1. Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma
- Author
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Vithana, EN, Khor, C-C, Qiao, C, Nongpiur, ME, George, R, Chen, L-J, Tan, D, Abu-Amero, KK, Huang, CK, Low, S, Tajudin, L-SA, Perera, SA, Cheng, C-Y, Xu, L, Jia, H, Ho, C-L, Sim, KS, Wu, R-Y, Tham, CCY, Chew, PTK, Su, DH, Oen, FT, Sarangapani, S, Soumittra, N, Osman, EA, Wong, H-T, Tang, G, Fan, S, Meng, H, Huong, DTL, Wang, H, Feng, B, Baskaran, M, Shantha, B, Ramprasad, VL, Kumaramanickavel, G, Iyengar, SK, How, AC, Lee, KY, Sivakumaran, TA, Yong, VHK, Ting, SML, Li, Y, Wang, Y-X, Tay, W-T, Sim, X, Lavanya, R, Cornes, BK, Zheng, Y-F, Wong, TT, Loon, S-C, Yong, VKY, Waseem, N, Yaakub, A, Chia, K-S, Allingham, RR, Hauser, MA, Lam, DSC, Hibberd, ML, Bhattacharya, SS, Zhang, M, Teo, YY, Tan, DT, Jonas, JB, Tai, E-S, Saw, S-M, Do, NH, Al-Obeidan, SA, Liu, J, Tran, NBC, Simmons, CP, Bei, J-X, Zeng, Y-X, Foster, PJ, Vijaya, L, Wong, T-Y, Pang, C-P, Wang, N, Aung, T, Vithana, EN, Khor, C-C, Qiao, C, Nongpiur, ME, George, R, Chen, L-J, Tan, D, Abu-Amero, KK, Huang, CK, Low, S, Tajudin, L-SA, Perera, SA, Cheng, C-Y, Xu, L, Jia, H, Ho, C-L, Sim, KS, Wu, R-Y, Tham, CCY, Chew, PTK, Su, DH, Oen, FT, Sarangapani, S, Soumittra, N, Osman, EA, Wong, H-T, Tang, G, Fan, S, Meng, H, Huong, DTL, Wang, H, Feng, B, Baskaran, M, Shantha, B, Ramprasad, VL, Kumaramanickavel, G, Iyengar, SK, How, AC, Lee, KY, Sivakumaran, TA, Yong, VHK, Ting, SML, Li, Y, Wang, Y-X, Tay, W-T, Sim, X, Lavanya, R, Cornes, BK, Zheng, Y-F, Wong, TT, Loon, S-C, Yong, VKY, Waseem, N, Yaakub, A, Chia, K-S, Allingham, RR, Hauser, MA, Lam, DSC, Hibberd, ML, Bhattacharya, SS, Zhang, M, Teo, YY, Tan, DT, Jonas, JB, Tai, E-S, Saw, S-M, Do, NH, Al-Obeidan, SA, Liu, J, Tran, NBC, Simmons, CP, Bei, J-X, Zeng, Y-X, Foster, PJ, Vijaya, L, Wong, T-Y, Pang, C-P, Wang, N, and Aung, T
- Abstract
Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR)=1.22; P=5.33×10(-12)), rs3753841 in COL11A1 (per-allele OR=1.20; P=9.22×10(-10)) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR=1.50; P=3.29×10(-9)). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG.
- Published
- 2012