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Your search keyword '"van Cappellen, W."' showing total 2 results
Start Over Author "van Cappellen, W." Publisher nature publishing group
2 results on '"van Cappellen, W."'

1. Detection and imaging of atmospheric radio flashes from cosmic ray air showers

Author

Falcke, H., Apel, W. D., Badea, A. F., Bahren, L., Bekk, K., Bercuci, A., Bertaina, M., Biermann, P. L., Blumer, J., Bozdog, H., Brancus, I. M., Buitink, S., Bruggemann, M., Buchholz, P., Butcher, H., Chiavassa, A., Daumiller, K., de Bruyn, A. G., de Vos, C. M., Di Pierro, F., Doll, P., Engel, R., Gemmeke, H., Ghia, P. L., Glasstetter, R., Grupen, C., Haungs, A., Heck, D., Horandel, J. R., Horneffer, A., Huege, T., Kampert, K.-H., Kant, G. W., Klein, U., Kolotaev, Y., Koopman, Y., Kromer, O., Kuijpers, J., Lafebre, S., Maier, G., Mathes, H. J., Mayer, H. J., Milke, J., Mitrica, B., Morello, C., Navarra, G., Nehls, S., Nigl, A., Obenland, R., Oehlschlager, J., Ostapchenko, S., Over, S., Pepping, H. J., Petcu, M., Petrovic, J., Plewnia, S., Rebel, H., Risse, A., Roth, M., Schieler, H., Schoonderbeek, G., Sima, O., Stumpert, M., Toma, G., Trinchero, G. C., Ulrich, H., Valchierotti, S., van Buren, J., van Cappellen, W., Walkowiak, W., Weindl, A., Wijnholds, S., Wochele, J., Zabierowski, J., Zensus, J. A., and Zimmermann, D.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): H. Falcke (corresponding author) [1, 4, 9]; W. D. Apel [6]; A. F. Badea [6]; L. Bähren [4]; K. Bekk [6]; A. Bercuci [3]; M. Bertaina [11]; P. L. [...]

Published
2005
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2. In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium.

Author

Boisset JC, van Cappellen W, Andrieu-Soler C, Galjart N, Dzierzak E, and Robin C

Subjects
Animals, Aorta embryology, Aorta surgery, Core Binding Factor Alpha 2 Subunit deficiency, Core Binding Factor Alpha 2 Subunit genetics, Core Binding Factor Alpha 2 Subunit metabolism, Dissection, Embryo, Mammalian cytology, Endothelial Cells cytology, Endothelium, Vascular embryology, Female, Male, Mice, Microscopy, Confocal, Phenotype, Pregnancy, Aorta cytology, Cell Differentiation, Cell Lineage, Endothelium, Vascular cytology, Hematopoietic Stem Cells cytology
Abstract

Haematopoietic stem cells (HSCs), responsible for blood production in the adult mouse, are first detected in the dorsal aorta starting at embryonic day 10.5 (E10.5). Immunohistological analysis of fixed embryo sections has revealed the presence of haematopoietic cell clusters attached to the aortic endothelium where HSCs might localize. The origin of HSCs has long been controversial and several candidates of the direct HSC precursors have been proposed (for review see ref. 7), including a specialized endothelial cell population with a haemogenic potential. Such cells have been described both in vitro in the embryonic stem cell (ESC) culture system and retrospectively in vivo by endothelial lineage tracing and conditional deletion experiments. Whether the transition from haemogenic endothelium to HSC actually occurs in the mouse embryonic aorta is still unclear and requires direct and real-time in vivo observation. To address this issue we used time-lapse confocal imaging and a new dissection procedure to visualize the deeply located aorta. Here we show the dynamic de novo emergence of phenotypically defined HSCs (Sca1(+), c-kit(+), CD41(+)) directly from ventral aortic haemogenic endothelial cells.

Published
2010
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