1. Locus Coeruleus atrophy doesn’t relate to fatigue in Parkinson’s disease
- Author
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Solopchuk, Oleg, Sebti, Moustapha, Bouvy, Céline, Benoit, Charles-Etienne, Warlop, Thibault, Jeanjean, Anne, Zénon, Alexandre, UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de médecine physique et de réadaptation motrice, UCL - (SLuc) Service de neurologie, Université Catholique de Louvain (UCL), Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), and Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Male ,Melanins ,lcsh:R ,Brain ,lcsh:Medicine ,Parkinson Disease ,Article ,[SHS]Humanities and Social Sciences ,Substantia Nigra ,Norepinephrine ,Humans ,Female ,Locus Coeruleus ,lcsh:Q ,Atrophy ,lcsh:Science ,ComputingMilieux_MISCELLANEOUS ,Fatigue - Abstract
Fatigue is a frequent complaint among healthy population and one of the earliest and most debilitating symptoms in Parkinson’s disease (PD). Earlier studies have examined the role of dopamine and serotonin in pathogenesis of fatigue, but the plausible role of noradrenalin (NA) remains underexplored. We investigated the relationship between fatigue in Parkinsonian patients and the extent of degeneration of Locus Coeruleus (LC), the main source of NA in the brain. We quantified LC and Substantia Nigra (SN) atrophy using neuromelanin-sensitive imaging, analyzed with a novel, fully automated algorithm. We also assessed patients’ fatigue, depression, sleep disturbance and vigilance. We found that LC degeneration correlated with the levels of depression and vigilance but not with fatigue, while fatigue correlated weakly with atrophy of SN. These results indicate that LC degeneration in Parkinson’s disease is unlikely to cause fatigue, but may be involved in mood and vigilance alterations.
- Published
- 2018
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