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Your search keyword '"van Vliet, Arno L W"' showing total 3 results
Start Over Author "van Vliet, Arno L W" Publisher nature publishing group
3 results on '"van Vliet, Arno L W"'

1. Inhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association

Author

LS Virologie, dI&I I&I-1, Sub Biomol.Mass Spectrometry & Proteom., Virologie, dB&C I&I, Sub NMR Spectroscopy, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Rabouw, Huib H, Visser, Linda J, Passchier, Tim C, Langereis, Martijn A, Liu, Fan, Giansanti, Piero, van Vliet, Arno L W, Dekker, José G, van der Grein, Susanne G, Saucedo, Jesús G, Anand, Aditya A, Trellet, Mikael E, Bonvin, Alexandre M J J, Walter, Peter, Heck, Albert J R, de Groot, Raoul J, van Kuppeveld, Frank J M, LS Virologie, dI&I I&I-1, Sub Biomol.Mass Spectrometry & Proteom., Virologie, dB&C I&I, Sub NMR Spectroscopy, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Rabouw, Huib H, Visser, Linda J, Passchier, Tim C, Langereis, Martijn A, Liu, Fan, Giansanti, Piero, van Vliet, Arno L W, Dekker, José G, van der Grein, Susanne G, Saucedo, Jesús G, Anand, Aditya A, Trellet, Mikael E, Bonvin, Alexandre M J J, Walter, Peter, Heck, Albert J R, de Groot, Raoul J, and van Kuppeveld, Frank J M

Published
2020

2. Bypassing pan-enterovirus host factor PLA2G16

Author

LS Virologie, dI&I I&I-1, Baggen, Jim, Liu, Yue, Lyoo, Heyrhyoung, van Vliet, Arno L W, Wahedi, Maryam, de Bruin, Jost W, Roberts, Richard W, Overduin, Pieter, Meijer, Adam, Rossmann, Michael G, Thibaut, Hendrik Jan, van Kuppeveld, Frank J M, LS Virologie, dI&I I&I-1, Baggen, Jim, Liu, Yue, Lyoo, Heyrhyoung, van Vliet, Arno L W, Wahedi, Maryam, de Bruin, Jost W, Roberts, Richard W, Overduin, Pieter, Meijer, Adam, Rossmann, Michael G, Thibaut, Hendrik Jan, and van Kuppeveld, Frank J M

Published
2019

3. Inhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association.

Author

Rabouw HH, Visser LJ, Passchier TC, Langereis MA, Liu F, Giansanti P, van Vliet ALW, Dekker JG, van der Grein SG, Saucedo JG, Anand AA, Trellet ME, Bonvin AMJJ, Walter P, Heck AJR, de Groot RJ, and van Kuppeveld FJM

Subjects
Animals, Binding Sites, Chlorocebus aethiops, Eukaryotic Cells metabolism, Eukaryotic Initiation Factor-2 metabolism, Eukaryotic Initiation Factor-2B metabolism, Gene Knockout Techniques, HEK293 Cells, HeLa Cells, Humans, Phosphorylation, Picornaviridae metabolism, Protein Binding, Vero Cells, Eukaryotic Initiation Factor-2 antagonists & inhibitors, Eukaryotic Initiation Factor-2B antagonists & inhibitors, Stress, Physiological physiology, Viral Proteins metabolism
Abstract

Eukaryotic cells, when exposed to environmental or internal stress, activate the integrated stress response (ISR) to restore homeostasis and promote cell survival. Specific stress stimuli prompt dedicated stress kinases to phosphorylate eukaryotic initiation factor 2 (eIF2). Phosphorylated eIF2 (p-eIF2) in turn sequesters the eIF2-specific guanine exchange factor eIF2B to block eIF2 recycling, thereby halting translation initiation and reducing global protein synthesis. To circumvent stress-induced translational shutdown, viruses encode ISR antagonists. Those identified so far prevent or reverse eIF2 phosphorylation. We now describe two viral proteins-one from a coronavirus and the other from a picornavirus-that have independently acquired the ability to counteract the ISR at its very core by acting as a competitive inhibitor of p-eIF2-eIF2B interaction. This allows continued formation of the eIF2-GTP-Met-tRNAi ternary complex and unabated global translation at high p-eIF2 levels that would otherwise cause translational arrest. We conclude that eIF2 and p-eIF2 differ in their interaction with eIF2B to such effect that p-eIF2-eIF2B association can be selectively inhibited.

Published
2020
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