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The mechanical muscular oscillations are rarely the objective of investigations regarding the identification of a biomarker for Parkinson's disease (PD). Therefore, the aim of this study was to investigate whether or not this specific motor output differs between PD patients and controls. The novelty is that patients without tremor are investigated performing a unilateral isometric motor task. The force of armflexors and the forearm acceleration (ACC) were recorded as well as the mechanomyography of the biceps brachii (MMGbi), brachioradialis (MMGbra) and pectoralis major (MMGpect) muscles using a piezoelectric-sensor-based system during a unilateral motor task at 70% of the MVIC. The frequency, a power-frequency-ratio, the amplitude variation, the slope of amplitudes and their interlimb asymmetries were analysed. The results indicate that the oscillatory behavior of muscular output in PD without tremor deviates from controls in some parameters: Significant differences appeared for the power-frequency-ratio (p = 0.001, r = 0.43) and for the amplitude variation (p = 0.003, r = 0.34) of MMGpect. The interlimb asymmetries differed significantly concerning the power-frequency-ratio of MMGbi (p = 0.013, r = 0.42) and MMGbra (p = 0.048, r = 0.39) as well as regarding the mean frequency (p = 0.004, r = 0.48) and amplitude variation of MMGpect (p = 0.033, r = 0.37). The mean (M) and variation coefficient (CV) of slope of ACC differed significantly (M: p = 0.022, r = 0.33; CV: p = 0.004, r = 0.43). All other parameters showed no significant differences between PD and controls. It remains open, if this altered mechanical muscular output is reproducible and specific for PD.

Reconstructing long-term continental temperature change provides the required counterpart to age equivalent marine records and can reveal how terrestrial and marine temperatures were related during times of extreme climate change such as the Miocene Climatic Optimum (MCO) and the following Middle Miocene Climatic Transition (MMCT). Carbonate clumped isotope temperatures (T(Δ 47 )) from 17.5 to 14.0 Ma Central European paleosols (Molasse Basin, Switzerland) display a temperature pattern during the MCO that is similar to coeval marine temperature records. Maximum temperatures in the long-term soil T(Δ 47 ) record (at 16.5 and 14.9 Ma) lag maximum ocean bottom water temperatures, lead global ice volume, and mark the initiation of minimum global ice volume phases. The suggested onset of the MMCT, deduced by a marked and rapid decline in Molasse Basin soil temperatures is coeval with cooling reported in high-latitudinal marine records. This is best explained by a change in the seasonal timing of soil carbonate formation that was likely driven by a modification of rainfall seasonality and thus by a major reorganization of mid-latitude atmospheric circulation across Central Europe. In particular, our data suggest a strong climate coupling between the North Atlantic and Central Europe already in the middle Miocene.

Brachiopod shells are the most widely used geological archive for the reconstruction of the temperature and the oxygen isotope composition of Phanerozoic seawater. However, it is not conclusive whether brachiopods precipitate their shells in thermodynamic equilibrium. In this study, we investigated the potential impact of kinetic controls on the isotope composition of modern brachiopods by measuring the oxygen and clumped isotope compositions of their shells. Our results show that clumped and oxygen isotope compositions depart from thermodynamic equilibrium due to growth rate-induced kinetic effects. These departures are in line with incomplete hydration and hydroxylation of dissolved CO 2 . These findings imply that the determination of taxon-specific growth rates alongside clumped and bulk oxygen isotope analyses is essential to ensure accurate estimates of past ocean temperatures and seawater oxygen isotope compositions from brachiopods.