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Your search keyword '"Girao, Henrique"' showing total 8 results
Start Over Author "Girao, Henrique" Publisher nature publishing group
8 results on '"Girao, Henrique"'

1. Cardiac fibroblasts and mechanosensation in heart development, health and disease

Author

Onderzoek Cardiovasculair Reg. Med., Circulatory Health, Regenerative Medicine and Stem Cells, Pesce, Maurizio, Duda, Georg N., Forte, Giancarlo, Girao, Henrique, Raya, Angel, Roca-Cusachs, Pere, Sluijter, Joost P.G., Tschöpe, Carsten, Van Linthout, Sophie, Onderzoek Cardiovasculair Reg. Med., Circulatory Health, Regenerative Medicine and Stem Cells, Pesce, Maurizio, Duda, Georg N., Forte, Giancarlo, Girao, Henrique, Raya, Angel, Roca-Cusachs, Pere, Sluijter, Joost P.G., Tschöpe, Carsten, and Van Linthout, Sophie

Published
2023

2. Corrigendum : Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells

Author

Soares, Ana Rosa, Martins-Marques, Tania, Ribeiro-Rodrigues, Teresa, Ferreira, Joao Vasco, Catarino, Steve, Pinho, Maria João, Zuzarte, Monica, Anjo, Sandra Isabel, Manadas, Bruno, Sluijter, Joost P G, Pereira, Paulo, Girao, Henrique, Soares, Ana Rosa, Martins-Marques, Tania, Ribeiro-Rodrigues, Teresa, Ferreira, Joao Vasco, Catarino, Steve, Pinho, Maria João, Zuzarte, Monica, Anjo, Sandra Isabel, Manadas, Bruno, Sluijter, Joost P G, Pereira, Paulo, and Girao, Henrique

Published
2015

3. Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells

Author

Soares, Ana Rosa, Martins-Marques, Tania, Ribeiro-Rodrigues, Teresa, Ferreira, Joao Vasco, Catarino, Steve, Pinho, Maria Joao, Zuzarte, Monica, Anjo, Sandra Isabel, Manadas, Bruno, Sluijter, Joost P. G., Pereira, Paulo, Girao, Henrique, Soares, Ana Rosa, Martins-Marques, Tania, Ribeiro-Rodrigues, Teresa, Ferreira, Joao Vasco, Catarino, Steve, Pinho, Maria Joao, Zuzarte, Monica, Anjo, Sandra Isabel, Manadas, Bruno, Sluijter, Joost P. G., Pereira, Paulo, and Girao, Henrique

Published
2015

4. Corrigendum: Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells

Author

Onderzoek Vrouw Hart & Vaatziekten, Soares, Ana Rosa, Martins-Marques, Tania, Ribeiro-Rodrigues, Teresa, Ferreira, Joao Vasco, Catarino, Steve, Pinho, Maria João, Zuzarte, Monica, Anjo, Sandra Isabel, Manadas, Bruno, Sluijter, Joost P G, Pereira, Paulo, Girao, Henrique, Onderzoek Vrouw Hart & Vaatziekten, Soares, Ana Rosa, Martins-Marques, Tania, Ribeiro-Rodrigues, Teresa, Ferreira, Joao Vasco, Catarino, Steve, Pinho, Maria João, Zuzarte, Monica, Anjo, Sandra Isabel, Manadas, Bruno, Sluijter, Joost P G, Pereira, Paulo, and Girao, Henrique

Published
2015

5. Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells

Author

Onderzoek Vrouw Hart & Vaatziekten, Soares, Ana Rosa, Martins-Marques, Tania, Ribeiro-Rodrigues, Teresa, Ferreira, Joao Vasco, Catarino, Steve, Pinho, Maria Joao, Zuzarte, Monica, Anjo, Sandra Isabel, Manadas, Bruno, Sluijter, Joost P. G., Pereira, Paulo, Girao, Henrique, Onderzoek Vrouw Hart & Vaatziekten, Soares, Ana Rosa, Martins-Marques, Tania, Ribeiro-Rodrigues, Teresa, Ferreira, Joao Vasco, Catarino, Steve, Pinho, Maria Joao, Zuzarte, Monica, Anjo, Sandra Isabel, Manadas, Bruno, Sluijter, Joost P. G., Pereira, Paulo, and Girao, Henrique

Published
2015

7. Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells.

Author

Soares AR, Martins-Marques T, Ribeiro-Rodrigues T, Ferreira JV, Catarino S, Pinho MJ, Zuzarte M, Isabel Anjo S, Manadas B, P G Sluijter J, Pereira P, and Girao H

Subjects
Animals, Body Fluids metabolism, Cells, Cultured, DNA metabolism, Exosomes metabolism, Intracellular Membranes metabolism, Mass Spectrometry, Rats, Wistar, Cell Communication, Connexin 43 metabolism, Extracellular Vesicles metabolism, Gap Junctions metabolism
Abstract

Intercellular communication is vital to ensure tissue and organism homeostasis and can occur directly, between neighbour cells via gap junctions (GJ), or indirectly, at longer distances, through extracellular vesicles, including exosomes. Exosomes, as intercellular carriers of messenger molecules, mediate the transfer of biological information between donor and acceptor cells. Although the biological effects of exosomes in target cells have been intensively studied, the mechanisms that govern exosomal uptake are not fully understood. Here, we show that Connexin 43 (Cx43), the most widely expressed GJ protein, is present in exosomes in the form of hexameric channels and, more importantly, that exosomal Cx43 is able to modulate the interaction and transfer of information between exosomes and acceptor cells. This study envisions a new paradigm where Cx43-containing channels mediate the release of exosomal content into cells, which constitutes a novel and unanticipated mechanism to modulate intercellular communication.

Published
2015
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8. K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy.

Author

Ferreira JV, Soares AR, Ramalho JS, Pereira P, and Girao H

Subjects
Animals, Culture Media, Serum-Free, HSC70 Heat-Shock Proteins metabolism, HeLa Cells, Humans, Lysosomal-Associated Membrane Protein 2 metabolism, Male, Mice, NIH 3T3 Cells, Protein Binding, Rats, Wistar, Ubiquitin-Protein Ligases metabolism, Ubiquitination, Autophagy, Hypoxia-Inducible Factor 1, alpha Subunit metabolism, Lysine metabolism, Molecular Chaperones metabolism, Proteolysis, Ubiquitin metabolism
Abstract

Chaperone-Mediated Autophagy is a selective form of autophagy. Recently, the degradation of a newly identified CMA substrate, the HIF1A transcription factor, was found to be regulated by the ubiquitin ligase STUB1. In this study we show, for the first time, that K63 ubiquitination is necessary for CMA degradation of HIF1A in vitro and in vivo. Additionally, STUB1 mediates K63 linked ubiquitination of HIF1A. Our findings add a new regulatory step and increase the specificity of the molecular mechanism involved in CMA degradation of HIF1A, expanding the role of ubiquitination to yet another biological process, since the same mechanism might be applicable to other CMA substrates.

Published
2015
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