1. Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in pediatric patients: A new classification from the European society for blood and marrow transplantation
- Author
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Akif Yeşilipek, J.-H. Dalle, Fiona L Dignan, Isaac Yaniv, Enric Carreras, Francesco Locatelli, Rob Wynn, Selim Corbacioglu, M. Mohty, E. Trigoso, C Peters, A. Schulz, Peter Bader, Adriana Balduzzi, Simone Cesaro, Petr Sedlacek, Jacek Toporski, Paul G. Richardson, A.C. Lankester, B. Gruhn, A Pagliuca, K. Vetteranta, Elisabeth Wallhult, Brenda Gibson, Jacek Wachowiak, Marc Ansari, Jerry Stein, Tayfun Guengoer, K W Sykora, Corbacioglu, S, Carreras, E, Ansari, M, Balduzzi, A, Cesaro, S, Dalle, J, Dignan, F, Gibson, B, Guengoer, T, Gruhn, B, Lankester, A, Locatelli, F, Pagliuca, A, Peters, C, Richardson, P, Schulz, A, Sedlacek, P, Stein, J, Sykora, K, Toporski, J, Trigoso, E, Vetteranta, K, Wachowiak, J, Wallhult, E, Wynn, R, Yaniv, I, Yesilipek, A, Mohty, M, Bader, P, Clinicum, Lastentautien yksikkö, Children's Hospital, University of Helsinki, and HUS Children and Adolescents
- Subjects
Male ,Transplantation, venous occlusive disease, hematopoietic stem cell transplantation, childhood, complications, defibrotide ,Hepatic Veno-Occlusive Disease ,High dose chemotherapy ,HIGH-DOSE CHEMOTHERAPY ,0302 clinical medicine ,veno-occlusive disease, stem cell transplantation, prophylaxis, guidelines ,Risk Factors ,3123 Gynaecology and paediatrics ,hepatic venoocclusive disease ,HIGH-RISK NEUROBLASTOMA ,Medicine ,High risk neuroblastoma ,guidelines ,stem-cell transplantation ,DOPPLER-ULTRASONOGRAPHY ,ddc:618 ,Incidence ,VOD ,Hematology ,3. Good health ,Europe ,Treatment Outcome ,Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA ,030220 oncology & carcinogenesis ,Severity Criteria ,Female ,GEMTUZUMAB OZOGAMICIN EXPOSURE ,Veno-Occlusive Disease ,MYELOABLATIVE CHEMOTHERAPY ,Radiology ,prophylaxis ,Myeloablative chemotherapy ,medicine.medical_specialty ,stem cell transplantation ,INTRAVENOUS BUSULFAN ,03 medical and health sciences ,VENOCCLUSIVE DISEASE ,Humans ,veno-occlusive disease ,Special Report ,Transplantation ,Intravenous busulfan ,business.industry ,hematopoietic cell transplantation ,SOS/VOD ,children ,acute lymphoblastic-leukemia ,bacteria ,business ,030215 immunology - Abstract
The advances in hematopoietic cell transplantation (HCT) over the last decade have led to a transplant-related mortality below 15%. Hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a life-threatening complication of HCT that belongs to a group of diseases increasingly identified as transplant-related, systemic endothelial diseases. In most cases, SOS/VOD resolves within weeks; however, severe SOS/VOD results in multi-organ dysfunction/failure with a mortality rate > 80%. A timely diagnosis of SOS/VOD is of critical importance, given the availability of therapeutic options with favorable tolerability. Current diagnostic criteria are used for adults and children. However, over the last decade it has become clear that SOS/VOD is significantly different between the age groups in terms of incidence, genetic predisposition, clinical presentation, prevention, treatment and outcome. Improved understanding of SOS/VOD and the availability of effective treatment questions the use of the Baltimore and Seattle criteria for diagnosing SOS/VOD in children. The aim of this position paper is to propose new diagnostic and severity criteria for SOS/VOD in children on behalf of the European Society for Blood and Marrow Transplantation.
- Published
- 2018