Courtade-Gaiani, Sophie, Xuereb, Laura, Guedj, Mickael, Moingeon, Philippe, Alarcon-Riquelme, Marta E., Laigle, Laurence, Pers, Jacques-Olivier, Vigone, Barbara, Lauwerys, Bernard, Ducreux, Julie, Maudoux, Anne-Lise, Vasconcelos, Carlos, Tavares, Ana, Neves, Esmeralda, Faria, Raquel, Brandao, Mariana, Campar, Ana, Marinho, Antonio, Farinha, Fatima, Almeida, Isabel, Gonzalez-Gay Mantecon, Miguel Angel, Alonso, Ricardo Blanco, Martinez, Alfonso Corrales, Cervera, Ricard, Espinosa, Gerard, Lories, Rik, Hunzelmann, Nicolas, Belz, Doreen, Baerlecken, Niklas, Stummvoll, Georg, Zauner, Michael, Lehner, Michaela, Collantes, Eduardo, Ortega-Castro, Rafaela, Angeles Aguirre-Zamorano, Ma, Carmen Castro-Villegas, Ma, Jimenez Gomez, Yolanda, Ortego, Norberto, Fernandez Roldan, Maria Concepcion, Raya, Enrique, Moleon, Inmaculada Jimenez, de Ramon, Enrique, Quintero, Isabel Diaz, Meroni, Pier Luigi, Gerosa, Maria, Schioppo, Tommaso, Artusi, Carolina, Dulic, Sonja, Kadar, Gabriella, Hiepe, Falk, Gerl, Velia, Thiel, Silvia, Maresca, Manuel Rodriguez, Lopez-Berrio, Antonio, Aguilar-Quesada, Rocio, Navarro-Linares, Hector, Ioannou, Yiannis, Chamberlain, Chris, Marovac, Jacqueline, Alarcon Riquelme, Marta, Gomes Anjos, Tania, Maranon, Concepcion, Le Lann, Lucas, Simon, Quentin, Rouviere, Benedicte, Varela, Nieves, Muchmore, Brian, Dufour, Aleksandra, Alvarez, Montserrat, Cremer, Jonathan, Lopez-Pedrera, Chary, Ger, Velia, Khodadadi, Laleh, Cheng, Qingyu, De Groof, Aurelie, Trombetta, Elena, Li, Tianlu, Alvarez-Errico, Damiana, Kniesch, Katja, Azevedo, Nancy, Rao, Sambasiva, Jouve, Pierre-Emmanuel, Soret, Perrine, Le Dantec, Christelle, Desvaux, Emiko, Foulquier, Nathan, Chassagnol, Bastien, Hubert, Sandra, Jamin, Christophe, Barturen, Guillermo, Desachy, Guillaume, Devauchelle-Pensec, Valerie, Boudjeniba, Cheiema, Cornec, Divi, Saraux, Alain, Jousse-Joulin, Sandrine, Barbarroja, Nuria, Rodriguez-Pinto, Ignasi, De Langhe, Ellen, Beretta, Lorenzo, Chizzolini, Carlo, Kovacs, Laszlo, Witte, Torsten, Bettacchioli, Eleonore, Buttgereit, Anne, Makowska, Zuzanna, Lesche, Ralf, Orietta Borghi, Maria, Martin, Javier, Courtade-Gaiani, Sophie, Xuereb, Laura, Guedj, Mickael, Moingeon, Philippe, Alarcon-Riquelme, Marta E., Laigle, Laurence, Pers, Jacques-Olivier, Vigone, Barbara, Lauwerys, Bernard, Ducreux, Julie, Maudoux, Anne-Lise, Vasconcelos, Carlos, Tavares, Ana, Neves, Esmeralda, Faria, Raquel, Brandao, Mariana, Campar, Ana, Marinho, Antonio, Farinha, Fatima, Almeida, Isabel, Gonzalez-Gay Mantecon, Miguel Angel, Alonso, Ricardo Blanco, Martinez, Alfonso Corrales, Cervera, Ricard, Espinosa, Gerard, Lories, Rik, Hunzelmann, Nicolas, Belz, Doreen, Baerlecken, Niklas, Stummvoll, Georg, Zauner, Michael, Lehner, Michaela, Collantes, Eduardo, Ortega-Castro, Rafaela, Angeles Aguirre-Zamorano, Ma, Carmen Castro-Villegas, Ma, Jimenez Gomez, Yolanda, Ortego, Norberto, Fernandez Roldan, Maria Concepcion, Raya, Enrique, Moleon, Inmaculada Jimenez, de Ramon, Enrique, Quintero, Isabel Diaz, Meroni, Pier Luigi, Gerosa, Maria, Schioppo, Tommaso, Artusi, Carolina, Dulic, Sonja, Kadar, Gabriella, Hiepe, Falk, Gerl, Velia, Thiel, Silvia, Maresca, Manuel Rodriguez, Lopez-Berrio, Antonio, Aguilar-Quesada, Rocio, Navarro-Linares, Hector, Ioannou, Yiannis, Chamberlain, Chris, Marovac, Jacqueline, Alarcon Riquelme, Marta, Gomes Anjos, Tania, Maranon, Concepcion, Le Lann, Lucas, Simon, Quentin, Rouviere, Benedicte, Varela, Nieves, Muchmore, Brian, Dufour, Aleksandra, Alvarez, Montserrat, Cremer, Jonathan, Lopez-Pedrera, Chary, Ger, Velia, Khodadadi, Laleh, Cheng, Qingyu, De Groof, Aurelie, Trombetta, Elena, Li, Tianlu, Alvarez-Errico, Damiana, Kniesch, Katja, Azevedo, Nancy, Rao, Sambasiva, and Jouve, Pierre-Emmanuel
- Abstract
There is currently no approved treatment for primary Sjogren's syndrome, a disease that primarily affects adult women. The difficulty in developing effective therapies is -in part- because of the heterogeneity in the clinical manifestation and pathophysiology of the disease. Finding common molecular signatures among patient subgroups could improve our understanding of disease etiology, and facilitate the development of targeted therapeutics. Here, we report, in a cross-sectional cohort, a molecular classification scheme for Sjogren's syndrome patients based on the multi-omic profiling of whole blood samples from a European cohort of over 300 patients, and a similar number of age and gender-matched healthy volunteers. Using transcriptomic, genomic, epigenetic, cytokine expression and flow cytometry data, combined with clinical parameters, we identify four groups of patients with distinct patterns of immune dysregulation. The biomarkers we identify can be used by machine learning classifiers to sort future patients into subgroups, allowing the re-evaluation of response to treatments in clinical trials. Sjogren's syndrome, a disease that primarily affects women, is poorly understood. Here, the authors combine data from a large cohort of patients and healthy controls to identify biomarkers that distinguish patient subgroups to improve our understanding of the disease and facilitate drug development.
- Published
- 2021