1. Suggestive evidence of a multi-cytokine resistin pathway in humans and its role on cardiovascular events in high-risk individuals
- Author
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Concetta De Bonis, Massimiliano Copetti, Claudia Menzaghi, Lorena Ortega Moreno, Vincenzo Trischitta, Lucia Salvemini, Antonella Marucci, Alessandra Antonucci, and Rosa Di Paola
- Subjects
Male ,Interleukin-1beta ,Blood Pressure ,Coronary Artery Disease ,Type 2 diabetes ,030204 cardiovascular system & hematology ,resistin pathway ,Body Mass Index ,Coronary artery disease ,0302 clinical medicine ,Risk Factors ,Medicine ,Resistin ,Prospective Studies ,Middle Aged ,Interleukin-12 ,Female ,Waist Circumference ,hormones, hormone substitutes, and hormone antagonists ,Signal Transduction ,Adult ,cardiovascular risk ,medicine.medical_specialty ,030209 endocrinology & metabolism ,Article ,03 medical and health sciences ,Insulin resistance ,Internal medicine ,Diabetes mellitus ,Humans ,Triglycerides ,Aged ,Interleukin-6 ,Tumor Necrosis Factor-alpha ,business.industry ,Cholesterol, HDL ,Interleukin-8 ,Case-control study ,Cholesterol, LDL ,multidisciplinary ,medicine.disease ,Blood pressure ,Endocrinology ,Diabetes Mellitus, Type 2 ,Gene Expression Regulation ,Case-Control Studies ,Insulin Resistance ,business ,Mace - Abstract
In cells and tissues resistin affects IL-1β, IL-6, IL-8, IL-12 and TNF-α expression, thus suggesting the existence of a multi-cytokine “resistin pathway”. We investigated whether such pathway does exist in humans and, if so, if it is associated with cardiovascular risk factors and with major adverse cardiovascular events (MACE). Serum cytokines were measured in 280 healthy subjects from the Gargano Study 2 (GS2) whose BMI, waist circumference, HOMAIR, triglycerides, HDL-cholesterol, systolic and diastolic blood pressure data were available and in 353 patients with type 2 diabetes and coronary artery disease from the Gargano Heart Study (GHS)-prospective design (follow-up 5.4 ± 2.5 years; 71 MACE). In GS2, cytokines mRNA levels in white blood cells were also measured. In GS2, resistin mRNA was correlated with all cytokines expression (all p
- Published
- 2017
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