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16,811 results on '"Neuroscience"'

1. Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target

Author

TN groep Pasterkamp, Translational Neuroscience, Brain, Regenerative Medicine and Stem Cells, Caldi Gomes, Lucas, Hänzelmann, Sonja, Hausmann, Fabian, Khatri, Robin, Oller, Sergio, Parvaz, Mojan, Tzeplaeff, Laura, Pasetto, Laura, Gebelin, Marie, Ebbing, Melanie, Holzapfel, Constantin, Columbro, Stefano Fabrizio, Scozzari, Serena, Knöferle, Johanna, Cordts, Isabell, Demleitner, Antonia F., Deschauer, Marcus, Dufke, Claudia, Sturm, Marc, Zhou, Qihui, Zelina, Pavol, Sudria-Lopez, Emma, Haack, Tobias B., Streb, Sebastian, Kuzma-Kozakiewicz, Magdalena, Edbauer, Dieter, Pasterkamp, R. Jeroen, Laczko, Endre, Rehrauer, Hubert, Schlapbach, Ralph, Carapito, Christine, Bonetto, Valentina, Bonn, Stefan, Lingor, Paul, TN groep Pasterkamp, Translational Neuroscience, Brain, Regenerative Medicine and Stem Cells, Caldi Gomes, Lucas, Hänzelmann, Sonja, Hausmann, Fabian, Khatri, Robin, Oller, Sergio, Parvaz, Mojan, Tzeplaeff, Laura, Pasetto, Laura, Gebelin, Marie, Ebbing, Melanie, Holzapfel, Constantin, Columbro, Stefano Fabrizio, Scozzari, Serena, Knöferle, Johanna, Cordts, Isabell, Demleitner, Antonia F., Deschauer, Marcus, Dufke, Claudia, Sturm, Marc, Zhou, Qihui, Zelina, Pavol, Sudria-Lopez, Emma, Haack, Tobias B., Streb, Sebastian, Kuzma-Kozakiewicz, Magdalena, Edbauer, Dieter, Pasterkamp, R. Jeroen, Laczko, Endre, Rehrauer, Hubert, Schlapbach, Ralph, Carapito, Christine, Bonetto, Valentina, Bonn, Stefan, and Lingor, Paul

Published
2024

2. Alternative platelet differentiation pathways initiated by nonhierarchically related hematopoietic stem cells

Author

Brain, Translational Neuroscience, Carrelha, Joana, Mazzi, Stefania, Winroth, Axel, Hagemann-Jensen, Michael, Ziegenhain, Christoph, Högstrand, Kari, Seki, Masafumi, Brennan, Margs S., Lehander, Madeleine, Wu, Bishan, Meng, Yiran, Markljung, Ellen, Norfo, Ruggiero, Ishida, Hisashi, Belander Strålin, Karin, Grasso, Francesca, Simoglou Karali, Christina, Aliouat, Affaf, Hillen, Amy, Chari, Edwin, Siletti, Kimberly, Thongjuea, Supat, Mead, Adam J., Linnarsson, Sten, Nerlov, Claus, Sandberg, Rickard, Yoshizato, Tetsuichi, Woll, Petter S., Jacobsen, Sten Eirik W., Brain, Translational Neuroscience, Carrelha, Joana, Mazzi, Stefania, Winroth, Axel, Hagemann-Jensen, Michael, Ziegenhain, Christoph, Högstrand, Kari, Seki, Masafumi, Brennan, Margs S., Lehander, Madeleine, Wu, Bishan, Meng, Yiran, Markljung, Ellen, Norfo, Ruggiero, Ishida, Hisashi, Belander Strålin, Karin, Grasso, Francesca, Simoglou Karali, Christina, Aliouat, Affaf, Hillen, Amy, Chari, Edwin, Siletti, Kimberly, Thongjuea, Supat, Mead, Adam J., Linnarsson, Sten, Nerlov, Claus, Sandberg, Rickard, Yoshizato, Tetsuichi, Woll, Petter S., and Jacobsen, Sten Eirik W.

Published
2024

3. Circular RNAs regulate neuron size and migration of midbrain dopamine neurons during development

Author

TN groep Pasterkamp, Brain, TN groep Hol, Onderzoek NCH, Translational Neuroscience, Regenerative Medicine and Stem Cells, Rybiczka-Tešulov, Mateja, Garritsen, Oxana, Venø, Morten T., Wieg, Laura, Dijk, Roland van, Rahimi, Karim, Gomes-Duarte, Andreia, Wit, Marina de, van de Haar, Lieke L., Michels, Lars, van Kronenburg, Nicky C.H., van der Meer, Christiaan, Kjems, Jørgen, Vangoor, Vamshidhar R., Pasterkamp, R. Jeroen, TN groep Pasterkamp, Brain, TN groep Hol, Onderzoek NCH, Translational Neuroscience, Regenerative Medicine and Stem Cells, Rybiczka-Tešulov, Mateja, Garritsen, Oxana, Venø, Morten T., Wieg, Laura, Dijk, Roland van, Rahimi, Karim, Gomes-Duarte, Andreia, Wit, Marina de, van de Haar, Lieke L., Michels, Lars, van Kronenburg, Nicky C.H., van der Meer, Christiaan, Kjems, Jørgen, Vangoor, Vamshidhar R., and Pasterkamp, R. Jeroen

Published
2024

5. ATAXIN-2 intermediate-length polyglutamine expansions elicit ALS-associated metabolic and immune phenotypes

Author

Brain, TN groep Pasterkamp, Opleiding Neurologie, Projectafdeling ALS, TN groep Joëls, Cancer, Regenerative Medicine and Stem Cells, Infection & Immunity, CMM Groep Coffer, Translational Neuroscience, Neurogenetica, In Vivo NMR ISI, Neurologen, Neuromuscular Disorders, Genetic Risks, Vieira de Sá, Renata, Sudria-Lopez, Emma, Cañizares Luna, Marta, Harschnitz, Oliver, van den Heuvel, Dianne M A, Kling, Sandra, Vonk, Danielle, Westeneng, Henk-Jan, Karst, Henk, Bloemenkamp, Lauri, Varderidou-Minasian, Suzy, Schlegel, Domino K, Mars, Mayte, Broekhoven, Mark H, van Kronenburg, Nicky C H, Adolfs, Youri, Vangoor, Vamshidhar R, de Jongh, Rianne, Ljubikj, Tijana, Peeters, Lianne, Seeler, Sabine, Mocholi, Enric, Basak, Onur, Gordon, David, Giuliani, Fabrizio, Verhoeff, Tessa, Korsten, Giel, Calafat Pla, Teresa, Venø, Morten T, Kjems, Jørgen, Talbot, Kevin, van Es, Michael A, Veldink, Jan H, van den Berg, Leonard H, Zelina, Pavol, Pasterkamp, R Jeroen, Brain, TN groep Pasterkamp, Opleiding Neurologie, Projectafdeling ALS, TN groep Joëls, Cancer, Regenerative Medicine and Stem Cells, Infection & Immunity, CMM Groep Coffer, Translational Neuroscience, Neurogenetica, In Vivo NMR ISI, Neurologen, Neuromuscular Disorders, Genetic Risks, Vieira de Sá, Renata, Sudria-Lopez, Emma, Cañizares Luna, Marta, Harschnitz, Oliver, van den Heuvel, Dianne M A, Kling, Sandra, Vonk, Danielle, Westeneng, Henk-Jan, Karst, Henk, Bloemenkamp, Lauri, Varderidou-Minasian, Suzy, Schlegel, Domino K, Mars, Mayte, Broekhoven, Mark H, van Kronenburg, Nicky C H, Adolfs, Youri, Vangoor, Vamshidhar R, de Jongh, Rianne, Ljubikj, Tijana, Peeters, Lianne, Seeler, Sabine, Mocholi, Enric, Basak, Onur, Gordon, David, Giuliani, Fabrizio, Verhoeff, Tessa, Korsten, Giel, Calafat Pla, Teresa, Venø, Morten T, Kjems, Jørgen, Talbot, Kevin, van Es, Michael A, Veldink, Jan H, van den Berg, Leonard H, Zelina, Pavol, and Pasterkamp, R Jeroen

Published
2024

6. Publisher Correction: Purkinje cell microzones mediate distinct kinematics of a single movement (Nature Communications, (2023), 14, 1, (4358), 10.1038/s41467-023-40111-5)

Author

TN groep Pasterkamp, Brain, Translational Neuroscience, Regenerative Medicine and Stem Cells, Blot, François G.C., White, Joshua J., van Hattem, Amy, Scotti, Licia, Balaji, Vaishnavi, Adolfs, Youri, Pasterkamp, R. Jeroen, De Zeeuw, Chris I., Schonewille, Martijn, TN groep Pasterkamp, Brain, Translational Neuroscience, Regenerative Medicine and Stem Cells, Blot, François G.C., White, Joshua J., van Hattem, Amy, Scotti, Licia, Balaji, Vaishnavi, Adolfs, Youri, Pasterkamp, R. Jeroen, De Zeeuw, Chris I., and Schonewille, Martijn

Published
2023

7. SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability

Author

TN groep Pasterkamp, Brain, Translational Neuroscience, Regenerative Medicine and Stem Cells, Lettieri, Antonella, Oleari, Roberto, van den Munkhof, Marleen Hester, van Battum, Eljo Yvette, Verhagen, Marieke Geerte, Tacconi, Carlotta, Spreafico, Marco, Paganoni, Alyssa Julia Jennifer, Azzarelli, Roberta, Andre’, Valentina, Amoruso, Federica, Palazzolo, Luca, Eberini, Ivano, Dunkel, Leo, Howard, Sasha Rose, Fantin, Alessandro, Pasterkamp, Ronald Jeroen, Cariboni, Anna, TN groep Pasterkamp, Brain, Translational Neuroscience, Regenerative Medicine and Stem Cells, Lettieri, Antonella, Oleari, Roberto, van den Munkhof, Marleen Hester, van Battum, Eljo Yvette, Verhagen, Marieke Geerte, Tacconi, Carlotta, Spreafico, Marco, Paganoni, Alyssa Julia Jennifer, Azzarelli, Roberta, Andre’, Valentina, Amoruso, Federica, Palazzolo, Luca, Eberini, Ivano, Dunkel, Leo, Howard, Sasha Rose, Fantin, Alessandro, Pasterkamp, Ronald Jeroen, and Cariboni, Anna

Published
2023

8. Purkinje cell microzones mediate distinct kinematics of a single movement

Author

TN groep Pasterkamp, Brain, Translational Neuroscience, Regenerative Medicine and Stem Cells, Blot, François G.C., White, Joshua J., van Hattem, Amy, Scotti, Licia, Balaji, Vaishnavi, Adolfs, Youri, Pasterkamp, R. Jeroen, De Zeeuw, Chris I., Schonewille, Martijn, TN groep Pasterkamp, Brain, Translational Neuroscience, Regenerative Medicine and Stem Cells, Blot, François G.C., White, Joshua J., van Hattem, Amy, Scotti, Licia, Balaji, Vaishnavi, Adolfs, Youri, Pasterkamp, R. Jeroen, De Zeeuw, Chris I., and Schonewille, Martijn

Published
2023

9. Development, wiring and function of dopamine neuron subtypes

Author

TN groep Pasterkamp, Brain, Translational Neuroscience, Regenerative Medicine and Stem Cells, Garritsen, Oxana, van Battum, Eljo Y., Grossouw, Laurens M., Pasterkamp, R. Jeroen, TN groep Pasterkamp, Brain, Translational Neuroscience, Regenerative Medicine and Stem Cells, Garritsen, Oxana, van Battum, Eljo Y., Grossouw, Laurens M., and Pasterkamp, R. Jeroen

Published
2023

10. In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging

Author

In Vivo NMR ISI, Circulatory Health, Brain, Translational Neuroscience, Cancer, Stroke, Meerwaldt, Anu E., Straathof, Milou, Oosterveld, Wija, van Heijningen, Caroline L., van Leent, Mandy M.T., Toner, Yohana C., Munitz, Jazz, Teunissen, Abraham J.P., Daemen, Charlotte C., van der Toorn, Annette, van Vliet, Gerard, van Tilborg, Geralda A.F., De Feyter, Henk M., de Graaf, Robin A., Hol, Elly M., Mulder, Willem J.M., Dijkhuizen, Rick M., In Vivo NMR ISI, Circulatory Health, Brain, Translational Neuroscience, Cancer, Stroke, Meerwaldt, Anu E., Straathof, Milou, Oosterveld, Wija, van Heijningen, Caroline L., van Leent, Mandy M.T., Toner, Yohana C., Munitz, Jazz, Teunissen, Abraham J.P., Daemen, Charlotte C., van der Toorn, Annette, van Vliet, Gerard, van Tilborg, Geralda A.F., De Feyter, Henk M., de Graaf, Robin A., Hol, Elly M., Mulder, Willem J.M., and Dijkhuizen, Rick M.

Published
2023

12. From anticipation to impulsivity in Parkinson's disease

Author

UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, Missal, Marcus, UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, and Missal, Marcus

Abstract

Anticipatory actions require to keep track of elapsed time and inhibitory control. These cognitive functions could be impacted in Parkinson's disease (iPD). To test this hypothesis, a saccadic reaction time task was used where a visual warning stimulus (WS) predicted the occurrence of an imperative one (IS) appearing after a short delay. In the implicit condition, subjects were not informed about the duration of the delay, disfavoring anticipatory behavior but leaving inhibitory control unaltered. In the explicit condition, delay duration was cued. This should favor anticipatory behavior and perhaps alter inhibitory control. This hypothesis was tested in controls (N = 18) and age-matched iPD patients (N = 20; ON and OFF L-DOPA). We found that the latency distribution of saccades before the IS was bimodal. The 1st mode weakly depended on temporal information and was more prominent in iPD. Saccades in this mode were premature and could result of a lack of inhibition. The 2nd mode covaried with cued duration suggesting that these movements were genuine anticipatory saccades. The explicit condition increased the probability of anticipatory saccades before the IS in controls and iPDON but not iPDOFF patients. Furthermore, in iPD patients the probability of sequences of 1st mode premature responses increased. In conclusion, the triggering of a premature saccade or the initiation of a controlled anticipatory one could be conceptualized as the output of two independent stochastic processes. Altered time perception and increased motor impulsivity could alter the balance between these two processes in favor of the latter in iPD, particularly OFF L-Dopa.

Published
2022

14. Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer's disease

Author

TN groep Hol, Brain, Translational Neuroscience, Cancer, Fernández Zapata, Camila, Giacomello, Ginevra, Spruth, Eike J, Middeldorp, Jinte, Gallaccio, Gerardina, Dehlinger, Adeline, Dames, Claudia, Leman, Julia K H, van Dijk, Roland E, Meisel, Andreas, Schlickeiser, Stephan, Kunkel, Desiree, Hol, Elly M, Paul, Friedemann, Parr, Maria Kristina, Priller, Josef, Böttcher, Chotima, TN groep Hol, Brain, Translational Neuroscience, Cancer, Fernández Zapata, Camila, Giacomello, Ginevra, Spruth, Eike J, Middeldorp, Jinte, Gallaccio, Gerardina, Dehlinger, Adeline, Dames, Claudia, Leman, Julia K H, van Dijk, Roland E, Meisel, Andreas, Schlickeiser, Stephan, Kunkel, Desiree, Hol, Elly M, Paul, Friedemann, Parr, Maria Kristina, Priller, Josef, and Böttcher, Chotima

Published
2022

15. Best practice standards for circular RNA research

Author

Translational Neuroscience, Brain, Regenerative Medicine and Stem Cells, Nielsen, Anne F., Bindereif, Albrecht, Bozzoni, Irene, Hanan, Mor, Hansen, Thomas B., Irimia, Manuel, Kadener, Sebastian, Kristensen, Lasse S., Legnini, Ivano, Morlando, Mariangela, Jarlstad Olesen, Morten T., Pasterkamp, R. Jeroen, Preibisch, Stephan, Rajewsky, Nikolaus, Suenkel, Christin, Kjems, Jørgen, Translational Neuroscience, Brain, Regenerative Medicine and Stem Cells, Nielsen, Anne F., Bindereif, Albrecht, Bozzoni, Irene, Hanan, Mor, Hansen, Thomas B., Irimia, Manuel, Kadener, Sebastian, Kristensen, Lasse S., Legnini, Ivano, Morlando, Mariangela, Jarlstad Olesen, Morten T., Pasterkamp, R. Jeroen, Preibisch, Stephan, Rajewsky, Nikolaus, Suenkel, Christin, and Kjems, Jørgen

Published
2022

17. Microglial transcriptomics meets genetics: new disease leads (Feb, 10.1038/s41582-022-00633-w, 2022): Microglial transcriptomics meets genetics: new disease leads (Nature Reviews Neurology, (2022), 18, 4, (191-192), 10.1038/s41582-022-00633-w)

Author

Translational Neuroscience, Brain, Cancer, Regenerative Medicine and Stem Cells, Hol, Elly M., Pasterkamp, R. Jeroen, Translational Neuroscience, Brain, Cancer, Regenerative Medicine and Stem Cells, Hol, Elly M., and Pasterkamp, R. Jeroen

Published
2022

18. Single-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors

Author

TN groep Hol, TN groep Pasterkamp, Translational Neuroscience, Cancer, Brain, Regenerative Medicine and Stem Cells, Donega, Vanessa, van der Geest, Astrid T., Sluijs, Jacqueline A., van Dijk, Roland E., Wang, Chi Chiu, Basak, Onur, Pasterkamp, R. Jeroen, Hol, Elly M., TN groep Hol, TN groep Pasterkamp, Translational Neuroscience, Cancer, Brain, Regenerative Medicine and Stem Cells, Donega, Vanessa, van der Geest, Astrid T., Sluijs, Jacqueline A., van Dijk, Roland E., Wang, Chi Chiu, Basak, Onur, Pasterkamp, R. Jeroen, and Hol, Elly M.

Published
2022

19. Microglial transcriptomics meets genetics: new disease leads

Author

Translational Neuroscience, Brain, Cancer, Regenerative Medicine and Stem Cells, Hol, Elly M, Pasterkamp, R Jeroen, Translational Neuroscience, Brain, Cancer, Regenerative Medicine and Stem Cells, Hol, Elly M, and Pasterkamp, R Jeroen

Published
2022

20. Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology (Nature Genetics, (2021), 53, 12, (1636-1648), 10.1038/s41588-021-00973-1)

Author

Neurologen, AIOS Psychiatrie, Neurogenetica, Genetica Klinische Genetica, Opleiding Neurologie, Brain, Hersenen-Bedrijfsvoering, Translational Neuroscience, Regenerative Medicine and Stem Cells, Projectafdeling ALS, Genetic Risks, Neuromuscular Disorders, SLALOM Consortium, Neurologen, AIOS Psychiatrie, Neurogenetica, Genetica Klinische Genetica, Opleiding Neurologie, Brain, Hersenen-Bedrijfsvoering, Translational Neuroscience, Regenerative Medicine and Stem Cells, Projectafdeling ALS, Genetic Risks, Neuromuscular Disorders, and SLALOM Consortium

Published
2022

21. Analysis of the circRNA and T-UCR populations identifies convergent pathways in mouse and human models of Rett syndrome

Author

TN groep Pasterkamp, Translational Neuroscience, Brain, Regenerative Medicine and Stem Cells, Siqueira, Edilene, Obiols-Guardia, Aida, Jorge-Torres, Olga C., Oliveira-Mateos, Cristina, Soler, Marta, Ramesh-Kumar, Deepthi, Setién, Fernando, van Rossum, Daniëlle, Pascual-Alonso, Ainhoa, Xiol, Clara, Ivan, Cristina, Shimizu, Masayoshi, Armstrong, Judith, Calin, George A., Pasterkamp, R. Jeroen, Esteller, Manel, Guil, Sonia, TN groep Pasterkamp, Translational Neuroscience, Brain, Regenerative Medicine and Stem Cells, Siqueira, Edilene, Obiols-Guardia, Aida, Jorge-Torres, Olga C., Oliveira-Mateos, Cristina, Soler, Marta, Ramesh-Kumar, Deepthi, Setién, Fernando, van Rossum, Daniëlle, Pascual-Alonso, Ainhoa, Xiol, Clara, Ivan, Cristina, Shimizu, Masayoshi, Armstrong, Judith, Calin, George A., Pasterkamp, R. Jeroen, Esteller, Manel, and Guil, Sonia

Published
2022

22. GFAP splice variants fine-tune glioma cell invasion and tumour dynamics by modulating migration persistence

Author

TN groep Hol, Brain, Neurochirurgie, Cancer, Hubrecht Institute with UMC, Translational Neuroscience, Uceda-Castro, Rebeca, van Asperen, Jessy V., Vennin, Claire, Sluijs, Jacqueline A., van Bodegraven, Emma J., Margarido, Andreia S., Robe, Pierre A.J., van Rheenen, Jacco, Hol, Elly M., TN groep Hol, Brain, Neurochirurgie, Cancer, Hubrecht Institute with UMC, Translational Neuroscience, Uceda-Castro, Rebeca, van Asperen, Jessy V., Vennin, Claire, Sluijs, Jacqueline A., van Bodegraven, Emma J., Margarido, Andreia S., Robe, Pierre A.J., van Rheenen, Jacco, and Hol, Elly M.

Published
2022

23. Insular responses to transient painful and non‑painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG

Author

UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de neurochirurgie, UCL - (SLuc) Service de neurologie, Liberati, Giulia, Mulders, Dounia, Algoet, Maxime, van den Broeke, Emanuel, Ferrao Santos, Susana, Ribeiro Vaz, José Géraldo, Raftopoulos, Christian, Mouraux, André, UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de neurochirurgie, UCL - (SLuc) Service de neurologie, Liberati, Giulia, Mulders, Dounia, Algoet, Maxime, van den Broeke, Emanuel, Ferrao Santos, Susana, Ribeiro Vaz, José Géraldo, Raftopoulos, Christian, and Mouraux, André

Abstract

Brief thermo-nociceptive stimuli elicit low-frequency phase-locked local field potentials (LFPs) and high-frequency gamma-band oscillations (GBOs) in the human insula. Although neither of these responses constitute a direct correlate of pain perception, previous findings suggest that insular GBOs may be strongly related to the activation of the spinothalamic system and/or to the processing of thermal information. To disentangle these different features of the stimulation, we compared the insular responses to brief painful thermonociceptive stimuli, non-painful cool stimuli, mechano-nociceptive stimuli, and innocuous vibrotactile stimuli, recorded using intracerebral electroencephalograpic activity in 7 epileptic patients (9 depth electrodes, 58 insular contacts). All four types of stimuli elicited consistent low-frequency phase-locked LFPs throughout the insula, possibly reflecting supramodal activity. The latencies of thermo-nociceptive and cool low-frequency phase-locked LFPs were shorter in the posterior insula compared to the anterior insula, suggesting a similar processing of thermal input initiating in the posterior insula, regardless of whether the input produces pain and regardless of thermal modality. In contrast, only thermo-nociceptive stimuli elicited an enhancement of insular GBOs, suggesting that these activities are not simply related to the activation of the spinothalamic system or to the conveyance of thermal information.

Published
2020

24. Sequential targeted exome sequencing of 1001 patients affected by unexplained limb-girdle weakness.

Author

UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/BCHM - Biochimie-Recherche métabolique, UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de neurologie, UCL - (SLuc) Service de neurologie pédiatrique, Töpf, Ana, Johnson, Katherine, Bates, Adam, Phillips, Lauren, Chao, Katherine R, England, Eleina M, Laricchia, Kristen M, Mullen, Thomas, Valkanas, Elise, Xu, Liwen, Bertoli, Marta, Blain, Alison, Casasús, Ana B, Duff, Jennifer, Mroczek, Magdalena, Specht, Sabine, Lek, Monkol, Ensini, Monica, MacArthur, Daniel G, MYO-SEQ consortium, Straub, Volker, Paquay, Stéphanie, Van den Bergh, Peter, Van Parys, Vinciane, UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/BCHM - Biochimie-Recherche métabolique, UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de neurologie, UCL - (SLuc) Service de neurologie pédiatrique, Töpf, Ana, Johnson, Katherine, Bates, Adam, Phillips, Lauren, Chao, Katherine R, England, Eleina M, Laricchia, Kristen M, Mullen, Thomas, Valkanas, Elise, Xu, Liwen, Bertoli, Marta, Blain, Alison, Casasús, Ana B, Duff, Jennifer, Mroczek, Magdalena, Specht, Sabine, Lek, Monkol, Ensini, Monica, MacArthur, Daniel G, MYO-SEQ consortium, Straub, Volker, Paquay, Stéphanie, Van den Bergh, Peter, and Van Parys, Vinciane

Abstract

PURPOSE: Several hundred genetic muscle diseases have been described, all of which are rare. Their clinical and genetic heterogeneity means that a genetic diagnosis is challenging. We established an international consortium, MYO-SEQ, to aid the work-ups of muscle disease patients and to better understand disease etiology. METHODS: Exome sequencing was applied to 1001 undiagnosed patients recruited from more than 40 neuromuscular disease referral centers; standardized phenotypic information was collected for each patient. Exomes were examined for variants in 429 genes associated with muscle conditions. RESULTS: We identified suspected pathogenic variants in 52% of patients across 87 genes. We detected 401 novel variants, 116 of which were recurrent. Variants in CAPN3, DYSF, ANO5, DMD, RYR1, TTN, COL6A2, and SGCA collectively accounted for over half of the solved cases; while variants in newer disease genes, such as BVES and POGLUT1, were also found. The remaining well-characterized unsolved patients (48%) need further investigation. CONCLUSION: Using our unique infrastructure, we developed a pathway to expedite muscle disease diagnoses. Our data suggest that exome sequencing should be used for pathogenic variant detection in patients with suspected genetic muscle diseases, focusing first on the most common disease genes described here, and subsequently in rarer and newly characterized disease genes.

Published
2020

25. Vestibular Infant Screening (VIS)-Flanders: results after 1.5 years of vestibular screening in hearing-impaired children.

Author

UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'oto-rhino-laryngologie, Martens, Sarie, Dhooge, Ingeborg, Dhondt, Cleo, Vanaudenaerde, Saartje, Sucaet, Marieke, Rombaut, Lotte, Boudewyns, An, Desloovere, Christian, Janssens de Varebeke, Sebastien, Vinck, Anne-Sophie, Vanspauwen, Robby, Verschueren, Dominique, Foulon, Ina, Staelens, Charlotte, Van den Broeck, Karen, De Valck, Claudia, Deggouj, Naima, Lemkens, Nele, Haverbeke, Lisa, De Bock, Mieke, Öz, Okan, Declau, Frank, Devroede, Benoit, Verhoye, Christoph, Maes, Leen, UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'oto-rhino-laryngologie, Martens, Sarie, Dhooge, Ingeborg, Dhondt, Cleo, Vanaudenaerde, Saartje, Sucaet, Marieke, Rombaut, Lotte, Boudewyns, An, Desloovere, Christian, Janssens de Varebeke, Sebastien, Vinck, Anne-Sophie, Vanspauwen, Robby, Verschueren, Dominique, Foulon, Ina, Staelens, Charlotte, Van den Broeck, Karen, De Valck, Claudia, Deggouj, Naima, Lemkens, Nele, Haverbeke, Lisa, De Bock, Mieke, Öz, Okan, Declau, Frank, Devroede, Benoit, Verhoye, Christoph, and Maes, Leen

Abstract

Due to the close anatomical relationship between the auditory and vestibular end organs, hearing-impaired children have a higher risk for vestibular dysfunction, which can affect their (motor) development. Unfortunately, vestibular dysfunction often goes unnoticed, as vestibular assessment in these children is not standard of care nowadays. To timely detect vestibular dysfunction, the Vestibular Infant Screening-Flanders (VIS-Flanders) project has implemented a basic vestibular screening test for hearing-impaired infants in Flanders (Belgium) with a participation rate of 86.7% during the first year and a half. The cervical Vestibular Evoked Myogenic Potentials (cVEMP) test was applied as vestibular screening tool to map the occurrence of vestibular (mainly saccular) dysfunction in this population. At the age of 6 months, 184 infants were screened. No refers on vestibular screening were observed in infants with permanent conductive hearing loss. In infants with permanent sensorineural hearing loss, a cVEMP refer rate of 9.5% was observed. Failure was significantly more common in infants with severe-profound compared to those with mild-moderate sensorineural hearing loss (risk ratio = 9.8). Since this is the first regional study with a large sample size and successful participation rate, the VIS-Flanders project aims to set an example for other regions worldwide.

Published
2020

26. Cntn4, a risk gene for neuropsychiatric disorders, modulates hippocampal synaptic plasticity and behavior

Author

TN Onderwijs, AIOS Psychiatrie, Translational Neuroscience, Brain, TN groep Joëls, TN groep Hol, Oguro-Ando, Asami, Bamford, Rosemary A., Sital, Wiedjai, Sprengers, Jan J., Zuko, Amila, Matser, Jolien M., Oppelaar, Hugo, Sarabdjitsingh, Angela, Joëls, Marian, Burbach, J. Peter H., Kas, Martien J., TN Onderwijs, AIOS Psychiatrie, Translational Neuroscience, Brain, TN groep Joëls, TN groep Hol, Oguro-Ando, Asami, Bamford, Rosemary A., Sital, Wiedjai, Sprengers, Jan J., Zuko, Amila, Matser, Jolien M., Oppelaar, Hugo, Sarabdjitsingh, Angela, Joëls, Marian, Burbach, J. Peter H., and Kas, Martien J.

Published
2021

29. A network approach to the five-facet model of mindfulness

Author

UCL - SSH/IPSY - Psychological Sciences Research Institute, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Heeren, Alexandre, Lannoy, Séverine, Coussement, Charlotte, Hoebeke, Yorgo, Verschuren, Alice, Blanchard, Annelise, Chakroun-Baggioni, Nadia, Philippot, Pierre, Gierski, Fabien, UCL - SSH/IPSY - Psychological Sciences Research Institute, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Heeren, Alexandre, Lannoy, Séverine, Coussement, Charlotte, Hoebeke, Yorgo, Verschuren, Alice, Blanchard, Annelise, Chakroun-Baggioni, Nadia, Philippot, Pierre, and Gierski, Fabien

Abstract

Despite the large-scale dissemination of mindfulness-based interventions, debates persist about the very nature of mindfulness. To date, one of the dominant views is the five-facet approach, which suggests that mindfulness includes five facets (i.e., Observing, Describing, Nonjudging, Nonreactivity, and Acting with Awareness). However, uncertainty remains regarding the potential interplay between these facets. In this study, we investigated the five-facet model via network analysis in an unselected sample (n = 1704). We used two distinct computational network approaches: a Gaussian graphical model (i.e., undirected) and a directed acyclic graph, with each model determining the relations between the facets and their relative importance in the network. Both computational approaches pointed to the facet denoting Acting with Awareness as playing an especially potent role in the network system. Altogether, our findings offer novel data-driven clues for the field's larger quest to ascertain the very foundations of mindfulness.

Published
2021

30. Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Author

Neurologen, AIOS Psychiatrie, Neurogenetica, Genetica Klinische Genetica, Opleiding Neurologie, Brain, Hersenen-Bedrijfsvoering, Translational Neuroscience, Regenerative Medicine and Stem Cells, Projectafdeling ALS, SLALOM Consortium, Neurologen, AIOS Psychiatrie, Neurogenetica, Genetica Klinische Genetica, Opleiding Neurologie, Brain, Hersenen-Bedrijfsvoering, Translational Neuroscience, Regenerative Medicine and Stem Cells, Projectafdeling ALS, and SLALOM Consortium

Published
2021

31. Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine

Author

Public Health Practice, Medical Humanities Onderzoek Team 2, Child Health, Regenerative Medicine and Stem Cells, JC onderzoeksprogramma Methodologie, CMM Sectie Molecular Cancer Research, Cancer, Hubrecht Institute with UMC, Onderzoek, Brain, Translational Neuroscience, LifeTime Community Working Groups, Public Health Practice, Medical Humanities Onderzoek Team 2, Child Health, Regenerative Medicine and Stem Cells, JC onderzoeksprogramma Methodologie, CMM Sectie Molecular Cancer Research, Cancer, Hubrecht Institute with UMC, Onderzoek, Brain, Translational Neuroscience, and LifeTime Community Working Groups

Published
2021

32. A directional 3D neurite outgrowth model for studying motor axon biology and disease

Author

Translational Neuroscience, Brain, Regenerative Medicine and Stem Cells, Spijkers, Xandor M., Pasteuning-Vuhman, Svetlana, Dorleijn, Jennifa C., Vulto, Paul, Wevers, Nienke R., Pasterkamp, R. Jeroen, Translational Neuroscience, Brain, Regenerative Medicine and Stem Cells, Spijkers, Xandor M., Pasteuning-Vuhman, Svetlana, Dorleijn, Jennifa C., Vulto, Paul, Wevers, Nienke R., and Pasterkamp, R. Jeroen

Published
2021

33. Reactive astrocyte nomenclature, definitions, and future directions

Author

Translational Neuroscience, Brain, Cancer, Escartin, Carole, Galea, Elena, Lakatos, András, O’Callaghan, James P., Petzold, Gabor C., Serrano-Pozo, Alberto, Steinhäuser, Christian, Volterra, Andrea, Carmignoto, Giorgio, Agarwal, Amit, Allen, Nicola J., Araque, Alfonso, Barbeito, Luis, Barzilai, Ari, Bergles, Dwight E., Bonvento, Gilles, Butt, Arthur M., Chen, Wei Ting, Cohen-Salmon, Martine, Cunningham, Colm, Deneen, Benjamin, De Strooper, Bart, Díaz-Castro, Blanca, Farina, Cinthia, Freeman, Marc, Gallo, Vittorio, Goldman, James E., Goldman, Steven A., Götz, Magdalena, Gutiérrez, Antonia, Haydon, Philip G., Heiland, Dieter H., Hol, Elly M., Holt, Matthew G., Iino, Masamitsu, Kastanenka, Ksenia V., Kettenmann, Helmut, Khakh, Baljit S., Koizumi, Schuichi, Lee, C. Justin, Liddelow, Shane A., MacVicar, Brian A., Magistretti, Pierre, Messing, Albee, Mishra, Anusha, Molofsky, Anna V., Murai, Keith K., Norris, Christopher M., Okada, Seiji, Oliet, Stéphane H.R., Oliveira, João F., Panatier, Aude, Parpura, Vladimir, Pekna, Marcela, Pekny, Milos, Pellerin, Luc, Perea, Gertrudis, Pérez-Nievas, Beatriz G., Pfrieger, Frank W., Poskanzer, Kira E., Quintana, Francisco J., Ransohoff, Richard M., Riquelme-Perez, Miriam, Robel, Stefanie, Rose, Christine R., Rothstein, Jeffrey D., Rouach, Nathalie, Rowitch, David H., Semyanov, Alexey, Sirko, Swetlana, Sontheimer, Harald, Swanson, Raymond A., Vitorica, Javier, Wanner, Ina Beate, Wood, Levi B., Wu, Jiaqian, Zheng, Binhai, Zimmer, Eduardo R., Zorec, Robert, Sofroniew, Michael V., Verkhratsky, Alexei, Translational Neuroscience, Brain, Cancer, Escartin, Carole, Galea, Elena, Lakatos, András, O’Callaghan, James P., Petzold, Gabor C., Serrano-Pozo, Alberto, Steinhäuser, Christian, Volterra, Andrea, Carmignoto, Giorgio, Agarwal, Amit, Allen, Nicola J., Araque, Alfonso, Barbeito, Luis, Barzilai, Ari, Bergles, Dwight E., Bonvento, Gilles, Butt, Arthur M., Chen, Wei Ting, Cohen-Salmon, Martine, Cunningham, Colm, Deneen, Benjamin, De Strooper, Bart, Díaz-Castro, Blanca, Farina, Cinthia, Freeman, Marc, Gallo, Vittorio, Goldman, James E., Goldman, Steven A., Götz, Magdalena, Gutiérrez, Antonia, Haydon, Philip G., Heiland, Dieter H., Hol, Elly M., Holt, Matthew G., Iino, Masamitsu, Kastanenka, Ksenia V., Kettenmann, Helmut, Khakh, Baljit S., Koizumi, Schuichi, Lee, C. Justin, Liddelow, Shane A., MacVicar, Brian A., Magistretti, Pierre, Messing, Albee, Mishra, Anusha, Molofsky, Anna V., Murai, Keith K., Norris, Christopher M., Okada, Seiji, Oliet, Stéphane H.R., Oliveira, João F., Panatier, Aude, Parpura, Vladimir, Pekna, Marcela, Pekny, Milos, Pellerin, Luc, Perea, Gertrudis, Pérez-Nievas, Beatriz G., Pfrieger, Frank W., Poskanzer, Kira E., Quintana, Francisco J., Ransohoff, Richard M., Riquelme-Perez, Miriam, Robel, Stefanie, Rose, Christine R., Rothstein, Jeffrey D., Rouach, Nathalie, Rowitch, David H., Semyanov, Alexey, Sirko, Swetlana, Sontheimer, Harald, Swanson, Raymond A., Vitorica, Javier, Wanner, Ina Beate, Wood, Levi B., Wu, Jiaqian, Zheng, Binhai, Zimmer, Eduardo R., Zorec, Robert, Sofroniew, Michael V., and Verkhratsky, Alexei

Published
2021

34. Systemic delivery of antagomirs during blood-brain barrier disruption is disease-modifying in experimental epilepsy

Author

TN groep Pasterkamp, Brain, Translational Neuroscience, Regenerative Medicine and Stem Cells, Reschke, Cristina R., Silva, Luiz F.A., Vangoor, Vamshidhar R., Rosso, Massimo, David, Bastian, Cavanagh, Brenton L., Connolly, Niamh M.C., Brennan, Gary P., Sanz-Rodriguez, Amaya, Mooney, Catherine, Batool, Aasia, Greene, Chris, Brennan, Marian, Conroy, Ronan M., Rüber, Theodor, Prehn, Jochen H.M., Campbell, Matthew, Pasterkamp, R. Jeroen, Henshall, David C., TN groep Pasterkamp, Brain, Translational Neuroscience, Regenerative Medicine and Stem Cells, Reschke, Cristina R., Silva, Luiz F.A., Vangoor, Vamshidhar R., Rosso, Massimo, David, Bastian, Cavanagh, Brenton L., Connolly, Niamh M.C., Brennan, Gary P., Sanz-Rodriguez, Amaya, Mooney, Catherine, Batool, Aasia, Greene, Chris, Brennan, Marian, Conroy, Ronan M., Rüber, Theodor, Prehn, Jochen H.M., Campbell, Matthew, Pasterkamp, R. Jeroen, and Henshall, David C.

Published
2021

35. Distinct non-inflammatory signature of microglia in post-mortem brain tissue of patients with major depressive disorder

Author

AIOS Psychiatrie, TN groep Pasterkamp, Onderzoeksgroep 2, Brain, Psychiatrie_Medisch, Translational Neuroscience, Cancer, TN groep Hol, Onderzoeksgroep 11, MMB Research line 3b, Psychiatric Donor Program of the Netherlands Brain Bank (NBB-Psy), AIOS Psychiatrie, TN groep Pasterkamp, Onderzoeksgroep 2, Brain, Psychiatrie_Medisch, Translational Neuroscience, Cancer, TN groep Hol, Onderzoeksgroep 11, MMB Research line 3b, and Psychiatric Donor Program of the Netherlands Brain Bank (NBB-Psy)

Published
2021

36. Habituation of phase-locked local field potentials and gamma-band oscillations recorded from the human insula.

Author

UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, UCL - (SLuc) Service de neurochirurgie, UCL - (SLuc) Service de neurologie, Liberati, Giulia, Algoet, Maxime, Klöcker, Anne, Ferrao Santos, Susana, Ribeiro Vaz, José Géraldo, Raftopoulos, Christian, Mouraux, André, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, UCL - (SLuc) Service de neurochirurgie, UCL - (SLuc) Service de neurologie, Liberati, Giulia, Algoet, Maxime, Klöcker, Anne, Ferrao Santos, Susana, Ribeiro Vaz, José Géraldo, Raftopoulos, Christian, and Mouraux, André

Abstract

Salient nociceptive and non-nociceptive stimuli elicit low-frequency local field potentials (LFPs) in the human insula. Nociceptive stimuli also elicit insular gamma-band oscillations (GBOs), possibly preferential for thermonociception, which have been suggested to reflect the intensity of perceived pain. To shed light on the functional significance of these two responses, we investigated whether they would be modulated by stimulation intensity and temporal expectation - two factors contributing to stimulus saliency. Insular activity was recorded from 8 depth electrodes (41 contacts) implanted in the left insula of 6 patients investigated for epilepsy. Thermonociceptive, vibrotactile, and auditory stimuli were delivered using two intensities. To investigate the effects of temporal expectation, the stimuli were delivered in trains of three identical stimuli (S1-S2-S3) separated by a constant 1-s interval. Stimulation intensity affected intensity of perception, the magnitude of low-frequency LFPs, and the magnitude of nociceptive GBOs. Stimulus repetition did not affect perception. In contrast, both low-frequency LFPs and nociceptive GBOs showed a marked habituation of the responses to S2 and S3 as compared to S1 and, hence, a dissociation with intensity of perception. Most importantly, although insular nociceptive GBOs appear to be preferential for thermonociception, they cannot be considered as a correlate of perceived pain.

Published
2018

37. Deficient inhibition in alcohol-dependence: let's consider the role of the motor system!

Author

UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de psychiatrie adulte, UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, UCL - SSH/IPSY - Psychological Sciences Research Institute, Quoilin, Caroline, Wilhelm, Emmanuelle, Maurage, Pierre, de Timary, Philippe, Duque, Julie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de psychiatrie adulte, UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, UCL - SSH/IPSY - Psychological Sciences Research Institute, Quoilin, Caroline, Wilhelm, Emmanuelle, Maurage, Pierre, de Timary, Philippe, and Duque, Julie

Abstract

Impaired inhibitory control contributes to the development, maintenance, and relapse of alcohol-dependence, but the neural correlates of this deficit are still unclear. Because inhibitory control has been labeled as an executive function, most studies have focused on prefrontal areas, overlooking the contribution of more "primary" structures, such as the motor system. Yet, appropriate neural inhibition of the motor output pathway has emerged as a central aspect of healthy behavior. Here, we tested the hypothesis that this motor inhibition is altered in alcohol-dependence. Neural inhibitory measures of motor activity were obtained in 20 detoxified alcohol-dependent (AD) patients and 20 matched healthy subjects, using a standard transcranial magnetic stimulation procedure whereby motor-evoked potentials (MEPs) are elicited in a choice reaction time task. Moreover, behavioral inhibition and trait impulsivity were evaluated in all participants. Finally, the relapse status of patients was assessed 1 year after the experiment. As expected, AD patients displayed poorer behavioral inhibition and higher trait impulsivity than controls. More importantly, the MEP data revealed a considerable shortage of neural motor inhibition in AD patients. Interestingly, this neural defect was strongest in the patients who ended up relapsing during the year following the experiment. Our data suggest a strong motor component in the neural correlates of altered inhibitory control in AD patients. They also highlight an intriguing relationship with relapse and the perspective of a new biomarker to follow strategies aiming at reducing relapse in AD patients.

Published
2018

38. Locus Coeruleus atrophy doesn't relate to fatigue in Parkinson's disease.

Author

UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de médecine physique et de réadaptation motrice, UCL - (SLuc) Service de neurologie, Solopchuk, Oleg, Sebti, Moustapha, Bouvy, Céline, Benoît, Charles-Etienne, Warlop, Thibault, Jeanjean, Anne, Zenon, Alexandre, UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de médecine physique et de réadaptation motrice, UCL - (SLuc) Service de neurologie, Solopchuk, Oleg, Sebti, Moustapha, Bouvy, Céline, Benoît, Charles-Etienne, Warlop, Thibault, Jeanjean, Anne, and Zenon, Alexandre

Abstract

Fatigue is a frequent complaint among healthy population and one of the earliest and most debilitating symptoms in Parkinson's disease (PD). Earlier studies have examined the role of dopamine and serotonin in pathogenesis of fatigue, but the plausible role of noradrenalin (NA) remains underexplored. We investigated the relationship between fatigue in Parkinsonian patients and the extent of degeneration of Locus Coeruleus (LC), the main source of NA in the brain. We quantified LC and Substantia Nigra (SN) atrophy using neuromelanin-sensitive imaging, analyzed with a novel, fully automated algorithm. We also assessed patients' fatigue, depression, sleep disturbance and vigilance. We found that LC degeneration correlated with the levels of depression and vigilance but not with fatigue, while fatigue correlated weakly with atrophy of SN. These results indicate that LC degeneration in Parkinson's disease is unlikely to cause fatigue, but may be involved in mood and vigilance alterations.

Published
2018

39. Detrimental effects of the 'bath salt' methylenedioxypyrovalerone on social play behavior in male rats

Author

AISS Behaviour Neuroscience, dASS BW-1, Behaviour & Welfare, Schiavi, Sara, Melancia, Francesca, Carbone, Emilia, Buzzelli, Valeria, Manduca, Antonia, Peinado, Patricia Jiménez, Zwergel, Clemens, Mai, Antonello, Campolongo, Patrizia, Vanderschuren, Louk J M J, Trezza, Viviana, AISS Behaviour Neuroscience, dASS BW-1, Behaviour & Welfare, Schiavi, Sara, Melancia, Francesca, Carbone, Emilia, Buzzelli, Valeria, Manduca, Antonia, Peinado, Patricia Jiménez, Zwergel, Clemens, Mai, Antonello, Campolongo, Patrizia, Vanderschuren, Louk J M J, and Trezza, Viviana

Published
2020

41. Mechanisms of stretch-mediated skin expansion at single-cell resolution.

Author

UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, Aragona, Mariaceleste, Sifrim, Alejandro, Malfait, Milan, Song, Yura, Van Herck, Jens, Dekoninck, Sophie, Gargouri, Souhir, Lapouge, Gaëlle, Swedlund, Benjamin, Dubois, Christine, Baatsen, Pieter, Vints, Katlijn, Han, Seungmin, Tissir, Fadel, Voet, Thierry, Simons, Benjamin D, Blanpain, Cédric, UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, Aragona, Mariaceleste, Sifrim, Alejandro, Malfait, Milan, Song, Yura, Van Herck, Jens, Dekoninck, Sophie, Gargouri, Souhir, Lapouge, Gaëlle, Swedlund, Benjamin, Dubois, Christine, Baatsen, Pieter, Vints, Katlijn, Han, Seungmin, Tissir, Fadel, Voet, Thierry, Simons, Benjamin D, and Blanpain, Cédric

Abstract

The ability of the skin to grow in response to stretching has been exploited in reconstructive surgery. Although the response of epidermal cells to stretching has been studied in vitro, it remains unclear how mechanical forces affect their behaviour in vivo. Here we develop a mouse model in which the consequences of stretching on skin epidermis can be studied at single-cell resolution. Using a multidisciplinary approach that combines clonal analysis with quantitative modelling and single-cell RNA sequencing, we show that stretching induces skin expansion by creating a transient bias in the renewal activity of epidermal stem cells, while a second subpopulation of basal progenitors remains committed to differentiation. Transcriptional and chromatin profiling identifies how cell states and gene-regulatory networks are modulated by stretching. Using pharmacological inhibitors and mouse mutants, we define the step-by-step mechanisms that control stretch-mediated tissue expansion at single-cell resolution in vivo.

Published
2020

42. Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease

Author

TN groep Adan, Brain, Translational Neuroscience, Neurogenetica, Circulatory Health, Onderzoek, Arts-assistenten Kinderen, Eating Disorders Working Group of the Psychiatric Genomics Consortium, International Headache Genetics Consortium, 23andMe Research Team, TN groep Adan, Brain, Translational Neuroscience, Neurogenetica, Circulatory Health, Onderzoek, Arts-assistenten Kinderen, Eating Disorders Working Group of the Psychiatric Genomics Consortium, International Headache Genetics Consortium, and 23andMe Research Team

Published
2020

43. Nolz1 expression is required in dopaminergic axon guidance and striatal innervation

Author

TN groep Pasterkamp, Brain, Translational Neuroscience, Regenerative Medicine and Stem Cells, Soleilhavoup, Clement, Travaglio, Marco, Patrick, Kieran, Garção, Pedro, Boobalan, Elangovan, Adolfs, Youri, Spriggs, Ruth V., Moles-Garcia, Emma, Dhiraj, Dalbir, Oosterveen, Tony, Ferri, Sarah L., Abel, Ted, Brodkin, Edward S., Pasterkamp, R. Jeroen, Brooks, Brian P., Panman, Lia, TN groep Pasterkamp, Brain, Translational Neuroscience, Regenerative Medicine and Stem Cells, Soleilhavoup, Clement, Travaglio, Marco, Patrick, Kieran, Garção, Pedro, Boobalan, Elangovan, Adolfs, Youri, Spriggs, Ruth V., Moles-Garcia, Emma, Dhiraj, Dalbir, Oosterveen, Tony, Ferri, Sarah L., Abel, Ted, Brodkin, Edward S., Pasterkamp, R. Jeroen, Brooks, Brian P., and Panman, Lia

Published
2020

44. Predictors of risky foraging behaviour in healthy young people

Author

Bach, Dominik R; https://orcid.org/0000-0003-3717-2036, Moutoussis, Michael; https://orcid.org/0000-0002-4751-0425, Bowler, Aislinn; https://orcid.org/0000-0002-7011-405X, Neuroscience in Psychiatry Network consortium, Dolan, Raymond J; https://orcid.org/0000-0001-9356-761X, Bach, Dominik R; https://orcid.org/0000-0003-3717-2036, Moutoussis, Michael; https://orcid.org/0000-0002-4751-0425, Bowler, Aislinn; https://orcid.org/0000-0002-7011-405X, Neuroscience in Psychiatry Network consortium, and Dolan, Raymond J; https://orcid.org/0000-0001-9356-761X

Abstract

During adolescence and early adulthood, learning when to avoid threats and when to pursue rewards becomes crucial. Using a risky foraging task, we investigated individual differences in this dynamic across 781 individuals aged 14-24 years who were split into a hypothesis-generating discovery sample and a hold-out confirmation sample. Sex was the most important predictor of cautious behaviour and performance. Males earned one standard deviation (or 20%) more reward than females, collected more reward when there was little to lose and reduced foraging to the same level as females when potential losses became high. Other independent predictors of cautiousness and performance were self-reported daringness, IQ and self-reported cognitive complexity. We found no evidence for an impact of age or maturation. Thus, maleness, a high IQ or self-reported cognitive complexity, and self-reported daringness predicted greater success in risky foraging, possibly due to better exploitation of low-risk opportunities in high-risk environments.

Published
2020

45. Oxytocin attenuates phencyclidine hyperactivity and increases social interaction and nucleus accumben dopamine release in rats

Author

Kohli, Shivali, King, Madeleine V., Williams, Stuart, Edwards, Adele, Ballard, Theresa M., Steward, Lucinda J., Alberati, Daniella, Fone, Kevin C.F., University of Nottingham, and F. Hoffmann-La Roche AG, Roche Innovation Centre Basel, Neuroscience Discovery NORD, Grenzacherstrasse 124, Basel, Switzerland, CH4070

Subjects
Male, Vasopressin, medicine.medical_specialty, Microdialysis, Serotonin, Dopamine, Neuropeptide, Phencyclidine, Prefrontal Cortex, Nucleus accumbens, Motor Activity, Oxytocin, Nucleus Accumbens, Article, Body Temperature, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Animals, Social Behavior, Pharmacology, Behavior, Animal, business.industry, 030227 psychiatry, Rats, Psychiatry and Mental health, Monoamine neurotransmitter, Endocrinology, business, Excitatory Amino Acid Antagonists, 030217 neurology & neurosurgery, medicine.drug
Abstract

The pituitary neuropeptide oxytocin promotes social behavior, and is a potential adjunct therapy for social deficits in schizophrenia and autism. Oxytocin may mediate pro-social effects by modulating monoamine release in limbic and cortical areas, which was investigated herein using in vivo microdialysis, after establishing a dose that did not produce accompanying sedative or thermoregulatory effects that could concomitantly influence behavior. The effects of oxytocin (0.03–0.3 mg/kg subcutaneous) on locomotor activity, core body temperature, and social behavior (social interaction and ultrasonic vocalizations) were examined in adult male Lister-hooded rats, using selective antagonists to determine the role of oxytocin and vasopressin V(1a) receptors. Dopamine and serotonin efflux in the prefrontal cortex and nucleus accumbens of conscious rats were assessed using microdialysis. 0.3 mg/kg oxytocin modestly reduced activity and caused hypothermia but only the latter was attenuated by the V(1a) receptor antagonist, SR49059 (1 mg/kg intraperitoneal). Oxytocin at 0.1 mg/kg, which did not alter activity and had little effect on temperature, significantly attenuated phencyclidine-induced hyperactivity and increased social interaction between unfamiliar rats without altering the number or pattern of ultrasonic vocalizations. In the same rats, oxytocin (0.1 mg/kg) selectively elevated dopamine overflow in the nucleus accumbens, but not prefrontal cortex, without influencing serotonin efflux. Systemic oxytocin administration attenuated phencyclidine-induced hyperactivity and increased pro-social behavior without decreasing core body temperature and selectively enhanced nucleus accumbens dopamine release, consistent with activation of mesocorticolimbic circuits regulating associative/reward behavior being involved. This highlights the therapeutic potential of oxytocin to treat social behavioral deficits seen in psychiatric disorders such as schizophrenia.

Published
2018

46. Assessing the utility of Magneto to control neuronal excitability in the somatosensory cortex

Author

Behaviour Neuroscience, Kole, Koen, Zhang, Yiping, Jansen, Eric J R, Brouns, Terence, Bijlsma, Ate, Calcini, Niccolo, Yan, Xuan, Lantyer, Angelica da Silva, Celikel, Tansu, Behaviour Neuroscience, Kole, Koen, Zhang, Yiping, Jansen, Eric J R, Brouns, Terence, Bijlsma, Ate, Calcini, Niccolo, Yan, Xuan, Lantyer, Angelica da Silva, and Celikel, Tansu

Published
2019

48. The reduction of astrocytes and brain volume loss in anorexia nervosa—the impact of starvation and refeeding in a rodent model

Author

Translational Neuroscience, Frintrop, Linda, Trinh, Stefanie, Liesbrock, Johanna, Leunissen, Christina, Kempermann, Julia, Etdöger, Serhat, Kas, Martien J., Tolba, René, Heussen, Nicole, Neulen, Joseph, Konrad, Kerstin, Päfgen, Vera, Kiessling, Fabian, Herpertz-Dahlmann, Beate, Beyer, Cordian, Seitz, Jochen, Translational Neuroscience, Frintrop, Linda, Trinh, Stefanie, Liesbrock, Johanna, Leunissen, Christina, Kempermann, Julia, Etdöger, Serhat, Kas, Martien J., Tolba, René, Heussen, Nicole, Neulen, Joseph, Konrad, Kerstin, Päfgen, Vera, Kiessling, Fabian, Herpertz-Dahlmann, Beate, Beyer, Cordian, and Seitz, Jochen

Published
2019

49. Reproducibility via coordinated standardization: a multi-center study in a S hank2 genetic rat model for Autism Spectrum Disorders

Author

Translational Neuroscience, Arroyo-Araujo, María, Graf, Radka, Maco, Martine, van Dam, Elsbeth, Schenker, Esther, Drinkenburg, Wilhelmus, Koopmans, Bastijn, de Boer, Sietse F., Cullum-Doyle, Michaela, Noldus, Lucas P.J.J., Loos, Maarten, van Dommelen, Wil, Spooren, Will, Biemans, Barbara, Buhl, Derek L., Kas, Martien J., Translational Neuroscience, Arroyo-Araujo, María, Graf, Radka, Maco, Martine, van Dam, Elsbeth, Schenker, Esther, Drinkenburg, Wilhelmus, Koopmans, Bastijn, de Boer, Sietse F., Cullum-Doyle, Michaela, Noldus, Lucas P.J.J., Loos, Maarten, van Dommelen, Wil, Spooren, Will, Biemans, Barbara, Buhl, Derek L., and Kas, Martien J.

Published
2019

50. Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

Author

TN groep Adan, Brain, Circulatory Health, Translational Neuroscience, Hersenen-Bedrijfsvoering, Neurogenetica, Watson, Hunna J, Yilmaz, Zeynep, Thornton, Laura M, Hübel, Christopher, Coleman, Jonathan R I, Gaspar, Héléna A, Bryois, Julien, Hinney, Anke, Leppä, Virpi M, Mattheisen, Manuel, Medland, Sarah E, Ripke, Stephan, Yao, Shuyang, Giusti-Rodríguez, Paola, Hanscombe, Ken B, Purves, Kirstin L, Adan, Roger A H, Alfredsson, Lars, Ando, Tetsuya, Andreassen, Ole A, Baker, Jessica H, Berrettini, Wade H, Boehm, Ilka, Boni, Claudette, Perica, Vesna Boraska, Buehren, Katharina, Burghardt, Roland, Cassina, Matteo, Cichon, Sven, Clementi, Maurizio, Cone, Roger D, Courtet, Philippe, Crow, Scott, Crowley, James J, Danner, Unna N, Davis, Oliver S P, de Zwaan, Martina, Dedoussis, George, Degortes, Daniela, DeSocio, Janiece E, Dick, Danielle M, Dikeos, Dimitris, Dina, Christian, Dmitrzak-Weglarz, Monika, Docampo, Elisa, Duncan, Laramie E, Egberts, Karin, Kas, Martien J H, Lin, Bochao Danae, Ophoff, Roel A, Luykx, Jurjen, Anorexia Nervosa Genetics Initiative, TN groep Adan, Brain, Circulatory Health, Translational Neuroscience, Hersenen-Bedrijfsvoering, Neurogenetica, Watson, Hunna J, Yilmaz, Zeynep, Thornton, Laura M, Hübel, Christopher, Coleman, Jonathan R I, Gaspar, Héléna A, Bryois, Julien, Hinney, Anke, Leppä, Virpi M, Mattheisen, Manuel, Medland, Sarah E, Ripke, Stephan, Yao, Shuyang, Giusti-Rodríguez, Paola, Hanscombe, Ken B, Purves, Kirstin L, Adan, Roger A H, Alfredsson, Lars, Ando, Tetsuya, Andreassen, Ole A, Baker, Jessica H, Berrettini, Wade H, Boehm, Ilka, Boni, Claudette, Perica, Vesna Boraska, Buehren, Katharina, Burghardt, Roland, Cassina, Matteo, Cichon, Sven, Clementi, Maurizio, Cone, Roger D, Courtet, Philippe, Crow, Scott, Crowley, James J, Danner, Unna N, Davis, Oliver S P, de Zwaan, Martina, Dedoussis, George, Degortes, Daniela, DeSocio, Janiece E, Dick, Danielle M, Dikeos, Dimitris, Dina, Christian, Dmitrzak-Weglarz, Monika, Docampo, Elisa, Duncan, Laramie E, Egberts, Karin, Kas, Martien J H, Lin, Bochao Danae, Ophoff, Roel A, Luykx, Jurjen, and Anorexia Nervosa Genetics Initiative

Published
2019

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