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1. Mapping routine measles vaccination in low- and middle-income countries

Author

Sbarra, AN, Rolfe, S, Nguyen, JQ, Earl, L, Galles, NC, Marks, A, Abbas, KM, Abbasi-Kangevari, M, Abbastabar, H, Abd-Allah, F, Abdelalim, A, Abdollahi, M, Abegaz, KH, Abiy, HAA, Abolhassani, H, Abreu, LG, Abrigo, MRM, Abushouk, AI, Accrombessi, MMK, Adabi, M, Adebayo, OM, Adekanmbi, V, Adetokunboh, OO, Adham, D, Afarideh, M, Aghaali, M, Ahmad, T, Ahmadi, R, Ahmadi, K, Ahmed, MB, Alanezi, FM, Alanzi, TM, Alcalde-Rabanal, JE, Alemnew, BT, Ali, BA, Ali, M, Alijanzadeh, M, Alinia, C, Alipoor, R, Alipour, V, Alizade, H, Aljunid, SM, Almasi, A, Almasi-Hashiani, A, Al-Mekhlafi, HM, Altirkawi, KA, Amare, B, Amini, S, Amini-Rarani, M, Amiri, F, Amit, AML, Amugsi, DA, Ancuceanu, R, Andrei, CL, Anjomshoa, M, Ansari, F, Ansari-Moghaddam, A, Ansha, MG, Antonio, CAT, Antriyandarti, E, Anvari, D, Arabloo, J, Arab-Zozani, M, Aremu, O, Armoon, B, Aryal, KK, Arzani, A, Asadi-Aliabadi, M, Asgari, S, Atafar, Z, Ausloos, M, Awoke, N, Quintanilla, BPA, Ayanore, MA, Aynalem, YA, Azadmehr, A, Azari, S, Babaee, E, Badawi, A, Badiye, AD, Bahrami, MA, Baig, AA, Bakhtiari, A, Balakrishnan, S, Banach, M, Banik, PC, Barac, A, Baradaran-Seyed, Z, Baraki, AG, Basu, S, Bayati, M, Bayou, YT, Bedi, N, Behzadifar, M, Bell, ML, Berbada, DA, Berhe, K, Bhattarai, S, Bhutta, ZA, Bijani, A, Birhanu, M, Bisanzio, D, Biswas, A, Bohlouli, S, Bolla, SR, Borzouei, S, Brady, OJ, Bragazzi, NL, Briko, AN, Briko, NI, Nagaraja, SB, Butt, ZA, Cámera, LA, Campos-Nonato, IR, Car, J, Cárdenas, R, Carvalho, F, Castaldelli-Maia, JM, Castro, F, Chattu, VK, Chehrazi, M, Chin, KL, Chu, D-T, Cook, AJ, Cormier, NM, Cunningham, B, Dahlawi, SMA, Damiani, G, Dandona, R, Dandona, L, Danovaro, MC, Dansereau, E, Daoud, F, Darwesh, AM, Darwish, AH, Das, JK, Weaver, ND, De Neve, J-W, Demeke, FM, Demis, AB, Denova-Gutiérrez, E, Desalew, A, Deshpande, A, Desta, DM, Dharmaratne, SD, Dhungana, GP, Dianatinasab, M, Diaz, D, Dipeolu, IO, Djalalinia, S, Do, HT, Dorostkar, F, Doshmangir, L, Doyle, KE, Dunachie, SJ, Duraes, AR, Kalan, ME, Leylabadlo, HE, Edinur, HA, Effiong, A, Eftekhari, A, El, Sayed, I, El, Sayed, Zaki, M, Elema, TB, Elhabashy, HR, El-Jaafary, SI, Elsharkawy, A, Emamian, MH, Enany, S, Eshrati, B, Eskandari, K, Eskandarieh, S, Esmaeilnejad, S, Esmaeilzadeh, F, Esteghamati, A, Etisso, AE, Farahmand, M, Faraon, EJA, Fareed, M, Faridnia, R, Farioli, A, Farzadfar, F, Fattahi, N, Fazlzadeh, M, Fereshtehnejad, S-M, Fernandes, E, Filip, I, Fischer, F, Foigt, NA, Folayan, MO, Foroutan, M, Fukumoto, T, Fullman, N, Gad, MM, Geberemariyam, BS, Gebrehiwot, TT, Gebrehiwot, AM, Gebremariam, KT, Gebremedhin, KB, Gebremeskel, GG, Gebreslassie, AA, Gedefaw, GA, Gezae, KE, Ghadiri, K, Ghaffari, R, Ghaffarifar, F, Ghajarzadeh, M, Gheshlagh, RG, Ghashghaee, A, Ghiasvand, H, Gholamian, A, Gilani, SA, Gill, PS, Girmay, A, Gomes, NGM, Gopalani, SV, Goulart, BNG, Grada, A, Guimarães, RA, Guo, Y, Gupta, R, Hafezi-Nejad, N, Haj-Mirzaian, A, Handiso, DW, Hanif, A, Haririan, H, Hasaballah, AI, Hasan, MM, Hasanpoor, E, Hasanzadeh, A, Hassanipour, S, Hassankhani, H, Heidari-Soureshjani, R, Henry, NJ, Herteliu, C, Heydarpour, F, Hollerich, GI, Rad, EH, Hoogar, P, Hossain, N, Hosseini, M, Hosseinzadeh, M, Househ, M, Hu, G, Huda, TM, Humayun, A, Ibitoye, SE, Ikilezi, G, Ilesanmi, OS, Ilic, IM, Ilic, MD, Imani-Nasab, MH, Inbaraj, LR, Iqbal, U, Irvani, SSN, Islam, SMS, Islam, MM, Iwu, CJ, Iwu, CCD, Jadidi-Niaragh, F, Jafarinia, M, Jahanmehr, N, Jakovljevic, M, Jalali, A, Jalilian, F, Javidnia, J, Jenabi, E, Jha, V, Ji, JS, John, O, Johnson, KB, Joukar, F, Jozwiak, JJ, Kabir, Z, Kabir, A, Kalani, H, Kalankesh, LR, Kalhor, R, Kamal, Z, Kanchan, T, Kapoor, N, Karami, M, Matin, BK, Karch, A, Karimi, SE, Kayode, GA, Karyani, AK, Keiyoro, PN, Khader, YS, Khafaie, MA, Khammarnia, M, Khan, MS, Khan, EA, Khan, J, Khan, MN, Khatab, K, Khater, MM, Khatib, MN, Khayamzadeh, M, Khazaei, M, Khazaei, S, Khosravi, A, Khubchandani, J, Kianipour, N, Kim, YJ, Kimokoti, RW, Kinyoki, DK, Kisa, A, Kisa, S, Kolola, T, Komaki, H, Kosen, S, Koul, PA, Koyanagi, A, Kraemer, MUG, Krishan, K, Kuate Defo, B, Kumar, M, Kumar, P, Kumar, GA, Kusuma, D, La Vecchia, C, Lacey, B, Lad, SD, Lal, DK, Lam, F, Lami, FH, Lansingh, VC, Larson, HJ, Lasrado, S, Lee, SWH, Lee, PH, LeGrand, KE, Lenjebo, TL, Li, S, Liang, X, Liu, PY, Lopukhov, PD, Machado, DB, Mahasha, PW, Mahdavi, MM, Maheri, M, Mahotra, NB, Maled, V, Maleki, S, Malik, MA, Malta, DC, Mansour-Ghanaei, F, Mansouri, B, Mansourian, M, Mansournia, MA, Martins-Melo, FR, Masaka, A, Mayala, BK, Mehndiratta, MM, Mehri, F, Mehta, KM, Memiah, PTN, Mendoza, W, Menezes, RG, Mengesha, MB, Mengesha, EW, Mestrovic, T, Mihretie, KM, Miller-Petrie, MK, Mills, EJ, Milne, GJ, Mirabi, P, Mirrakhimov, EM, Mirzaei, R, Mirzaei, M, Mirzaei, HR, Mirzaei, H, Mirzaei-Alavijeh, M, Moazen, B, Moghadaszadeh, M, Mohamadi, E, Mohammad, DK, Mohammad, Y, Mohammad, KA, Mohammad Gholi Mezerji, N, Mohammadbeigi, A, Mohammadian-Hafshejani, A, Mohammadpourhodki, R, Mohammed, S, Mohammed, AS, Mohammed, H, Mohebi, F, Mokdad, AH, Monasta, L, Moosavi, MA, Moosazadeh, M, Moradi, G, Moradi, M, Moradi-Joo, M, Moradi-Lakeh, M, Moradzadeh, R, Moraga, P, Mosapour, A, Mouodi, S, Mousavi, SM, Khaneghah, AM, Mueller, UO, Muluneh, AG, Munro, SB, Murray, CJL, Murthy, GVS, Muthupandian, S, Naderi, M, Nagarajan, AJ, Naghavi, M, Nangia, V, Nansseu, JR, Nayak, VC, Nazari, J, Ndwandwe, DE, Negoi, I, Ngunjiri, JW, Nguyen, HLT, Nguyen, CTK, Nguyen, TH, Nigatu, YT, Nikbakhsh, R, Nikfar, S, Nikpoor, AR, Ningrum, DNA, Nnaji, CA, Oh, I-H, Oladnabi, M, Olagunju, AT, Olusanya, JO, Olusanya, BO, Bali, AO, Omer, MO, Onwujekwe, OE, Osgood-Zimmerman, AE, Owolabi, MO, P, A, M, Padubidri, JR, Pakshir, K, Pana, A, Pandey, A, Pando-Robles, V, Pashaei, T, Pasupula, DK, Paternina-Caicedo, AJ, Patton, GC, Pazoki Toroudi, H, Pepito, VCF, Pescarini, JM, Pigott, DM, Pilgrim, T, Pirsaheb, M, Poljak, M, Postma, MJ, Pourjafar, H, Pourmalek, F, Pourmirza, Kalhori, R, Prada, SI, Prakash, S, Quazi Syed, Z, Quintana, H, Rabiee, N, Rabiee, M, Radfar, A, Rafiei, A, Rahim, F, Rajati, F, Rameto, MA, Ramezanzadeh, K, Ranabhat, CL, Rao, SJ, Rasella, D, Rastogi, P, Rathi, P, Rawaf, S, Rawaf, DL, Rawal, L, Rawassizadeh, R, Rawat, R, Renjith, V, Renzaho, AMN, Reshmi, B, Reta, MA, Rezaei, N, Rezai, MS, Rezapour, A, Riahi, SM, Ribeiro, AI, Rickard, J, Rios-Blancas, M, Rios-González, CM, Roever, L, Rostamian, M, Rubino, S, Rwegerera, GM, Saad, AM, Saadatagah, S, Sabour, S, Sadeghi, E, Moghaddam, SS, Saeidi, S, Sagar, R, Sahebkar, A, Sahraian, MA, Sajadi, SM, Salahshoor, MR, Salam, N, Salem, H, Salem, MR, Salomon, JA, Kafil, HS, Sambala, EZ, Samy, AM, Saraswathy, SYI, Sarmiento-Suárez, R, Saroshe, S, Sartorius, B, Sarveazad, A, Sathian, B, Sathish, T, Schaeffer, LE, Schwebel, DC, Senthilkumaran, S, Shabaninejad, H, Shahabi, S, Shaheen, AA, Shaikh, MA, Shalash, AS, Shams-Beyranvand, M, Shamsi, MB, Shamsizadeh, M, Sharafi, K, Sharifi, H, Sheikh, A, Sheikhtaheri, A, Shetty, RS, Shiferaw, WS, Shigematsu, M, Shin, JI, Shirkoohi, R, Siabani, S, Siddiqi, TJ, Silverberg, JIS, Simonetti, B, Singh, JA, Sinha, DN, Sinke, AH, Soheili, A, Sokhan, A, Soltani, S, Soofi, M, Sorrie, MB, Soyiri, IN, Spotin, A, Spurlock, EE, Sreeramareddy, CT, Sudaryanto, A, Sufiyan, MB, Suleria, HAR, Abdulkader, RS, Taherkhani, A, Tapak, L, Taveira, N, Taymoori, P, Tefera, YM, Tehrani-Banihashemi, A, Teklehaimanot, BF, Tekulu, GH, Tesfay, BE, Tessema, ZT, Tessema, B, Thankappan, KR, Tohidinik, HR, Topor-Madry, R, Tovani-Palone, MR, Tran, BX, Uddin, R, Ullah, I, Umeokonkwo, CD, Unnikrishnan, B, Upadhyay, E, Usman, MS, Vaezi, M, Valadan, Tahbaz, S, Valdez, PR, Vasseghian, Y, Veisani, Y, Violante, FS, Vollmer, S, Waheed, Y, Wakefield, J, Wang, Y, Wang, Y-P, Weldesamuel, GT, Werdecker, A, Westerman, R, Wiangkham, T, Wiens, KE, Wiysonge, CS, Woldu, G, Wondafrash, DZ, Wonde, TE, Wu, A-M, Yadollahpour, A, Jabbari, SHY, Yamada, T, Yaya, S, Yazdi-Feyzabadi, V, Yeheyis, TY, Yeshaw, Y, Yilgwan, CS, Yip, P, Yonemoto, N, Younis, MZ, Yousefi, Z, Yousefifard, M, Yousefinezhadi, T, Yu, C, Yusefzadeh, H, Zadey, S, Zahirian, Moghadam, T, Zaki, L, Zaman, SB, Zamani, M, Zamanian, M, Zandian, H, Zangeneh, A, Zarei, F, Zerfu, TA, Zhang, Y, Zhang, Z-J, Zhao, X-JG, Zhou, M, Ziapour, A, Hay, SI, Lim, SS, Mosser, JF, Local Burden of Disease Vaccine Coverage Collaborators, Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Value, Affordability and Sustainability (VALUE), Microbes in Health and Disease (MHD), HUS Comprehensive Cancer Center, Clinicum, Department of Oncology, Sbarra, Alyssa N., Rolfe, Sam, Nguyen, Jason Q., Earl, Lucas, Ahmed, MB, Mosser, Jonathan F, Collaborators, Local Burden of Disease Vaccine Coverage, Bill & Melinda Gates Foundation, Alexander von Humboldt-Stiftung, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Universiti Sains Malaysia (Malasia), Panjab University (India), NIHR - Oxford Biomedical Research Centre (Reino Unido), Australian Research Council, Instituto de Saúde Pública da Universidade do Porto, Local Burden Dis Educ Attainment C, Local Burden of Disease Vaccine Coverage Collaborator, and Violante FS

Subjects
and promotion of well-being, Vacunación Masiva, Internationality, Disease prevention, children under 5 years old, Geographic Mapping, Rural Health, medicine.disease_cause, Cross-reactivity, 0302 clinical medicine, RA0421, Vaccination Refusal, 030212 general & internal medicine, Child, immunity patterns, Pediatric, 0303 health sciences, Public health, Multidisciplinary, biology, Vaccination, Uncertainty, IMMUNIZATION, 3142 Public health care science, environmental and occupational health, COVERAGE, 3. Good health, TIME, 3.4 Vaccines, Child, Preschool, Infectious diseases, A990 Medicine and Dentistry not elsewhere classified, Antibody, Engineering sciences. Technology, AFRICA, General Science & Technology, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19, 610 Medicine & health, Global Vaccine Action Plan (GVAP), Local Burden of Disease Vaccine Coverage Collaborators, Article, Vaccine Related, 03 medical and health sciences, measles vaccine, Measels, Low- and middle-income countries, Local burden of disease, Clinical Research, medicine, Humans, Healthcare Disparities, Preschool, PROGRESS, 030304 developmental biology, business.industry, MORTALITY, Developed Countries, Prevention, Comment, Vacunación, Urban Health, Prevention of disease and conditions, Virology, Coronavirus, Good Health and Well Being, Cobertura de Vacunación, biology.protein, Immunization, business, Measles
Abstract

The safe, highly effective measles vaccine has been recommended globally since 1974, yet in 2017 there were more than 17 million cases of measles and 83,400 deaths in children under 5 years old, and more than 99% of both occurred in low- and middle-income countries (LMICs)1–4. Globally comparable, annual, local estimates of routine first-dose measles-containing vaccine (MCV1) coverage are critical for understanding geographically precise immunity patterns, progress towards the targets of the Global Vaccine Action Plan (GVAP), and high-risk areas amid disruptions to vaccination programmes caused by coronavirus disease 2019 (COVID-19)5–8. Here we generated annual estimates of routine childhood MCV1 coverage at 5 × 5-km2 pixel and second administrative levels from 2000 to 2019 in 101 LMICs, quantified geographical inequality and assessed vaccination status by geographical remoteness. After widespread MCV1 gains from 2000 to 2010, coverage regressed in more than half of the districts between 2010 and 2019, leaving many LMICs far from the GVAP goal of 80% coverage in all districts by 2019. MCV1 coverage was lower in rural than in urban locations, although a larger proportion of unvaccinated children overall lived in urban locations; strategies to provide essential vaccination services should address both geographical contexts. These results provide a tool for decision-makers to strengthen routine MCV1 immunization programmes and provide equitable disease protection for all children., Although progress in the coverage of routine measles vaccination in children in low- and middle-income countries was made during 2000–2019, many countries remain far from the goal of 80% coverage in all districts by 2019.

Published
2021

2. Mapping 123 million neonatal, infant and child deaths between 2000 and 2017

Author

Burstein, R., Henry, N. J., Collison, M. L., Marczak, L. B., Sligar, A., Watson, S., Marquez, N., Abbasalizad-Farhangi, M., Abbasi, M., Abd-Allah, F., Abdoli, A., Abdollahi, M., Abdollahpour, I., Abdulkader, R. S., Abrigo, M. R. M., Acharya, D., Adebayo, O. M., Adekanmbi, V., Adham, D., Afshari, M., Aghaali, M., Ahmadi, K., Ahmadi, M., Ahmadpour, E., Ahmed, R., Akal, C. G., Akinyemi, J. O., Alahdab, F., Alam, N., Alamene, G. M., Alene, K. A., Alijanzadeh, M., Alinia, C., Alipour, V., Aljunid, S. M., Almalki, M. J., Al-Mekhlafi, H. M., Altirkawi, K., Alvis-Guzman, N., Amegah, A. K., Amini, S., Amit, A. M. L., Anbari, Z., Androudi, S., Anjomshoa, M., Ansari, F., Antonio, C. A. T., Arabloo, J., Arefi, Z., Aremu, O., Armoon, B., Arora, A., Artaman, A., Asadi, A., Asadi-Aliabadi, M., Ashraf-Ganjouei, A., Assadi, R., Ataeinia, B., Atre, S. R., Quintanilla, B. P. A., Ayanore, M. A., Azari, S., Babaee, E., Babazadeh, A., Badawi, A., Bagheri, S., Bagherzadeh, M., Baheiraei, N., Balouchi, A., Barac, A., Bassat, Q., Baune, B. T., Bayati, M., Bedi, N., Beghi, E., Behzadifar, M., Belay, Y. B., Bell, B., Bell, M. L., Berbada, D. A., Bernstein, R. S., Bhattacharjee, N. V., Bhattarai, S., Bhutta, Z. A., Bijani, A., Bohlouli, S., Breitborde, N. J. K., Britton, G., Browne, A. J., Nagaraja, S. B., Busse, R., Butt, Z. A., Car, J., Cárdenas, R., Castañeda-Orjuela, C. A., Cerin, E., Chanie, W. F., Chatterjee, P., Chu, D. -T, Cooper, C., Costa, V. M., Dalal, Koustuv, Dandona, L., Dandona, R., Daoud, F., Daryani, A., Das Gupta, R., Davis, I., Davis Weaver, N., Davitoiu, D. V., De Neve, J. -W, Demeke, F. M., Demoz, G. T., Deribe, K., Desai, R., Deshpande, A., Desyibelew, H. D., Dey, S., Dharmaratne, S. D., Dhimal, M., Diaz, D., Doshmangir, L., Duraes, A. R., Dwyer-Lindgren, L., Earl, L., Ebrahimi, R., Ebrahimpour, S., Effiong, A., Eftekhari, A., Ehsani-Chimeh, E., El Sayed, I., El Sayed Zaki, M., El Tantawi, M., El-Khatib, Z., Emamian, M. H., Enany, S., Eskandarieh, S., Eyawo, O., Ezalarab, M., Faramarzi, M., Fareed, M., Faridnia, R., Faro, A., Fazaeli, A. A., Fazlzadeh, M., Fentahun, N., Fereshtehnejad, S. -M, Fernandes, J. C., Filip, I., Fischer, F., Foigt, N. A., Foroutan, M., Francis, J. M., Fukumoto, T., Fullman, N., Gallus, S., Gebre, D. G., Gebrehiwot, T. T., Gebremeskel, G. G., Gessner, B. D., Geta, B., Gething, P. W., Ghadimi, R., Ghadiri, K., Ghajarzadeh, M., Ghashghaee, A., Gill, P. S., Gill, T. K., Golding, N., Gomes, N. G. M., Gona, P. N., Gopalani, S. V., Gorini, G., Goulart, B. N. G., Graetz, N., Greaves, F., Green, M. S., Guo, Y., Haj-Mirzaian, A., Hall, B. J., Hamidi, S., Haririan, H., Haro, J. M., Hasankhani, M., Hasanpoor, E., Hasanzadeh, A., Hassankhani, H., Hassen, H. Y., Hegazy, M. I., Hendrie, D., Heydarpour, F., Hird, T. R., Hoang, C. L., Hollerich, G., Rad, E. H., Hoseini-Ghahfarokhi, M., Hossain, N., Hosseini, M., Hosseinzadeh, M., Hostiuc, M., Hostiuc, S., Househ, M., Hsairi, M., Ilesanmi, O. S., Imani-Nasab, M. H., Iqbal, U., Irvani, S. S. N., Islam, N., Islam, S. M. S., JÌrisson, M., Balalami, N. J., Jalali, A., Javidnia, J., Jayatilleke, A. U., Jenabi, E., Ji, J. S., Jobanputra, Y. B., Johnson, K., Jonas, J. B., Shushtari, Z. J., Jozwiak, J. J., Kabir, A., Kahsay, A., Kalani, H., Kalhor, R., Karami, M., Karki, S., Kasaeian, A., Kassebaum, N. J., Keiyoro, P. N., Kemp, G. R., Khabiri, R., Khader, Y. S., Khafaie, M. A., Khan, E. A., Khan, J., Khan, M. S., Khang, Y. -H, Khatab, K., Khater, A., Khater, M. M., Khatony, A., Khazaei, M., Khazaei, S., Khazaei-Pool, M., Khubchandani, J., Kianipour, N., Kim, Y. J., Kimokoti, R. W., Kinyoki, D. K., Kisa, A., Kisa, S., Kolola, T., Kosen, S., Koul, P. A., Koyanagi, A., Kraemer, M. U. G., Krishan, K., Krohn, K. J., Kugbey, N., Kumar, G. A., Kumar, M., Kumar, P., Kuupiel, D., Lacey, B., Lad, S. D., Lami, F. H., Larsson, A. O., Lee, P. H., Leili, M., Levine, A. J., Li, S., Lim, L. -L, Listl, S., Longbottom, J., Lopez, J. C. F., Lorkowski, S., Magdeldin, S., Abd El Razek, H. M., Abd El Razek, M. M., Majeed, A., Maleki, A., Malekzadeh, R., Malta, D. C., Mamun, A. A., Manafi, N., Manda, A. -L, Mansourian, M., Martins-Melo, F. R., Masaka, A., Massenburg, B. B., Maulik, P. K., Mayala, B. K., Mazidi, M., McKee, M., Mehrotra, R., Mehta, K. M., Meles, G. G., Mendoza, W., Menezes, R. G., Meretoja, A., Meretoja, T. J., Mestrovic, T., Miller, T. R., Miller-Petrie, M. K., Mills, E. J., Milne, G. J., Mini, G. K., Mir, S. M., Mirjalali, H., Mirrakhimov, E. M., Mohamadi, E., Mohammad, D. K., Darwesh, A. M., Mezerji, N. M. G., Mohammed, A. S., Mohammed, S., Mokdad, A. H., Molokhia, M., Monasta, L., Moodley, Y., Moosazadeh, M., Moradi, G., Moradi, M., Moradi, Y., Moradi-Lakeh, M., Moradinazar, M., Moraga, P., Morawska, L., Mosapour, A., Mousavi, S. M., Mueller, U. O., Muluneh, A. G., Mustafa, G., Nabavizadeh, B., Naderi, M., Nagarajan, A. J., Nahvijou, A., Najafi, F., Nangia, V., Ndwandwe, D. E., Neamati, N., Negoi, I., Negoi, R. I., Ngunjiri, J. W., Thi Nguyen, H. L., Nguyen, L. H., Nguyen, S. H., Nielsen, K. R., Ningrum, D. N. A., Nirayo, Y. L., Nixon, M. R., Nnaji, C. A., Nojomi, M., Noroozi, M., Nosratnejad, S., Noubiap, J. J., Motlagh, S. N., Ofori-Asenso, R., Ogbo, F. A., Oladimeji, K. E., Olagunju, A. T., Olfatifar, M., Olum, S., Olusanya, B. O., Oluwasanu, M. M., Onwujekwe, O. E., Oren, E., Ortega-Altamirano, D. D. V., Ortiz, A., Osarenotor, O., Osei, F. B., Osgood-Zimmerman, A. E., Otstavnov, S. S., Owolabi, M. O., Mahesh, P. A., Pagheh, A. S., Pakhale, S., Panda-Jonas, S., Pandey, A., Park, E. -K, Parsian, H., Pashaei, T., Patel, S. K., Pepito, V. C. F., Pereira, A., Perkins, S., Pickering, B. V., Pilgrim, T., Pirestani, M., Piroozi, B., Pirsaheb, M., Plana-Ripoll, O., Pourjafar, H., Puri, P., Qorbani, M., Quintana, H., Rabiee, M., Rabiee, N., Radfar, A., Rafiei, A., Rahim, F., Rahimi, Z., Rahimi-Movaghar, V., Rahimzadeh, S., Rajati, F., Raju, S. B., Ramezankhani, A., Ranabhat, C. L., Rasella, D., Rashedi, V., Rawal, L., Reiner Jr, R. C., Renzaho, A. M. N., Rezaei, S., Rezapour, A., Riahi, S. M., Ribeiro, A. I., Roever, L., Roro, E. M., Roser, M., Roshandel, G., Roshani, D., Rostami, A., Rubagotti, E., Rubino, S., Sabour, S., Sadat, N., Sadeghi, E., Saeedi, R., Safari, Y., Safari-Faramani, R., Safdarian, M., Sahebkar, A., Salahshoor, M. R., Salam, N., Salamati, P., Salehi, F., Zahabi, S. S., Salimi, Y., Salimzadeh, H., Salomon, J. A., Sambala, E. Z., Samy, A. M., Santric Milicevic, M. M., Jose, B. P. S., Saraswathy, S. Y. I., Sarmiento-Suárez, R., Sartorius, B., Sathian, B., Saxena, S., Sbarra, A. N., Schaeffer, L. E., Schwebel, D. C., Sepanlou, S. G., Seyedmousavi, S., Shaahmadi, F., Shaikh, M. A., Shams-Beyranvand, M., Shamshirian, A., Shamsizadeh, M., Sharafi, K., Sharif, M., Sharif-Alhoseini, M., Sharifi, H., Sharma, J., Sharma, R., Sheikh, A., Shields, C., Shigematsu, M., Shiri, R., Shiue, I., Shuval, K., Siddiqi, T. J., Silva, J. P., Singh, J. A., Sinha, D. N., Sisay, M. M., Sisay, S., Sliwa, K., Smith, D. L., Somayaji, R., Soofi, M., Soriano, J. B., Sreeramareddy, C. T., Sudaryanto, A., Sufiyan, M. B., Sykes, B. L., Sylaja, P. N., Tabarés-Seisdedos, R., Tabb, K. M., Tabuchi, T., Taveira, N., Temsah, M. -H, Terkawi, A. S., Tessema, Z. T., Thankappan, K. R., Thirunavukkarasu, S., To, Q. G., Tovani-Palone, M. R., Tran, B. X., Tran, K. B., Ullah, I., Usman, M. S., Uthman, O. A., Vahedian-Azimi, A., Valdez, P. R., van Boven, J. F. M., Vasankari, T. J., Vasseghian, Y., Veisani, Y., Venketasubramanian, N., Violante, F. S., Vladimirov, S. K., Vlassov, V., Vos, T., Vu, G. T., Vujcic, I. S., Waheed, Y., Wakefield, J., Wang, H., Wang, Y., Wang, Y. -P, Ward, J. L., Weintraub, R. G., Weldegwergs, K. G., Weldesamuel, G. T., Westerman, R., Wiysonge, C. S., Wondafrash, D. Z., Woyczynski, L., Wu, A. -M, Xu, G., Yadegar, A., Yamada, T., Yazdi-Feyzabadi, V., Yilgwan, C. S., Yip, P., Yonemoto, N., Lebni, J. Y., Younis, M. Z., Yousefifard, M., Yousof, H. -AS. A., Yu, C., Yusefzadeh, H., Zabeh, E., Moghadam, T. Z., Bin Zaman, S., Zamani, M., Zandian, H., Zangeneh, A., Zerfu, T. A., Zhang, Y., Ziapour, A., Zodpey, S., Murray, C. J. L., Hay, S. I., Burstein, R., Henry, N. J., Collison, M. L., Marczak, L. B., Sligar, A., Watson, S., Marquez, N., Abbasalizad-Farhangi, M., Abbasi, M., Abd-Allah, F., Abdoli, A., Abdollahi, M., Abdollahpour, I., Abdulkader, R. S., Abrigo, M. R. M., Acharya, D., Adebayo, O. M., Adekanmbi, V., Adham, D., Afshari, M., Aghaali, M., Ahmadi, K., Ahmadi, M., Ahmadpour, E., Ahmed, R., Akal, C. G., Akinyemi, J. O., Alahdab, F., Alam, N., Alamene, G. M., Alene, K. A., Alijanzadeh, M., Alinia, C., Alipour, V., Aljunid, S. M., Almalki, M. J., Al-Mekhlafi, H. M., Altirkawi, K., Alvis-Guzman, N., Amegah, A. K., Amini, S., Amit, A. M. L., Anbari, Z., Androudi, S., Anjomshoa, M., Ansari, F., Antonio, C. A. T., Arabloo, J., Arefi, Z., Aremu, O., Armoon, B., Arora, A., Artaman, A., Asadi, A., Asadi-Aliabadi, M., Ashraf-Ganjouei, A., Assadi, R., Ataeinia, B., Atre, S. R., Quintanilla, B. P. A., Ayanore, M. A., Azari, S., Babaee, E., Babazadeh, A., Badawi, A., Bagheri, S., Bagherzadeh, M., Baheiraei, N., Balouchi, A., Barac, A., Bassat, Q., Baune, B. T., Bayati, M., Bedi, N., Beghi, E., Behzadifar, M., Belay, Y. B., Bell, B., Bell, M. L., Berbada, D. A., Bernstein, R. S., Bhattacharjee, N. V., Bhattarai, S., Bhutta, Z. A., Bijani, A., Bohlouli, S., Breitborde, N. J. K., Britton, G., Browne, A. J., Nagaraja, S. B., Busse, R., Butt, Z. A., Car, J., Cárdenas, R., Castañeda-Orjuela, C. A., Cerin, E., Chanie, W. F., Chatterjee, P., Chu, D. -T, Cooper, C., Costa, V. M., Dalal, Koustuv, Dandona, L., Dandona, R., Daoud, F., Daryani, A., Das Gupta, R., Davis, I., Davis Weaver, N., Davitoiu, D. V., De Neve, J. -W, Demeke, F. M., Demoz, G. T., Deribe, K., Desai, R., Deshpande, A., Desyibelew, H. D., Dey, S., Dharmaratne, S. D., Dhimal, M., Diaz, D., Doshmangir, L., Duraes, A. R., Dwyer-Lindgren, L., Earl, L., Ebrahimi, R., Ebrahimpour, S., Effiong, A., Eftekhari, A., Ehsani-Chimeh, E., El Sayed, I., El Sayed Zaki, M., El Tantawi, M., El-Khatib, Z., Emamian, M. H., Enany, S., Eskandarieh, S., Eyawo, O., Ezalarab, M., Faramarzi, M., Fareed, M., Faridnia, R., Faro, A., Fazaeli, A. A., Fazlzadeh, M., Fentahun, N., Fereshtehnejad, S. -M, Fernandes, J. C., Filip, I., Fischer, F., Foigt, N. A., Foroutan, M., Francis, J. M., Fukumoto, T., Fullman, N., Gallus, S., Gebre, D. G., Gebrehiwot, T. T., Gebremeskel, G. G., Gessner, B. D., Geta, B., Gething, P. W., Ghadimi, R., Ghadiri, K., Ghajarzadeh, M., Ghashghaee, A., Gill, P. S., Gill, T. K., Golding, N., Gomes, N. G. M., Gona, P. N., Gopalani, S. V., Gorini, G., Goulart, B. N. G., Graetz, N., Greaves, F., Green, M. S., Guo, Y., Haj-Mirzaian, A., Hall, B. J., Hamidi, S., Haririan, H., Haro, J. M., Hasankhani, M., Hasanpoor, E., Hasanzadeh, A., Hassankhani, H., Hassen, H. Y., Hegazy, M. I., Hendrie, D., Heydarpour, F., Hird, T. R., Hoang, C. L., Hollerich, G., Rad, E. H., Hoseini-Ghahfarokhi, M., Hossain, N., Hosseini, M., Hosseinzadeh, M., Hostiuc, M., Hostiuc, S., Househ, M., Hsairi, M., Ilesanmi, O. S., Imani-Nasab, M. H., Iqbal, U., Irvani, S. S. N., Islam, N., Islam, S. M. S., JÌrisson, M., Balalami, N. J., Jalali, A., Javidnia, J., Jayatilleke, A. U., Jenabi, E., Ji, J. S., Jobanputra, Y. B., Johnson, K., Jonas, J. B., Shushtari, Z. J., Jozwiak, J. J., Kabir, A., Kahsay, A., Kalani, H., Kalhor, R., Karami, M., Karki, S., Kasaeian, A., Kassebaum, N. J., Keiyoro, P. N., Kemp, G. R., Khabiri, R., Khader, Y. S., Khafaie, M. A., Khan, E. A., Khan, J., Khan, M. S., Khang, Y. -H, Khatab, K., Khater, A., Khater, M. M., Khatony, A., Khazaei, M., Khazaei, S., Khazaei-Pool, M., Khubchandani, J., Kianipour, N., Kim, Y. J., Kimokoti, R. W., Kinyoki, D. K., Kisa, A., Kisa, S., Kolola, T., Kosen, S., Koul, P. A., Koyanagi, A., Kraemer, M. U. G., Krishan, K., Krohn, K. J., Kugbey, N., Kumar, G. A., Kumar, M., Kumar, P., Kuupiel, D., Lacey, B., Lad, S. D., Lami, F. H., Larsson, A. O., Lee, P. H., Leili, M., Levine, A. J., Li, S., Lim, L. -L, Listl, S., Longbottom, J., Lopez, J. C. F., Lorkowski, S., Magdeldin, S., Abd El Razek, H. M., Abd El Razek, M. M., Majeed, A., Maleki, A., Malekzadeh, R., Malta, D. C., Mamun, A. A., Manafi, N., Manda, A. -L, Mansourian, M., Martins-Melo, F. R., Masaka, A., Massenburg, B. B., Maulik, P. K., Mayala, B. K., Mazidi, M., McKee, M., Mehrotra, R., Mehta, K. M., Meles, G. G., Mendoza, W., Menezes, R. G., Meretoja, A., Meretoja, T. J., Mestrovic, T., Miller, T. R., Miller-Petrie, M. K., Mills, E. J., Milne, G. J., Mini, G. K., Mir, S. M., Mirjalali, H., Mirrakhimov, E. M., Mohamadi, E., Mohammad, D. K., Darwesh, A. M., Mezerji, N. M. G., Mohammed, A. S., Mohammed, S., Mokdad, A. H., Molokhia, M., Monasta, L., Moodley, Y., Moosazadeh, M., Moradi, G., Moradi, M., Moradi, Y., Moradi-Lakeh, M., Moradinazar, M., Moraga, P., Morawska, L., Mosapour, A., Mousavi, S. M., Mueller, U. O., Muluneh, A. G., Mustafa, G., Nabavizadeh, B., Naderi, M., Nagarajan, A. J., Nahvijou, A., Najafi, F., Nangia, V., Ndwandwe, D. E., Neamati, N., Negoi, I., Negoi, R. I., Ngunjiri, J. W., Thi Nguyen, H. L., Nguyen, L. H., Nguyen, S. H., Nielsen, K. R., Ningrum, D. N. A., Nirayo, Y. L., Nixon, M. R., Nnaji, C. A., Nojomi, M., Noroozi, M., Nosratnejad, S., Noubiap, J. J., Motlagh, S. N., Ofori-Asenso, R., Ogbo, F. A., Oladimeji, K. E., Olagunju, A. T., Olfatifar, M., Olum, S., Olusanya, B. O., Oluwasanu, M. M., Onwujekwe, O. E., Oren, E., Ortega-Altamirano, D. D. V., Ortiz, A., Osarenotor, O., Osei, F. B., Osgood-Zimmerman, A. E., Otstavnov, S. S., Owolabi, M. O., Mahesh, P. A., Pagheh, A. S., Pakhale, S., Panda-Jonas, S., Pandey, A., Park, E. -K, Parsian, H., Pashaei, T., Patel, S. K., Pepito, V. C. F., Pereira, A., Perkins, S., Pickering, B. V., Pilgrim, T., Pirestani, M., Piroozi, B., Pirsaheb, M., Plana-Ripoll, O., Pourjafar, H., Puri, P., Qorbani, M., Quintana, H., Rabiee, M., Rabiee, N., Radfar, A., Rafiei, A., Rahim, F., Rahimi, Z., Rahimi-Movaghar, V., Rahimzadeh, S., Rajati, F., Raju, S. B., Ramezankhani, A., Ranabhat, C. L., Rasella, D., Rashedi, V., Rawal, L., Reiner Jr, R. C., Renzaho, A. M. N., Rezaei, S., Rezapour, A., Riahi, S. M., Ribeiro, A. I., Roever, L., Roro, E. M., Roser, M., Roshandel, G., Roshani, D., Rostami, A., Rubagotti, E., Rubino, S., Sabour, S., Sadat, N., Sadeghi, E., Saeedi, R., Safari, Y., Safari-Faramani, R., Safdarian, M., Sahebkar, A., Salahshoor, M. R., Salam, N., Salamati, P., Salehi, F., Zahabi, S. S., Salimi, Y., Salimzadeh, H., Salomon, J. A., Sambala, E. Z., Samy, A. M., Santric Milicevic, M. M., Jose, B. P. S., Saraswathy, S. Y. I., Sarmiento-Suárez, R., Sartorius, B., Sathian, B., Saxena, S., Sbarra, A. N., Schaeffer, L. E., Schwebel, D. C., Sepanlou, S. G., Seyedmousavi, S., Shaahmadi, F., Shaikh, M. A., Shams-Beyranvand, M., Shamshirian, A., Shamsizadeh, M., Sharafi, K., Sharif, M., Sharif-Alhoseini, M., Sharifi, H., Sharma, J., Sharma, R., Sheikh, A., Shields, C., Shigematsu, M., Shiri, R., Shiue, I., Shuval, K., Siddiqi, T. J., Silva, J. P., Singh, J. A., Sinha, D. N., Sisay, M. M., Sisay, S., Sliwa, K., Smith, D. L., Somayaji, R., Soofi, M., Soriano, J. B., Sreeramareddy, C. T., Sudaryanto, A., Sufiyan, M. B., Sykes, B. L., Sylaja, P. N., Tabarés-Seisdedos, R., Tabb, K. M., Tabuchi, T., Taveira, N., Temsah, M. -H, Terkawi, A. S., Tessema, Z. T., Thankappan, K. R., Thirunavukkarasu, S., To, Q. G., Tovani-Palone, M. R., Tran, B. X., Tran, K. B., Ullah, I., Usman, M. S., Uthman, O. A., Vahedian-Azimi, A., Valdez, P. R., van Boven, J. F. M., Vasankari, T. J., Vasseghian, Y., Veisani, Y., Venketasubramanian, N., Violante, F. S., Vladimirov, S. K., Vlassov, V., Vos, T., Vu, G. T., Vujcic, I. S., Waheed, Y., Wakefield, J., Wang, H., Wang, Y., Wang, Y. -P, Ward, J. L., Weintraub, R. G., Weldegwergs, K. G., Weldesamuel, G. T., Westerman, R., Wiysonge, C. S., Wondafrash, D. Z., Woyczynski, L., Wu, A. -M, Xu, G., Yadegar, A., Yamada, T., Yazdi-Feyzabadi, V., Yilgwan, C. S., Yip, P., Yonemoto, N., Lebni, J. Y., Younis, M. Z., Yousefifard, M., Yousof, H. -AS. A., Yu, C., Yusefzadeh, H., Zabeh, E., Moghadam, T. Z., Bin Zaman, S., Zamani, M., Zandian, H., Zangeneh, A., Zerfu, T. A., Zhang, Y., Ziapour, A., Zodpey, S., Murray, C. J. L., and Hay, S. I.

Abstract

Since 2000, many countries have achieved considerable success in improving child survival, but localized progress remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2—to end preventable child deaths by 2030—we need consistently estimated data at the subnational level regarding child mortality rates and trends. Here we quantified, for the period 2000–2017, the subnational variation in mortality rates and number of deaths of neonates, infants and children under 5 years of age within 99 low- and middle-income countries using a geostatistical survival model. We estimated that 32% of children under 5 in these countries lived in districts that had attained rates of 25 or fewer child deaths per 1,000 live births by 2017, and that 58% of child deaths between 2000 and 2017 in these countries could have been averted in the absence of geographical inequality. This study enables the identification of high-mortality clusters, patterns of progress and geographical inequalities to inform appropriate investments and implementations that will help to improve the health of all populations. © 2019, The Author(s).

Published
2019
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3. Detection of magnetic circular dichroism using a transmission electron microscope

Author

Schattschneider, P., Rubino, S., Hébert, C., Rusz, J., Kunes, J., Novák, P., and Carlino, E.

Subjects
Circular dichroism -- Observations -- Methods, Electron microscopy -- Methods, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

EM with a twist The electron microscope, already a powerful research instrument, could become even more powerful following the discovery that magnetic circular dichroism can be detected with a conventional transmission electron microscope. Materials display magnetic circular dichroism if the absorption of left and right circularly polarized light differs in the presence of an applied magnetic field. Application of this effect using synchrotron X-ray photons is a powerful tool for the investigation of magnetic phenomena. The new technique -- EMCD or energy loss magnetic chiral dichroism -- exploits the similarities between X-ray absorption and inelastic electron scattering to give a TEM capabilities normally associated with expensive synchrotrons. EMCD could be useful in many fields including spintronics and nanomagnetism. Comparison of measurements of electron energy-loss magnetic chiral dichroism with X-ray magnetic circular dichroism spectra obtained from the same specimen, together with theoretical calculations, show that chiral atomic transitions in a specimen are accessible with inelastic electron scattering under particular scattering conditions. A material is said to exhibit dichroism if its photon absorption spectrum depends on the polarization of the incident radiation. In the case of X-ray magnetic circular dichroism (XMCD), the absorption cross-section of a ferromagnet or a paramagnet in a magnetic field changes when the helicity of a circularly polarized photon is reversed relative to the magnetization direction. Although similarities between X-ray absorption and electron energy-loss spectroscopy in a transmission electron microscope (TEM) have long been recognized, it has been assumed that extending such equivalence to circular dichroism would require the electron beam in the TEM to be spin-polarized. Recently, it was argued on theoretical grounds that this assumption is probably wrong.sup.1. Here we report the direct experimental detection of magnetic circular dichroism in a TEM. We compare our measurements of electron energy-loss magnetic chiral dichroism (EMCD) with XMCD spectra obtained from the same specimen that, together with theoretical calculations, show that chiral atomic transitions in a specimen are accessible with inelastic electron scattering under particular scattering conditions. This finding could have important consequences for the study of magnetism on the nanometre and subnanometre scales, as EMCD offers the potential for such spatial resolution down to the nanometre scale while providing depth information--in contrast to X-ray methods, which are mainly surface-sensitive., Author(s): P. Schattschneider [sup.1] , S. Rubino [sup.1] , C. Hébert [sup.1] , J. Rusz [sup.2] , J. Kunes [sup.2] , P. Novák [sup.2] , E. Carlino [sup.3] , M. [...]

Published
2006
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4. Ancient Plasmodium genomes shed light on the history of human malaria.

Author

Michel M, Skourtanioti E, Pierini F, Guevara EK, Mötsch A, Kocher A, Barquera R, Bianco RA, Carlhoff S, Coppola Bove L, Freilich S, Giffin K, Hermes T, Hiß A, Knolle F, Nelson EA, Neumann GU, Papac L, Penske S, Rohrlach AB, Salem N, Semerau L, Villalba-Mouco V, Abadie I, Aldenderfer M, Beckett JF, Brown M, Campus FGR, Chenghwa T, Cruz Berrocal M, Damašek L, Duffett Carlson KS, Durand R, Ernée M, Fântăneanu C, Frenzel H, García Atiénzar G, Guillén S, Hsieh E, Karwowski M, Kelvin D, Kelvin N, Khokhlov A, Kinaston RL, Korolev A, Krettek KL, Küßner M, Lai L, Look C, Majander K, Mandl K, Mazzarello V, McCormick M, de Miguel Ibáñez P, Murphy R, Németh RE, Nordqvist K, Novotny F, Obenaus M, Olmo-Enciso L, Onkamo P, Orschiedt J, Patrushev V, Peltola S, Romero A, Rubino S, Sajantila A, Salazar-García DC, Serrano E, Shaydullaev S, Sias E, Šlaus M, Stančo L, Swanston T, Teschler-Nicola M, Valentin F, Van de Vijver K, Varney TL, Vigil-Escalera Guirado A, Waters CK, Weiss-Krejci E, Winter E, Lamnidis TC, Prüfer K, Nägele K, Spyrou M, Schiffels S, Stockhammer PW, Haak W, Posth C, Warinner C, Bos KI, Herbig A, and Krause J

Subjects
Female, Humans, Male, Altitude, Americas epidemiology, Asia epidemiology, Biological Evolution, Disease Resistance genetics, Europe epidemiology, History, Ancient, Malaria, Falciparum epidemiology, Malaria, Falciparum history, Malaria, Falciparum parasitology, Malaria, Falciparum transmission, Malaria, Vivax epidemiology, Malaria, Vivax history, Malaria, Vivax parasitology, Malaria, Vivax transmission, Plasmodium falciparum genetics, Plasmodium falciparum isolation & purification, Plasmodium malariae genetics, Plasmodium malariae isolation & purification, Plasmodium vivax genetics, Plasmodium vivax isolation & purification, DNA, Ancient analysis, Genome, Mitochondrial genetics, Genome, Protozoan genetics, Malaria parasitology, Malaria history, Malaria transmission, Malaria epidemiology, Plasmodium genetics, Plasmodium classification
Abstract

Malaria-causing protozoa of the genus Plasmodium have exerted one of the strongest selective pressures on the human genome, and resistance alleles provide biomolecular footprints that outline the historical reach of these species 1 . Nevertheless, debate persists over when and how malaria parasites emerged as human pathogens and spread around the globe 1,2 . To address these questions, we generated high-coverage ancient mitochondrial and nuclear genome-wide data from P. falciparum, P. vivax and P. malariae from 16 countries spanning around 5,500 years of human history. We identified P. vivax and P. falciparum across geographically disparate regions of Eurasia from as early as the fourth and first millennia BCE, respectively; for P. vivax, this evidence pre-dates textual references by several millennia 3 . Genomic analysis supports distinct disease histories for P. falciparum and P. vivax in the Americas: similarities between now-eliminated European and peri-contact South American strains indicate that European colonizers were the source of American P. vivax, whereas the trans-Atlantic slave trade probably introduced P. falciparum into the Americas. Our data underscore the role of cross-cultural contacts in the dissemination of malaria, laying the biomolecular foundation for future palaeo-epidemiological research into the impact of Plasmodium parasites on human history. Finally, our unexpected discovery of P. falciparum in the high-altitude Himalayas provides a rare case study in which individual mobility can be inferred from infection status, adding to our knowledge of cross-cultural connectivity in the region nearly three millennia ago., (© 2024. The Author(s).)

Published
2024
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5. Metagenomics and microscope revealed T. trichiura and other intestinal parasites in a cesspit of an Italian nineteenth century aristocratic palace.

Author

Chessa D, Murgia M, Sias E, Deligios M, Mazzarello V, Fiamma M, Rovina D, Carenti G, Ganau G, Pintore E, Fiori M, Kay GL, Ponzeletti A, Cappuccinelli P, Kelvin DJ, Wain J, and Rubino S

Subjects
Animals, DNA, Protozoan genetics, DNA, Ribosomal genetics, Geologic Sediments parasitology, High-Throughput Nucleotide Sequencing, History, 19th Century, Host Specificity, Humans, Italy, Sequence Analysis, DNA, Trichuriasis history, Trichuris genetics, Trichuris isolation & purification, DNA, Ancient isolation & purification, Intestinal Diseases, Parasitic history, Metagenomics methods, RNA, Ribosomal, 18S genetics, Trichuris classification
Abstract

This study evidenced the presence of parasites in a cesspit of an aristocratic palace of nineteenth century in Sardinia (Italy) by the use of classical paleoparasitological techniques coupled with next-generation sequencing. Parasite eggs identified by microscopy included helminth genera pathogenic for humans and animals: the whipworm Trichuris sp., the roundworm Ascaris sp., the flatworm Dicrocoelium sp. and the fish tapeworm Diphyllobothrium sp. In addition, 18S rRNA metabarcoding and metagenomic sequencing analysis allowed the first description in Sardinia of aDNA of the human specific T. trichiura species and Ascaris genus. Their presence is important for understanding the health conditions, hygiene habits, agricultural practices and the diet of the local inhabitants in the period under study.

Published
2020
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6. Mapping 123 million neonatal, infant and child deaths between 2000 and 2017.

Author

Burstein R, Henry NJ, Collison ML, Marczak LB, Sligar A, Watson S, Marquez N, Abbasalizad-Farhangi M, Abbasi M, Abd-Allah F, Abdoli A, Abdollahi M, Abdollahpour I, Abdulkader RS, Abrigo MRM, Acharya D, Adebayo OM, Adekanmbi V, Adham D, Afshari M, Aghaali M, Ahmadi K, Ahmadi M, Ahmadpour E, Ahmed R, Akal CG, Akinyemi JO, Alahdab F, Alam N, Alamene GM, Alene KA, Alijanzadeh M, Alinia C, Alipour V, Aljunid SM, Almalki MJ, Al-Mekhlafi HM, Altirkawi K, Alvis-Guzman N, Amegah AK, Amini S, Amit AML, Anbari Z, Androudi S, Anjomshoa M, Ansari F, Antonio CAT, Arabloo J, Arefi Z, Aremu O, Armoon B, Arora A, Artaman A, Asadi A, Asadi-Aliabadi M, Ashraf-Ganjouei A, Assadi R, Ataeinia B, Atre SR, Quintanilla BPA, Ayanore MA, Azari S, Babaee E, Babazadeh A, Badawi A, Bagheri S, Bagherzadeh M, Baheiraei N, Balouchi A, Barac A, Bassat Q, Baune BT, Bayati M, Bedi N, Beghi E, Behzadifar M, Behzadifar M, Belay YB, Bell B, Bell ML, Berbada DA, Bernstein RS, Bhattacharjee NV, Bhattarai S, Bhutta ZA, Bijani A, Bohlouli S, Breitborde NJK, Britton G, Browne AJ, Nagaraja SB, Busse R, Butt ZA, Car J, Cárdenas R, Castañeda-Orjuela CA, Cerin E, Chanie WF, Chatterjee P, Chu DT, Cooper C, Costa VM, Dalal K, Dandona L, Dandona R, Daoud F, Daryani A, Das Gupta R, Davis I, Davis Weaver N, Davitoiu DV, De Neve JW, Demeke FM, Demoz GT, Deribe K, Desai R, Deshpande A, Desyibelew HD, Dey S, Dharmaratne SD, Dhimal M, Diaz D, Doshmangir L, Duraes AR, Dwyer-Lindgren L, Earl L, Ebrahimi R, Ebrahimpour S, Effiong A, Eftekhari A, Ehsani-Chimeh E, El Sayed I, El Sayed Zaki M, El Tantawi M, El-Khatib Z, Emamian MH, Enany S, Eskandarieh S, Eyawo O, Ezalarab M, Faramarzi M, Fareed M, Faridnia R, Faro A, Fazaeli AA, Fazlzadeh M, Fentahun N, Fereshtehnejad SM, Fernandes JC, Filip I, Fischer F, Foigt NA, Foroutan M, Francis JM, Fukumoto T, Fullman N, Gallus S, Gebre DG, Gebrehiwot TT, Gebremeskel GG, Gessner BD, Geta B, Gething PW, Ghadimi R, Ghadiri K, Ghajarzadeh M, Ghashghaee A, Gill PS, Gill TK, Golding N, Gomes NGM, Gona PN, Gopalani SV, Gorini G, Goulart BNG, Graetz N, Greaves F, Green MS, Guo Y, Haj-Mirzaian A, Haj-Mirzaian A, Hall BJ, Hamidi S, Haririan H, Haro JM, Hasankhani M, Hasanpoor E, Hasanzadeh A, Hassankhani H, Hassen HY, Hegazy MI, Hendrie D, Heydarpour F, Hird TR, Hoang CL, Hollerich G, Rad EH, Hoseini-Ghahfarokhi M, Hossain N, Hosseini M, Hosseinzadeh M, Hostiuc M, Hostiuc S, Househ M, Hsairi M, Ilesanmi OS, Imani-Nasab MH, Iqbal U, Irvani SSN, Islam N, Islam SMS, Jürisson M, Balalami NJ, Jalali A, Javidnia J, Jayatilleke AU, Jenabi E, Ji JS, Jobanputra YB, Johnson K, Jonas JB, Shushtari ZJ, Jozwiak JJ, Kabir A, Kahsay A, Kalani H, Kalhor R, Karami M, Karki S, Kasaeian A, Kassebaum NJ, Keiyoro PN, Kemp GR, Khabiri R, Khader YS, Khafaie MA, Khan EA, Khan J, Khan MS, Khang YH, Khatab K, Khater A, Khater MM, Khatony A, Khazaei M, Khazaei S, Khazaei-Pool M, Khubchandani J, Kianipour N, Kim YJ, Kimokoti RW, Kinyoki DK, Kisa A, Kisa S, Kolola T, Kosen S, Koul PA, Koyanagi A, Kraemer MUG, Krishan K, Krohn KJ, Kugbey N, Kumar GA, Kumar M, Kumar P, Kuupiel D, Lacey B, Lad SD, Lami FH, Larsson AO, Lee PH, Leili M, Levine AJ, Li S, Lim LL, Listl S, Longbottom J, Lopez JCF, Lorkowski S, Magdeldin S, Abd El Razek HM, Abd El Razek MM, Majeed A, Maleki A, Malekzadeh R, Malta DC, Mamun AA, Manafi N, Manda AL, Mansourian M, Martins-Melo FR, Masaka A, Massenburg BB, Maulik PK, Mayala BK, Mazidi M, McKee M, Mehrotra R, Mehta KM, Meles GG, Mendoza W, Menezes RG, Meretoja A, Meretoja TJ, Mestrovic T, Miller TR, Miller-Petrie MK, Mills EJ, Milne GJ, Mini GK, Mir SM, Mirjalali H, Mirrakhimov EM, Mohamadi E, Mohammad DK, Darwesh AM, Mezerji NMG, Mohammed AS, Mohammed S, Mokdad AH, Molokhia M, Monasta L, Moodley Y, Moosazadeh M, Moradi G, Moradi M, Moradi Y, Moradi-Lakeh M, Moradinazar M, Moraga P, Morawska L, Mosapour A, Mousavi SM, Mueller UO, Muluneh AG, Mustafa G, Nabavizadeh B, Naderi M, Nagarajan AJ, Nahvijou A, Najafi F, Nangia V, Ndwandwe DE, Neamati N, Negoi I, Negoi RI, Ngunjiri JW, Thi Nguyen HL, Nguyen LH, Nguyen SH, Nielsen KR, Ningrum DNA, Nirayo YL, Nixon MR, Nnaji CA, Nojomi M, Noroozi M, Nosratnejad S, Noubiap JJ, Motlagh SN, Ofori-Asenso R, Ogbo FA, Oladimeji KE, Olagunju AT, Olfatifar M, Olum S, Olusanya BO, Oluwasanu MM, Onwujekwe OE, Oren E, Ortega-Altamirano DDV, Ortiz A, Osarenotor O, Osei FB, Osgood-Zimmerman AE, Otstavnov SS, Owolabi MO, P A M, Pagheh AS, Pakhale S, Panda-Jonas S, Pandey A, Park EK, Parsian H, Pashaei T, Patel SK, Pepito VCF, Pereira A, Perkins S, Pickering BV, Pilgrim T, Pirestani M, Piroozi B, Pirsaheb M, Plana-Ripoll O, Pourjafar H, Puri P, Qorbani M, Quintana H, Rabiee M, Rabiee N, Radfar A, Rafiei A, Rahim F, Rahimi Z, Rahimi-Movaghar V, Rahimzadeh S, Rajati F, Raju SB, Ramezankhani A, Ranabhat CL, Rasella D, Rashedi V, Rawal L, Reiner RC Jr, Renzaho AMN, Rezaei S, Rezapour A, Riahi SM, Ribeiro AI, Roever L, Roro EM, Roser M, Roshandel G, Roshani D, Rostami A, Rubagotti E, Rubino S, Sabour S, Sadat N, Sadeghi E, Saeedi R, Safari Y, Safari-Faramani R, Safdarian M, Sahebkar A, Salahshoor MR, Salam N, Salamati P, Salehi F, Zahabi SS, Salimi Y, Salimzadeh H, Salomon JA, Sambala EZ, Samy AM, Santric Milicevic MM, Jose BPS, Saraswathy SYI, Sarmiento-Suárez R, Sartorius B, Sathian B, Saxena S, Sbarra AN, Schaeffer LE, Schwebel DC, Sepanlou SG, Seyedmousavi S, Shaahmadi F, Shaikh MA, Shams-Beyranvand M, Shamshirian A, Shamsizadeh M, Sharafi K, Sharif M, Sharif-Alhoseini M, Sharifi H, Sharma J, Sharma R, Sheikh A, Shields C, Shigematsu M, Shiri R, Shiue I, Shuval K, Siddiqi TJ, Silva JP, Singh JA, Sinha DN, Sisay MM, Sisay S, Sliwa K, Smith DL, Somayaji R, Soofi M, Soriano JB, Sreeramareddy CT, Sudaryanto A, Sufiyan MB, Sykes BL, Sylaja PN, Tabarés-Seisdedos R, Tabb KM, Tabuchi T, Taveira N, Temsah MH, Terkawi AS, Tessema ZT, Thankappan KR, Thirunavukkarasu S, To QG, Tovani-Palone MR, Tran BX, Tran KB, Ullah I, Usman MS, Uthman OA, Vahedian-Azimi A, Valdez PR, van Boven JFM, Vasankari TJ, Vasseghian Y, Veisani Y, Venketasubramanian N, Violante FS, Vladimirov SK, Vlassov V, Vos T, Vu GT, Vujcic IS, Waheed Y, Wakefield J, Wang H, Wang Y, Wang YP, Ward JL, Weintraub RG, Weldegwergs KG, Weldesamuel GT, Westerman R, Wiysonge CS, Wondafrash DZ, Woyczynski L, Wu AM, Xu G, Yadegar A, Yamada T, Yazdi-Feyzabadi V, Yilgwan CS, Yip P, Yonemoto N, Lebni JY, Younis MZ, Yousefifard M, Yousof HSA, Yu C, Yusefzadeh H, Zabeh E, Moghadam TZ, Bin Zaman S, Zamani M, Zandian H, Zangeneh A, Zerfu TA, Zhang Y, Ziapour A, Zodpey S, Murray CJL, and Hay SI

Subjects
Child, Geography, Global Health, Humans, Infant, Infant, Newborn, Organizational Objectives, Public Health, Socioeconomic Factors, United Nations, Child Mortality trends, Infant Mortality trends
Abstract

Since 2000, many countries have achieved considerable success in improving child survival, but localized progress remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2-to end preventable child deaths by 2030-we need consistently estimated data at the subnational level regarding child mortality rates and trends. Here we quantified, for the period 2000-2017, the subnational variation in mortality rates and number of deaths of neonates, infants and children under 5 years of age within 99 low- and middle-income countries using a geostatistical survival model. We estimated that 32% of children under 5 in these countries lived in districts that had attained rates of 25 or fewer child deaths per 1,000 live births by 2017, and that 58% of child deaths between 2000 and 2017 in these countries could have been averted in the absence of geographical inequality. This study enables the identification of high-mortality clusters, patterns of progress and geographical inequalities to inform appropriate investments and implementations that will help to improve the health of all populations.

Published
2019
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8. Quantitative analysis of magnetic spin and orbital moments from an oxidized iron (1 1 0) surface using electron magnetic circular dichroism.

Author

Thersleff T, Rusz J, Rubino S, Hjörvarsson B, Ito Y, J Zaluzec N, and Leifer K

Abstract

Understanding the ramifications of reduced crystalline symmetry on magnetic behavior is a critical step in improving our understanding of nanoscale and interfacial magnetism. However, investigations of such effects are often controversial largely due to the challenges inherent in directly correlating nanoscale stoichiometry and structure to magnetic behavior. Here, we describe how to use Transmission Electron Microscope (TEM) to obtain Electron Magnetic Circular Dichroism (EMCD) signals as a function of scattering angle to locally probe the magnetic behavior of thin oxide layers grown on an Fe (1 1 0) surface. Experiments and simulations both reveal a strong dependence of the magnetic orbital to spin ratio on its scattering vector in reciprocal space. We exploit this variation to extract the magnetic properties of the oxide cladding layer, showing that it locally may exhibit an enhanced orbital to spin moment ratio. This finding is supported here by both spatially and angularly resolved EMCD measurements, opening up the way for compelling investigations into how magnetic properties are affected by nanoscale features.

Published
2015
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9. Immunity toward H1N1 influenza hemagglutinin of historical and contemporary strains suggests protection and vaccine failure.

Author

Huang SS, Lin Z, Banner D, León AJ, Paquette SG, Rubin B, Rubino S, Guan Y, Kelvin DJ, and Kelvin AA

Subjects
Animals, Influenza A Virus, H1N1 Subtype drug effects, Species Specificity, Ferrets virology, Hemagglutinin Glycoproteins, Influenza Virus immunology, Immunity, Innate immunology, Influenza A Virus, H1N1 Subtype classification, Influenza A Virus, H1N1 Subtype immunology, Viral Vaccines administration & dosage
Abstract

Evolution of H1N1 influenza A outbreaks of the past 100 years is interesting and significantly complex and details of H1N1 genetic drift remains unknown. Here we investigated the clinical characteristics and immune cross-reactivity of significant historical H1N1 strains. We infected ferrets with H1N1 strains from 1943, 1947, 1977, 1986, 1999, and 2009 and showed each produced a unique clinical signature. We found significant cross-reactivity between viruses with similar HA sequences. Interestingly, A/FortMonmouth/1/1947 antisera cross-reacted with A/USSR/90/1977 virus, thought to be a 1947 resurfaced virus. Importantly, our immunological data that didn't show cross-reactivity can be extrapolated to failure of past H1N1 influenza vaccines, ie. 1947, 1986 and 2009. Together, our results help to elucidate H1N1 immuno-genetic alterations that occurred in the past 100 years and immune responses caused by H1N1 evolution. This work will facilitate development of future influenza therapeutics and prophylactics such as influenza vaccines.

Published
2013
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10. Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut.

Author

Fritz JH, Rojas OL, Simard N, McCarthy DD, Hapfelmeier S, Rubino S, Robertson SJ, Larijani M, Gosselin J, Ivanov II, Martin A, Casellas R, Philpott DJ, Girardin SE, McCoy KD, Macpherson AJ, Paige CJ, and Gommerman JL

Subjects
Animals, Bone Marrow Cells cytology, Cell Lineage, Cells, Cultured, Chimera immunology, Citrobacter rodentium immunology, Coculture Techniques, Female, Germ-Free Life, Granulocytes cytology, Granulocytes metabolism, Immunity, Innate immunology, Immunoglobulin A biosynthesis, Intestinal Mucosa cytology, Intestinal Mucosa immunology, Intestine, Small microbiology, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Monocytes cytology, Monocytes metabolism, Nitric Oxide Synthase Type II biosynthesis, Nitric Oxide Synthase Type II deficiency, Nitric Oxide Synthase Type II metabolism, Phenotype, Plasma Cells metabolism, Spleen cytology, Stromal Cells cytology, Tumor Necrosis Factor-alpha biosynthesis, Tumor Necrosis Factor-alpha deficiency, Tumor Necrosis Factor-alpha immunology, Tumor Necrosis Factor-alpha metabolism, Immunoglobulin A immunology, Intestine, Small cytology, Intestine, Small immunology, Plasma Cells cytology, Plasma Cells immunology
Abstract

The largest mucosal surface in the body is in the gastrointestinal tract, a location that is heavily colonized by microbes that are normally harmless. A key mechanism required for maintaining a homeostatic balance between this microbial burden and the lymphocytes that densely populate the gastrointestinal tract is the production and transepithelial transport of poly-reactive IgA (ref. 1). Within the mucosal tissues, B cells respond to cytokines, sometimes in the absence of T-cell help, undergo class switch recombination of their immunoglobulin receptor to IgA, and differentiate to become plasma cells. However, IgA-secreting plasma cells probably have additional attributes that are needed for coping with the tremendous bacterial load in the gastrointestinal tract. Here we report that mouse IgA(+) plasma cells also produce the antimicrobial mediators tumour-necrosis factor-α (TNF-α) and inducible nitric oxide synthase (iNOS), and express many molecules that are commonly associated with monocyte/granulocytic cell types. The development of iNOS-producing IgA(+) plasma cells can be recapitulated in vitro in the presence of gut stroma, and the acquisition of this multifunctional phenotype in vivo and in vitro relies on microbial co-stimulation. Deletion of TNF-α and iNOS in B-lineage cells resulted in a reduction in IgA production, altered diversification of the gut microbiota and poor clearance of a gut-tropic pathogen. These findings reveal a novel adaptation to maintaining homeostasis in the gut, and extend the repertoire of protective responses exhibited by some B-lineage cells.

Published
2011
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