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As a preprocessing for machine learning and data mining, Feature Selection plays an important role. Feature selection aims to streamline high-dimensional data by eliminating irrelevant and redundant features, which reduces the potential curse of dimensionality of a given large dataset. When working with datasets containing many features, algorithms that aim to identify the most valuable features to improve dataset accuracy may encounter difficulties because of local optima. Many studies have been conducted to solve this problem. One of the solutions is to use meta-heuristic techniques. This paper presents a combination of the Differential evolution and the sailfish optimizer algorithms (DESFO) to tackle the feature selection problem. To assess the effectiveness of the proposed algorithm, a comparison between Differential Evolution, sailfish optimizer, and nine other modern algorithms, including different optimization algorithms, is presented. The evaluation used Random forest and key nearest neighbors as quality measures. The experimental results show that the proposed algorithm is a superior algorithm compared to others. It significantly impacts high classification accuracy, achieving 85.7% with the Random Forest classifier and 100% with the Key Nearest Neighbors classifier across 14 multi-scale benchmarks. According to fitness values, it gained 71% with the Random forest and 85.7% with the Key Nearest Neighbors classifiers., (© 2024. The Author(s).)