1. Circulating MicroRNA-92b-3p as a Novel Biomarker for Monitoring of Synovial Sarcoma
- Author
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Yutaka Nezu, Suguru Yokoo, Kunihiko Numoto, Tsukasa Yonemoto, Aki Yoshida, Shintaro Iwata, Joe Hasei, Toshifumi Ozaki, Toshiyuki Kunisada, Tomohiro Fujiwara, Akira Kawai, Takeshi Ishii, Koji Uotani, Masahiro Kiyono, Ken Takeda, Takahiro Ochiya, and Takuya Morita
- Subjects
0301 basic medicine ,Adult ,Male ,Mice, Nude ,lcsh:Medicine ,Exosomes ,Article ,Diagnosis, Differential ,03 medical and health sciences ,Sarcoma, Synovial ,Young Adult ,0302 clinical medicine ,medicine ,Biomarkers, Tumor ,Tumor Cells, Cultured ,Animals ,Humans ,Clinical significance ,Circulating MicroRNA ,Liquid biopsy ,Child ,lcsh:Science ,Mice, Inbred BALB C ,Multidisciplinary ,business.industry ,lcsh:R ,Case-control study ,Sarcoma ,Middle Aged ,medicine.disease ,Synovial sarcoma ,Microvesicles ,Gene Expression Regulation, Neoplastic ,MicroRNAs ,030104 developmental biology ,030220 oncology & carcinogenesis ,Case-Control Studies ,Cancer research ,Biomarker (medicine) ,Female ,lcsh:Q ,Sarcoma, Experimental ,business - Abstract
The lack of useful biomarkers is a crucial problem for patients with soft tissue sarcomas (STSs). Emerging evidence has suggested that circulating microRNAs (miRNAs) in body fluids have novel impact as biomarkers for patients with malignant diseases, but their significance in synovial sarcoma (SS) patients remains unknown. Initial global miRNA screening using SS patient serum and SS cell culture media identified a signature of four upregulated miRNAs. Among these candidates, miR-92b-3p secretion from SS cells was confirmed, which was embedded within tumour-derived exosomes rather than argonaute-2. Animal experiments revealed a close correlation between serum miR-92b-3p levels and tumour dynamics. Clinical relevance was validated in two independent clinical cohorts, and we subsequently identified that serum miR-92b-3p levels were significantly higher in SS patients in comparison to that in healthy individuals. Moreover, serum miR-92b-3p was robust in discriminating patients with SS from the other STS patients and reflected tumour burden in SS patients. Overall, liquid biopsy using serum miR-92b-3p expression levels may represent a novel approach for monitoring tumour dynamics of SS.
- Published
- 2017