1. Bone markers after total body irradiation in childhood.
- Author
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Couto-Silva AC, Trivin C, Espérou H, Michon J, Baruchel A, Souberbielle JC, and Brauner R
- Subjects
- Biomarkers blood, Body Height drug effects, Body Height radiation effects, Bone Development radiation effects, Bone Remodeling drug effects, Bone Remodeling radiation effects, Bone and Bones drug effects, Case-Control Studies, Child, Collagen Type I blood, Growth Disorders blood, Growth Disorders etiology, Hematopoietic Stem Cell Transplantation, Human Growth Hormone therapeutic use, Humans, Osteocalcin blood, Peptide Fragments blood, Peptides blood, Procollagen blood, Recombinant Proteins therapeutic use, Bone and Bones metabolism, Bone and Bones radiation effects, Whole-Body Irradiation adverse effects
- Abstract
Total body irradiation (TBI) can cause short stature because of decreased growth hormone (GH) and skeletal abnormalities. To evaluate the plasma concentrations of markers of bone formation (osteocalcin and procollagen type 1 amino-terminal propeptide, P1NP) and resorption (carboxy-terminal telopeptide, CTX), in patients (n=65) who had been given TBI at 6.6+/-0.4 years were evaluated at 9.8+/-0.4 years. Patients given single 10 Gy or fractionated 12 Gy TBI had similar characteristics, except that plasma insulin-like growth factor (IGF-1) was lower in those given a single 10 Gy. Seven had lower osteocalcin and two had higher CTX than controls. Bone markers (as zs) were positively correlated (osteocalcin with P1NP, rho=0.42, P=0.0007; osteocalcin with CTX, rho=0.3, P<0.02), but not P1NP with CTX. Plasma osteocalcin and CTX were also positively correlated with plasma IGF-1, but not with growth rate during the first year on GH (n=28). Adult height was -2.5+/-0.2 s.d.s. (n=49). Those irradiated when young (P=0.0002) or given single TBI lost more height between TBI and adult height. Most TBI patients had normal bone formation and resorption markers. Thus, impaired bone turnover is probably not the cause of their short stature and poor response to GH.
- Published
- 2010
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