1. The Collaborative Cross, a community resource for the genetic analysis of complex traits
- Author
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Linda D. Siracusa, Bastien Llamas, Lisa M. Tarantino, William Valdar, Aldons J. Lusis, Siming Shou, Fuad A. Iraqi, Dabao Zhang, Alexander V. Osadchuk, Frank Lammert, Heinz Himmelbauer, Boris Ivandic, Zonghua Qi, Daniel R. Prows, Willam D. Beavis, Kari J. Buck, Pedro R. Lowenstein, Ariel Darvasi, Fei Zou, Leena Peltonen-Palotie, J. M. Lassalle, James M. Cheverud, Roger H. Reeves, Karen L. Svenson, Howard K. Gershenfeld, Molly A. Bogue, Hans-Willem Snoeck, Nancy L. Hayes, John C. Roder, Karl J. Jepsen, Guy Mittleman, Robert Hitzemann, Howard J. Jacob, Jiri Forejt, Juan F. Medrano, Craig Heller, Richard Mott, Joe M. Angel, Gerald de Haan, Fernando Pardo-Manuel de Villena, Michal Pravenec, Grant Morahan, Kenneth F. Manly, Beverly Paigen, Weikuan Gu, Steve Whatley, Glenn D. Rosen, Kent W. Hunter, Gerd Kempermann, Christina Kendziorski, Margit Burmeister, Jing Gu, Hui-Chen Hsu, Hooman Allayee, Steven J. Clapcote, R. Frank Kooy, Christian F. Deschepper, Linda A. Toth, Rebecca W. Doerge, Ritsert C. Jansen, Ralph S. Marcucio, Steven J. Garlow, John C. Crabbe, Elissa J. Chesler, Beth Bennett, André Bleich, Nengjun Yi, Tom Wiltshire, Kazuhiro Shimomura, Roger D. Cox, Wim E. Crusio, Lu Lu, Hiroki Nagase, Joseph H. Nadeau, Doug Matthews, Leonard C. Schalkwyk, Jeremy L. Peirce, Dabney K. Johnson, Richard S. Nowakowski, Jackson Beatty, Terry Gordon, Beverly A. Mock, Eric E. Schadt, David C. Airey, Wade H. Berrettini, Charles R. Farber, Mikko J. Sillanpää, Xavier Montagutelli, Gary A. Churchill, Jimmy L. Spearow, Daniel Gaile, Darla R. Miller, Huei Ju Pan, Grier P. Page, Melloni N. Cook, Malak Kotb, Thomas E. Johnson, Min Zhang, Karl W. Broman, Hartmut Geiger, David G. Morris, Ze'ev Seltzer, Craig H Warden, Alan D. Attie, Edward S. Buckler, Abraham A. Palmer, Robert W. Williams, David W. Threadgill, John K. Belknap, Jeffrey S. Mogil, Daniel Pomp, Kenneth Paigen, Bruce F. O'Hara, Faculty of Science and Engineering, Groningen Biomolecular Sciences and Biotechnology, Bioinformatics, Faculteit Medische Wetenschappen/UMCG, and Stem Cell Aging Leukemia and Lymphoma (SALL)
- Subjects
Mice, Inbred Strains ,Disease ,Breeding ,Biology ,Community Networks ,Genetic analysis ,03 medical and health sciences ,Human health ,0302 clinical medicine ,Databases, Genetic ,Genetics ,Animals ,Humans ,Systems genetics ,Crosses, Genetic ,030304 developmental biology ,Recombination, Genetic ,0303 health sciences ,ENVIRONMENT ,business.industry ,STRAINS ,Health services research ,Data science ,Biotechnology ,MICE ,Community resource ,Trait ,Health Resources ,Health Services Research ,business ,030217 neurology & neurosurgery - Abstract
The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background are less effective for studying intact potygenic networks and interactions among genes, environments, pathogens and other factors. The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease.
- Published
- 2004