1. Association of LRRK2 R1628P variant with Parkinson’s disease in Ethnic Han-Chinese and subgroup population
- Author
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Fengjuan Jiao, Feng He, Qingzhi Wang, Pei Zhang, Jianguo Yan, Qian Zhang, Li-Jun Chen, and Bo Tian
- Subjects
Male ,0301 basic medicine ,Genotype ,Population ,Ethnic group ,Single-nucleotide polymorphism ,Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 ,Polymorphism, Single Nucleotide ,Article ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,Gene Frequency ,Risk Factors ,Ethnicity ,Humans ,Medicine ,Genetic Predisposition to Disease ,Age of Onset ,Family history ,education ,Allele frequency ,education.field_of_study ,Multidisciplinary ,business.industry ,Case-control study ,Parkinson Disease ,Odds ratio ,Middle Aged ,030104 developmental biology ,Case-Control Studies ,Female ,Age of onset ,business ,030217 neurology & neurosurgery ,Demography - Abstract
Recent studies have linked certain single nucleotide polymorphisms in the leucine-rich repeat kinase 2 (LRRK2) gene with Parkinson’s disease (PD). The R1628P variant of LRRK2 may be a specific risk factor for PD in ethnic Han-Chinese populations. This study is to elucidate the epidemiological feature of R1628P in ethnic Han-Chinese population with PD. A comprehensive meta-analysis was performed to evaluate the precise association between R1628P variant and the risk for PD in ethnic Han-Chinese and subgroups stratified by gender, onset age, or family history. The analysis assessing the role of R1628P on the risk of PD in ethnic Han-Chinese supported a significant association, and the odds ratio was 1.86. We further estimate the specific prevalence in relevant ethnic Han-Chinese subgroups. After stratifying the eligible data by gender, onset age, or family history, significant associations were found in all male, female, early-onset, late-onset, familial and sporadic subgroups, and the odds ratio were 1.90, 1.94, 2.12, 1.75, 6.71 and 1.81 respectively. In conclusion, our meta-analysis suggests that R1628P variant of LRRK2 has a significant association with the risk of PD in ethnic Han-Chinese and subgroup population.
- Published
- 2016
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