1. Corrigendum: The formation of multivesicular bodies in activated blastocysts is influenced by autophagy and FGF signaling in mice
- Author
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Ji-Yeon Kim, Hye-Jin Shin, Jin Hyun Jun, Hyunjung Jade Lim, Soyoung Bang, and Haengseok Song
- Subjects
0301 basic medicine ,Male ,Section (typography) ,macromolecular substances ,Biology ,Fibroblast growth factor ,Article ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Autophagy ,Animals ,reproductive and urinary physiology ,Multidisciplinary ,urogenital system ,Multivesicular Bodies ,Corrigenda ,Receptors, Fibroblast Growth Factor ,Cell biology ,Fibroblast Growth Factors ,030104 developmental biology ,Blastocyst ,Pyrimidines ,embryonic structures ,Female ,030217 neurology & neurosurgery ,Signal Transduction - Abstract
Dormant blastocysts during delayed implantation undergo autophagic activation, which is an adaptive response to prolonged survival in utero during less favorable environment. We observed that multivesicular bodies (MVBs) accumulate in the trophectoderm of dormant blastocysts upon activation for implantation. Since autophagosomes are shown to fuse with MVBs and efficient autophagic degradation requires functional MVBs, we examined if MVB formation in activated blastocysts are associated with protracted autophagic state during dormancy. We show here that autophagic activation during dormancy is one precondition for MVB formation in activated blastocysts. Furthermore, the blockade of FGF signaling with PD173074 partially interferes with MVB formation in these blastocysts, suggesting the involvement of FGFR signaling in this process. We believe that MVB formation in activated blastocysts after dormancy is a potential mechanism of clearing subcellular debris accumulated during prolonged autophagy.
- Published
- 2017