1. Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement
- Author
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Smith, N, Pietrancosta, N, Davidson, S, Dutrieux, J, Chauveau, L, Cutolo, P, Dy, M, Scott-Algara, D, Manoury, B, Zirafi, O, McCort-Tranchepain, I, Durroux, T, Bachelerie, F, Schwartz, O, Muench, J, Wack, A, Nisole, S, Herbeuval, J-P, Smith, N, Pietrancosta, N, Davidson, S, Dutrieux, J, Chauveau, L, Cutolo, P, Dy, M, Scott-Algara, D, Manoury, B, Zirafi, O, McCort-Tranchepain, I, Durroux, T, Bachelerie, F, Schwartz, O, Muench, J, Wack, A, Nisole, S, and Herbeuval, J-P
- Abstract
Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mouse model of influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by amines to inhibit pDC. Our study establishes a functional link between natural amines and the innate immune system and identifies CXCR4 as a potential 'on-off' switch of pDC activity with therapeutic potential.
- Published
- 2017