1. Helicobacter pylori Genetic Diversity and Gastro-duodenal Diseases in Malaysia
- Author
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Jamuna Vadivelu, Indran Seevasant, Hazel M. Mitchell, Khean-Lee Goh, Mun Fai Loke, Mun Hua Tan, Laurence J. Croft, and S.P. Gunaletchumy
- Subjects
medicine.medical_specialty ,Peptic Ulcer ,Molecular Sequence Data ,Chronic gastritis ,Disease ,Gastroenterology ,Article ,Helicobacter Infections ,Gastro ,Stomach Neoplasms ,Internal medicine ,Fructose-Bisphosphate Aldolase ,medicine ,Humans ,Amino Acid Sequence ,Genetic Association Studies ,Phylogeny ,Multidisciplinary ,biology ,Helicobacter pylori ,Incidence (epidemiology) ,Malaysia ,Cancer ,Genetic Variation ,medicine.disease ,biology.organism_classification ,digestive system diseases ,Duodenal Diseases ,Genes, Bacterial ,Gastritis ,medicine.symptom ,Bacterial Outer Membrane Proteins ,Multilocus Sequence Typing - Abstract
Helicobacter pylori infection results in diverse clinical conditions ranging from chronic gastritis and ulceration to gastric adenocarcinoma. Among the multiethnic population of Malaysia, Indians consistently have a higher H. pylori prevalence as compared with Chinese and Malays. Despite the high prevalence of H. pylori, Indians have a relatively low incidence of peptic ulcer disease and gastric cancer. In contrast, gastric cancer and peptic ulcer disease incidence is high in Chinese. H. pylori strains from Chinese strains predominantly belong to the hspEAsia subpopulation while Indian/Malay strains mainly belong to the hspIndia subpopulation. By comparing the genome of 27 Asian strains from different subpopulations, we identified six genes associated with risk of H. pylori-induced peptic ulcer disease and gastric cancer. This study serves as an important foundation for future studies aiming to understand the role of bacterial factors in H. pylori-induced gastro-duodenal diseases.
- Published
- 2014