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2 results on '"Acín, Enrique"'

1. Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections

Author

Instituto de Salud Carlos III, European Commission, Secretaría Nacional de Ciencia y Tecnología (Panamá), Comas, Iñaki [0000-0001-5504-9408], Chiner-Oms, Álvaro [0000-0002-0463-0101], Abascal, Estefanía, Herranz, Marta, Acosta, Fermín, Agapito, Juan, Cabibbe, Andrea M., Monteserin, Johana, Ruiz Serrano, María Jesús, Gijón, Paloma, Fernández-González, Francisco, Lozano, Nuria, Chiner-Oms, Álvaro, Cáceres, Tatiana, Gómez Pintado, Pilar, Acín, Enrique, Valencia, Eddy, Muñoz, Patricia, Comas, Iñaki, Cirillo, Daniela M., Ritacco, Viviana, Gotuzzo, Eduardo, García de Viedma, Darío, Instituto de Salud Carlos III, European Commission, Secretaría Nacional de Ciencia y Tecnología (Panamá), Comas, Iñaki [0000-0001-5504-9408], Chiner-Oms, Álvaro [0000-0002-0463-0101], Abascal, Estefanía, Herranz, Marta, Acosta, Fermín, Agapito, Juan, Cabibbe, Andrea M., Monteserin, Johana, Ruiz Serrano, María Jesús, Gijón, Paloma, Fernández-González, Francisco, Lozano, Nuria, Chiner-Oms, Álvaro, Cáceres, Tatiana, Gómez Pintado, Pilar, Acín, Enrique, Valencia, Eddy, Muñoz, Patricia, Comas, Iñaki, Cirillo, Daniela M., Ritacco, Viviana, Gotuzzo, Eduardo, and García de Viedma, Darío

Abstract

It is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR-clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002-5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection.

Published
2020

2. Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections.

Author

Abascal E, Herranz M, Acosta F, Agapito J, Cabibbe AM, Monteserin J, Ruiz Serrano MJ, Gijón P, Fernández-González F, Lozano N, Chiner-Oms Á, Cáceres T, Pintado PG, Acín E, Valencia E, Muñoz P, Comas I, Cirillo DM, Ritacco V, Gotuzzo E, and García de Viedma D

Subjects
Antitubercular Agents therapeutic use, Bacterial Typing Techniques, Coinfection, Humans, Mass Screening, Molecular Epidemiology, Mycobacterium tuberculosis isolation & purification, Mycobacterium tuberculosis pathogenicity, Patient Transfer, Peru epidemiology, Prevalence, Prisons, Spain epidemiology, Tuberculosis, Multidrug-Resistant drug therapy, Tuberculosis, Multidrug-Resistant microbiology, Tuberculosis, Multidrug-Resistant transmission, Tuberculosis, Pulmonary drug therapy, Tuberculosis, Pulmonary microbiology, Tuberculosis, Pulmonary transmission, Drug Resistance, Multiple, Bacterial genetics, Mycobacterium tuberculosis genetics, Prisoners, Tuberculosis, Multidrug-Resistant epidemiology, Tuberculosis, Pulmonary epidemiology
Abstract

It is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR-clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002-5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection.

Published
2020
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